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Slc44a1 solute carrier family 44, member 1 [ Mus musculus (house mouse) ]

Gene ID: 100434, updated on 21-Apr-2024

Summary

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Official Symbol
Slc44a1provided by MGI
Official Full Name
solute carrier family 44, member 1provided by MGI
Primary source
MGI:MGI:2140592
See related
Ensembl:ENSMUSG00000028412 AllianceGenome:MGI:2140592
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
CTL1; CHTL1; Cdw92; 2210409B22Rik; 4833416H08Rik
Summary
Enables choline transmembrane transporter activity. Involved in transmembrane transport. Acts upstream of or within choline transport. Is integral component of membrane. Is expressed in several structures, including alimentary system; brain; genitourinary system; hindlimb long bone; and thoracic segment skeleton. Human ortholog(s) of this gene implicated in high grade glioma. Orthologous to human SLC44A1 (solute carrier family 44 member 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in colon adult (RPKM 21.8), bladder adult (RPKM 12.6) and 27 other tissues See more
Orthologs
human all
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Genomic context

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Location:
4 B2; 4 28.66 cM
Exon count:
18
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (53440387..53622478)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (53440387..53622478)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer mm9_chr4:53290912-53291213 Neighboring gene STARR-seq mESC enhancer starr_10223 Neighboring gene macrophage expressed LXRa(NR1H3)-dependent amplifier of Abca1 transcription lncRNA Neighboring gene STARR-seq mESC enhancer starr_10230 Neighboring gene predicted gene 12496 Neighboring gene STARR-positive B cell enhancer mm9_chr4:53397629-53397930 Neighboring gene STARR-seq mESC enhancer starr_10233 Neighboring gene STARR-positive B cell enhancer mm9_chr4:53424836-53425137 Neighboring gene STARR-seq mESC enhancer starr_10238 Neighboring gene predicted gene, 54227 Neighboring gene STARR-seq mESC enhancer starr_10241 Neighboring gene RIKEN cDNA 1700060J05 gene Neighboring gene predicted gene, 54226 Neighboring gene fibronectin type III and SPRY domain containing 1-like Neighboring gene single stranded DNA binding protein 4 pseudogene Neighboring gene fukutin

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Palmitic acid and oleic acid differentially regulate choline transporter-like 1 levels and glycerolipid metabolism in skeletal muscle cells. Schenkel LC, et al. Lipids, 2014 Aug. PMID 24972900
  2. The solute carrier 44A1 is a mitochondrial protein and mediates choline transport. Michel V, et al. FASEB J, 2009 Aug. PMID 19357133
  3. Identification and expression of a mouse muscle-specific CTL1 gene. Yuan Z, et al. Gene, 2004 Oct 27. PMID 15474312
  4. Choline transport for phospholipid synthesis: An emerging role of choline transporter-like protein 1. Hedtke V, et al. Exp Biol Med (Maywood), 2019 May. PMID 30776907, Free PMC Article
  5. Detection of choline transporter-like 1 protein CTL1 in neuroblastoma x glioma cells and in the CNS, and its role in choline uptake. Machová E, et al. J Neurochem, 2009 Aug. PMID 19519661

See all (30) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. SLC44A1 acts as a choline transporter both in the plasma membrane and in the mitochondria. Novel aspects of choline transport regulation in the muscle, nervous system, and cancer are reviewed. Review.
    Title: Choline transport for phospholipid synthesis: An emerging role of choline transporter-like protein 1.
  2. CTL1/SLC44A1 presence at the plasma membrane regulates choline requirements in accordance with the type of fatty acid.
    Title: Palmitic acid and oleic acid differentially regulate choline transporter-like 1 levels and glycerolipid metabolism in skeletal muscle cells.
  3. SLC44A1 mRNA and protein expression were down-regulated during choline deficiency.
    Title: The solute carrier 44A1 is a mitochondrial protein and mediates choline transport.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (3) 
  • Endonuclease-mediated (4) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables antiporter activity IEA
Inferred from Electronic Annotation
more info
  
enables choline transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables choline transmembrane transporter activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables choline transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
  
enables ethanolamine transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
  
enables transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in choline transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in choline transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in choline transport ISO
Inferred from Sequence Orthology
more info
  
involved_in ethanolamine transport ISO
Inferred from Sequence Orthology
more info
  
involved_in transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in transmembrane transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in transmembrane transport ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrial outer membrane ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
choline transporter-like protein 1
Names
CDW92 antigen

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001159633.1 → NP_001153105.1  choline transporter-like protein 1 isoform B

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) has a different exon for its 3'-terminal exon, compared to variant 1, which results in a distinct 3' UTR and a protein (isoform B) with a shorter and distinct C-terminus, compared to isoform A.
    Source sequence(s)
    AK077951, CF532681, CJ054525
    Consensus CDS
    CCDS51178.1
    UniProtKB/TrEMBL
    A2AMH3
    Related
    ENSMUSP00000103273.3, ENSMUST00000107646.9
    Conserved Domains (1) summary
    pfam04515
    Location:292 → 497
    Choline_transpo; Plasma-membrane choline transporter

  2. NM_001374697.1 → NP_001361626.1  choline transporter-like protein 1 isoform C

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) encodes the longest isoform (C).
    Source sequence(s)
    AL805900, AL807745
    Consensus CDS
    CCDS89743.1
    UniProtKB/TrEMBL
    A2AMH5
    Related
    ENSMUSP00000103278.3, ENSMUST00000107651.9
    Conserved Domains (1) summary
    pfam04515
    Location:293 → 603
    Choline_transpo; Plasma-membrane choline transporter

  3. NM_133891.3 → NP_598652.3  choline transporter-like protein 1 isoform A

    See identical proteins and their annotated locations for NP_598652.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes isoform A.
    Source sequence(s)
    AK077951, BB271503, BC113167, BQ031280
    Consensus CDS
    CCDS18189.1
    UniProtKB/Swiss-Prot
    Q14DK0, Q6X893, Q6X894, Q8R0Y4, Q91Z29
    Related
    ENSMUSP00000099975.4, ENSMUST00000102911.10
    Conserved Domains (1) summary
    pfam04515
    Location:292 → 603
    Choline_transpo; Plasma-membrane choline transporter

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    53440387..53622478
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006537531.4 → XP_006537594.1  choline transporter-like protein 1 isoform X1

    UniProtKB/TrEMBL
    A2AMH4
    Related
    ENSMUSP00000103274.2, ENSMUST00000107647.8
    Conserved Domains (1) summary
    pfam04515
    Location:293 → 603
    Choline_transpo; Plasma-membrane choline transporter

  2. XM_030253067.1 → XP_030108927.1  choline transporter-like protein 1 isoform X3

    UniProtKB/TrEMBL
    A2AMH8
    Related
    ENSMUSP00000103272.2, ENSMUST00000107645.2
    Conserved Domains (1) summary
    pfam04515
    Location:68 → 378
    Choline_transpo; Plasma-membrane choline transporter

  3. XM_006537533.4 → XP_006537596.1  choline transporter-like protein 1 isoform X2

    Conserved Domains (1) summary
    pfam04515
    Location:253 → 563
    Choline_transpo; Plasma-membrane choline transporter
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6X893.3 GenPept UniProtKB/Swiss-Prot:Q6X893

Gene LinkOut

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