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CYP2C19 cytochrome P450 2C19 [ Callithrix jacchus (white-tufted-ear marmoset) ]

Gene ID: 100389947, updated on 3-Apr-2024

Summary

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Gene symbol
CYP2C19
Gene description
cytochrome P450 2C19
See related
Ensembl:ENSCJAG00000015888
Gene type
protein coding
RefSeq status
MODEL
Organism
Callithrix jacchus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Platyrrhini; Cebidae; Callitrichinae; Callithrix; Callithrix
Orthologs
human all
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Genomic context

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Location:
chromosome: 12
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2023_03 current mCalJa1.2.pat.X (GCF_011100555.1) 12 NC_071453.1 (84191196..84293631)
105 previous assembly Callithrix_jacchus_cj1700_1.1 (GCF_009663435.1) 12 NC_048394.1 (84910521..85013955)

Chromosome 12 - NC_071453.1Genomic Context describing neighboring genes Neighboring gene helicase, lymphoid specific Neighboring gene cytochrome P450 2C18 Neighboring gene tyrosine-protein phosphatase non-receptor type 11-like Neighboring gene vacuolar protein sorting-associated protein 16 homolog Neighboring gene 60S ribosomal protein L7-like 1 Neighboring gene cytochrome P450 2C20 Neighboring gene U6 spliceosomal RNA

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Oxidation of R- and S-omeprazole stereoselectively mediated by liver microsomal cytochrome P450 2C19 enzymes from cynomolgus monkeys and common marmosets. Uehara S, et al. Biochem Pharmacol, 2016 Nov 15. PMID 27641812
  2. Novel Marmoset Cytochrome P450 2C19 in Livers Efficiently Metabolizes Human P450 2C9 and 2C19 Substrates, S-Warfarin, Tolbutamide, Flurbiprofen, and Omeprazole. Uehara S, et al. Drug Metab Dispos, 2015 Oct. PMID 26228688
  3. Retained duplications and deletions of CYP2C genes among primates. Chaney ME, et al. Mol Phylogenet Evol, 2018 Aug. PMID 29631055

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables heme binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables iron ion binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in organic acid metabolic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in xenobiotic metabolic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in intracellular membrane-bounded organelle IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
cytochrome P450 2C19

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_011100555.1-RS_2023_03

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference mCalJa1.2.pat.X

Genomic

  1. NC_071453.1 Reference mCalJa1.2.pat.X

    Range
    84191196..84293631
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_002756462.6 → XP_002756508.3  cytochrome P450 2C19

    UniProtKB/TrEMBL
    F6Q4H7
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

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