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H2-Ea histocompatibility 2, class II antigen E alpha [ Mus musculus (house mouse) ]

Gene ID: 100504404, updated on 16-Oct-2021

Summary

Official Symbol
H2-Eaprovided by MGI
Official Full Name
histocompatibility 2, class II antigen E alphaprovided by MGI
Primary source
MGI:MGI:95900
See related
Ensembl:ENSMUSG00000036322
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Ia3; Ia-3; H-2Ea; AI323765; H2-Ea-ps; I-Ealpha; E-alpha-f; MHC-H2-Ea
Summary
This locus belongs to the class II major histocompatibility complex (MHC) family of genes, which encode immune response (Ia) antigens that function in the T-cell-dependent immune response. This family member has multiple haplotypes, some of which result in the production of an E-alpha subunit that combines with an E-beta subunit to form a functional E complex at the cell surface. Other haplotypes, including that of the reference genome allele, contain mutations and they thus represent polymorphic pseudogenes that do not produce functional products. These mutations include frameshifting indels, nonsense mutations, and deletions of larger regions. The reference genome haplotype contains a deletion at the 5' end of the gene, including the core promoter region and the transcription start site, and therefore no transcripts result from this haplotype. [provided by RefSeq, Aug 2011]
Expression
Low expression observed in reference dataset See more
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Genomic context

See H2-Ea in Genome Data Viewer
Location:
17 B1; 17 17.98 cM
Exon count:
4
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (34560926..34563619, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (34341952..34344645, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 17 NC_000083.5 (34478902..34484492, complement)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene histocompatibility 2, class II antigen E beta Neighboring gene histocompatibility 2, class II antigen E beta2 Neighboring gene butyrophilin-like 2 Neighboring gene butyrophilin-like 1

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC117888

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables MHC class II protein complex binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
part_of MHC class II protein complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
histocompatibility 2, class II antigen E alpha
Names
H-2 class II histocompatibility antigen, E-D alpha chain
H-2 class II histocompatibility antigen, E-K alpha chain
H-2 class II histocompatibility antigen, E-U alpha chain
H2-IE-alpha
I-E alpha MHC class II
MHC class II H2-E alpha chain
MHC class II alpha chain
MHC class II antigen E alpha
MHC class II antigen IEk-alpha
MHC class II protein
histocompatibility 2, class II antigen E alpha, pseudogene

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_010381.3NP_034511.3  histocompatibility 2, class II antigen E alpha precursor

    Status: VALIDATED

    Source sequence(s)
    BC106107
    Conserved Domains (2) summary
    cd05767
    Location:111204
    IgC_MHC_II_alpha; Class II major histocompatibility complex (MHC) alpha chain immunoglobulin domain
    pfam00993
    Location:29107
    MHC_II_alpha; Class II histocompatibility antigen, alpha domain

RNA

  1. NR_164196.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    CR974457
    Related
    ENSMUST00000235482.2

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    34560926..34563619 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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