Lao1 L-amino acid oxidase 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Lao1provided by MGI
Official Full Name: L-amino acid oxidase 1provided by MGI
Primary source: MGI:MGI:2140628
See related: Ensembl:ENSMUSG00000024903 AllianceGenome:MGI:2140628
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary: Enables L-amino-acid oxidase activity. Acts upstream of or within cellular amino acid catabolic process. Located in extracellular region. [provided by Alliance of Genome Resources, Apr 2022]
Expression: Low expression observed in reference dataset See more
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Genomic context

Location:: 4 D2.1; 4 55.24 cM

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	4	NC_000070.7 (118819164..118826107)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	4	NC_000070.6 (118961967..118968910)

Chromosome 4 - NC_000070.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

L-amino acid oxidase 1 in sperm is associated with reproductive performance in male mice and bulls.
Title: L-amino acid oxidase 1 in sperm is associated with reproductive performance in male mice and bulls.
LAO1 KO mice exhibited impaired fear learning and memory owing to low hippocampal acetylcholine levels.
Title: Hippocampal metabolism of amino acids by L-amino acid oxidase is involved in fear learning and memory.
this is the first demonstration showing that LAO expression is induced in cell culture, and stimulation of lactogenic hormone and change of histone modification are promising signals to show highly expression of LAO in lactating mammary glands.
Title: Lactogenic hormone stimulation and epigenetic control of L-amino acid oxidase expression in lactating mammary glands.
LAO-knockout mice were healthy and had normal mammary gland development; however, the antibacterial activity normally observed in milk from wild-type mice was absent from the milk of knockout mice.
Title: L-amino acid oxidase plays a crucial role in host defense in the mammary glands.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (1) 1 citation
Endonuclease-mediated (2)

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables L-amino-acid oxidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables L-amino-acid oxidase activity	IDA Inferred from Direct Assay more info	PubMed
enables polyamine oxidase activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in amino acid catabolic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within amino acid catabolic process	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in extracellular region	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: L-amino acid oxidase 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_133892.4 → NP_598653.3 L-amino acid oxidase 1 precursor

See identical proteins and their annotated locations for NP_598653.3

Status: VALIDATED

Source sequence(s)

AK052781, AL606922

Consensus CDS

CCDS18568.1

UniProtKB/TrEMBL

B1ARV3, Q8VEN4

Related

ENSMUSP00000062834.5, ENSMUST00000058651.5

Conserved Domains (2) summary

pfam01593
Location:67 → 508

Amino_oxidase; Flavin containing amine oxidoreductase

pfam13450
Location:62 → 129

NAD_binding_8; NAD(P)-binding Rossmann-like domain