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Cmc2 C-x(9)-C motif containing 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 100363376, updated on 13-Apr-2024

Summary

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Symbol
Cmc2provided by RGD
Full Name
C-x(9)-C motif containing 2provided by RGD
Primary source
RGD:2324599
See related
Ensembl:ENSRNOG00000068690 AllianceGenome:RGD:2324599
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to be active in mitochondrion. Orthologous to human CMC2 (C-X9-C motif containing 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Muscle (RPKM 244.5), Heart (RPKM 156.6) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Cmc2 in Genome Data Viewer
Location:
19q12
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 19 NC_086037.1 (61852126..61880768, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 19 NC_051354.1 (44943283..44971930, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 19 NC_005118.4 (49433332..49457641, complement)

Chromosome 19 - NC_086037.1Genomic Context describing neighboring genes Neighboring gene dynein light chain roadblock-type 2 Neighboring gene chromodomain Y-like 2 Neighboring gene uncharacterized LOC134483651 Neighboring gene centromere protein N Neighboring gene ATM interactor

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. The conserved mitochondrial twin Cx9C protein Cmc2 Is a Cmc1 homologue essential for cytochrome c oxidase biogenesis. Horn D, et al. J Biol Chem, 2010 May 14. PMID 20220131, Free PMC Article
  2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Component Evidence Code Pubs
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
COX assembly mitochondrial protein 2 homolog
Names
rCG51296-like

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001402209.1 → NP_001389138.1  COX assembly mitochondrial protein 2 homolog isoform 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000019
    UniProtKB/TrEMBL
    A6IZF8, D4A471

  2. NM_001402210.1 → NP_001389139.1  COX assembly mitochondrial protein 2 homolog isoform 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000019
    UniProtKB/TrEMBL
    A6IZF8, D4A471
    Related
    ENSRNOP00000087382.1, ENSRNOT00000095441.1

  3. NM_001402211.1 → NP_001389140.1  COX assembly mitochondrial protein 2 homolog isoform 2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000019
    UniProtKB/TrEMBL
    A0A8I5ZLA6
    Related
    ENSRNOP00000078459.1, ENSRNOT00000117703.1

  4. NM_001402212.1 → NP_001389141.1  COX assembly mitochondrial protein 2 homolog isoform 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000019
    UniProtKB/TrEMBL
    A6IZF8, D4A471

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086037.1 Reference GRCr8

    Range
    61852126..61880768 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039098177.2 → XP_038954105.1  COX assembly mitochondrial protein 2 homolog isoform X1

    UniProtKB/TrEMBL
    A6IZF8, D4A471
    Conserved Domains (1) summary
    pfam08583
    Location:1 → 70
    Cmc1; Cytochrome c oxidase biogenesis protein Cmc1 like
Nucleotide Protein Strain
Heading Accession and Version

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