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Nktr natural killer cell triggering receptor [ Rattus norvegicus (Norway rat) ]

Gene ID: 100364165, updated on 13-Apr-2024

Summary

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Official Symbol
Nktrprovided by RGD
Official Full Name
natural killer cell triggering receptorprovided by RGD
Primary source
RGD:2321593
See related
Ensembl:ENSRNOG00000049128 AllianceGenome:RGD:2321593
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable cyclosporin A binding activity and peptidyl-prolyl cis-trans isomerase activity. Predicted to be involved in protein folding and protein peptidyl-prolyl isomerization. Predicted to be active in cytoplasm and nucleus. Orthologous to human NKTR (natural killer cell triggering receptor). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Lung (RPKM 215.0), Thymus (RPKM 213.3) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
8q32
Exon count:
19
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (130255541..130298001)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (121380010..121420495)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (130357464..130395425)

Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene SEC22 homolog C, vesicle trafficking protein Neighboring gene SS18 like 2 Neighboring gene zinc finger and BTB domain containing 47 Neighboring gene kelch-like family member 40

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Structural and biochemical characterization of the human cyclophilin family of peptidyl-prolyl isomerases. Davis TL, et al. PLoS Biol, 2010 Jul 27. PMID 20676357, Free PMC Article
  2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables cyclosporin A binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables cyclosporin A binding ISO
Inferred from Sequence Orthology
more info
  
enables peptidyl-prolyl cis-trans isomerase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables peptidyl-prolyl cis-trans isomerase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in protein folding IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein peptidyl-prolyl isomerization IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
NK-tumor recognition protein
Names
natural killer tumor recognition sequence-like
natural killer-tumor recognition sequence
NP_001414339.1
XP_038938667.1
XP_038938669.1
XP_038938673.1
XP_038938674.1
XP_038938678.1
XP_063120781.1
XP_063120782.1
XP_063120783.1
XP_063120784.1
XP_063120785.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001427410.1 → NP_001414339.1  NK-tumor recognition protein

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000008

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086026.1 Reference GRCr8

    Range
    130255541..130298001
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063264715.1 → XP_063120785.1  NK-tumor recognition protein isoform X7

  2. XM_039082750.2 → XP_038938678.1  NK-tumor recognition protein isoform X8

    Conserved Domains (1) summary
    cl00197
    Location:66 → 156
    cyclophilin; cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the immunosuppressive drug ...

  3. XM_063264714.1 → XP_063120784.1  NK-tumor recognition protein isoform X6

  4. XM_039082739.2 → XP_038938667.1  NK-tumor recognition protein isoform X1

    UniProtKB/TrEMBL
    M0R991
    Related
    ENSRNOP00000066054.3
    Conserved Domains (1) summary
    cl00197
    Location:66 → 233
    cyclophilin; cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the immunosuppressive drug ...

  5. XM_039082741.2 → XP_038938669.1  NK-tumor recognition protein isoform X2

    UniProtKB/TrEMBL
    M0R991
    Conserved Domains (1) summary
    cl00197
    Location:66 → 233
    cyclophilin; cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the immunosuppressive drug ...

  6. XM_063264711.1 → XP_063120781.1  NK-tumor recognition protein isoform X4

  7. XM_063264712.1 → XP_063120782.1  NK-tumor recognition protein isoform X4

  8. XM_039082746.2 → XP_038938674.1  NK-tumor recognition protein isoform X3

    UniProtKB/TrEMBL
    M0R991
    Conserved Domains (1) summary
    cl00197
    Location:1 → 62
    cyclophilin; cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the immunosuppressive drug ...

  9. XM_039082745.2 → XP_038938673.1  NK-tumor recognition protein isoform X3

    UniProtKB/TrEMBL
    M0R991
    Conserved Domains (1) summary
    cl00197
    Location:1 → 62
    cyclophilin; cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the immunosuppressive drug ...

  10. XM_063264713.1 → XP_063120783.1  NK-tumor recognition protein isoform X5

RNA

  1. XR_005488595.2 RNA Sequence

  2. XR_005488594.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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