U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

MTRNR2L6 MT-RNR2 like 6 (pseudogene) [ Homo sapiens (human) ]

Gene ID: 100463482, updated on 8-Mar-2024

Summary

Go to the top of the page Help
Official Symbol
MTRNR2L6provided by HGNC
Official Full Name
MT-RNR2 like 6 (pseudogene)provided by HGNC
Primary source
HGNC:HGNC:37163
See related
AllianceGenome:HGNC:37163
Gene type
pseudo
RefSeq status
INFERRED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HN6
Summary
Predicted to enable receptor antagonist activity. Predicted to be involved in negative regulation of execution phase of apoptosis. Predicted to be located in cytoplasm and extracellular region. [provided by Alliance of Genome Resources, Apr 2022]
Annotation information
Note: It is unclear if this is a transcribed protein-coding gene, or if it is a nuclear pseudogene of the mitochondrial MT-RNR2 gene. [16 Mar 2015]
Orthologs
all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
7q34
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (142667017..142667685)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (144022710..144023378)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (142374849..142375517)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene T cell receptor beta locus Neighboring gene Sharpr-MPRA regulatory region 11750 Neighboring gene MPRA-validated peak6801 silencer Neighboring gene T cell receptor beta variable 23-1 (non-functional) Neighboring gene T cell receptor beta variable 24-1 Neighboring gene T cell receptor beta variable 25-1 Neighboring gene T cell receptor beta variable A (pseudogene)

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Immunolocalization of humanin in human sperm and testis. Moretti E, et al. Fertil Steril, 2010 Dec. PMID 20542501
  2. Humanin: a novel central regulator of peripheral insulin action. Muzumdar RH, et al. PLoS One, 2009 Jul 22. PMID 19623253, Free PMC Article
  3. The human mitochondrial genome may code for more than 13 proteins. Capt C, et al. Mitochondrial DNA A DNA Mapp Seq Anal, 2016 Sep. PMID 25630734
  4. Humanin: a harbinger of mitochondrial-derived peptides? Lee C, et al. Trends Endocrinol Metab, 2013 May. PMID 23402768, Free PMC Article
  5. Humanin peptide suppresses apoptosis by interfering with Bax activation. Guo B, et al. Nature, 2003 May 22. PMID 12732850

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

Go to the top of the page Help

Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

Go to the top of the page Help

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

General gene information

Go to the top of the page Help

Homology

Other Names

  • MT-RNR2 pseudogene 6
  • humanin-like 6
  • humanin-like protein 6

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables receptor antagonist activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in negative regulation of execution phase of apoptosis IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_077210.1 

    Range
    101..769
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

    Range
    142667017..142667685
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p14 ALT_REF_LOCI_1

Genomic

  1. NT_187562.1 Reference GRCh38.p14 ALT_REF_LOCI_1

    Range
    669570..670238
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060931.1 Alternate T2T-CHM13v2.0

    Range
    144022710..144023378
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001190487.2: Suppressed sequence

    Description
    NM_001190487.2: This RefSeq was removed because it is now thought that this gene does not encode a protein.
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P0CJ73.1 GenPept UniProtKB/Swiss-Prot:P0CJ73

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous