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LINC00707 long intergenic non-protein coding RNA 707 [ Homo sapiens (human) ]

Gene ID: 100507127, updated on 8-Apr-2024

Summary

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Official Symbol
LINC00707provided by HGNC
Official Full Name
long intergenic non-protein coding RNA 707provided by HGNC
Primary source
HGNC:HGNC:44691
See related
Ensembl:ENSG00000238266 AllianceGenome:HGNC:44691
Gene type
ncRNA
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Expression
Biased expression in gall bladder (RPKM 1.5), placenta (RPKM 0.4) and 3 other tissues See more
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Genomic context

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Location:
10p14
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (6779598..6842906)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (6779906..6842664)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (6821560..6884868)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene MED14-independent group 3 enhancer GRCh37_chr10:6778731-6779930 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:6779977-6780522 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:6780523-6781066 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2969 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:6835894-6836851 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:6836852-6837808 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:6838766-6839721 Neighboring gene H3K27ac hESC enhancer GRCh37_chr10:6843478-6844062 Neighboring gene long intergenic non-protein coding RNA 706 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr10:6844063-6844646 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr10:6844647-6845230 Neighboring gene lncRNA in non-homologous end joining pathway 1 Neighboring gene uncharacterized LOC105376387 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr10:6874691-6875192 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr10:6875193-6875692 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:6918964-6919464 Neighboring gene NANOG hESC enhancer GRCh37_chr10:6952013-6952514 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2970 Neighboring gene nonconserved acetylation island sequence 45 enhancer Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr10:6975635-6976834 Neighboring gene NANOG hESC enhancer GRCh37_chr10:6995095-6995596 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr10:7014138-7015337 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_16768 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_16971 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2110 Neighboring gene ReSE screen-validated silencer GRCh37_chr10:7117931-7118110 Neighboring gene NANOG hESC enhancer GRCh37_chr10:7124870-7125371 Neighboring gene long intergenic non-protein coding RNA 2665 Neighboring gene Sharpr-MPRA regulatory region 5095 Neighboring gene H3K27ac hESC enhancer GRCh37_chr10:7212385-7212885 Neighboring gene Scm like with four mbt domains 2 Neighboring gene small nucleolar RNA, C/D box 129

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. LINC00707 Promotes Cell Proliferation in Cervical Cancer via the miR-374c-5p/SDC4 Axis. Fang F, et al. Biomed Res Int, 2022. PMID 35937409, Free PMC Article
  2. LINC00707 knockdown inhibits IL-1β-induced apoptosis and extracellular matrix degradation of osteoarthritis chondrocytes by the miR-330-5p/FSHR axis. Qian M, et al. Immunopharmacol Immunotoxicol, 2022 Oct. PMID 35536095
  3. Long Noncoding RNA LINC00707 Accelerates Tumorigenesis and Progression of Bladder Cancer via Targeting miR-145/CDCA3 Regulatory Loop. Gao T, et al. Urol Int, 2021. PMID 34192702
  4. Long intergenic noncoding RNA 00707 promotes colorectal cancer cell proliferation and metastasis by sponging miR-206. Zhu H, et al. Onco Targets Ther, 2019. PMID 31213848, Free PMC Article
  5. LINC00707 promotes cell proliferation and invasion of colorectal cancer via miR-206/FMNL2 axis. Shao HJ, et al. Eur Rev Med Pharmacol Sci, 2019 May. PMID 31115001

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Non-adherent culture method affects the proliferation and apoptosis of mesenchymal stem cells through inhibiting LINC00707 to promote RNF6-mediated QKI ubiquitination.
    Title: Non-adherent culture method affects the proliferation and apoptosis of mesenchymal stem cells through inhibiting LINC00707 to promote RNF6-mediated QKI ubiquitination.
  2. LINC00707 promotes multidrug resistance of ovarian cancer cells by targeting the miR-382-5p/LRRK2 axis.
    Title: LINC00707 promotes multidrug resistance of ovarian cancer cells by targeting the miR-382-5p/LRRK2 axis.
  3. The long non-coding RNA LINC00707 interacts with Smad proteins to regulate TGFbeta signaling and cancer cell invasion.
    Title: The long non-coding RNA LINC00707 interacts with Smad proteins to regulate TGFβ signaling and cancer cell invasion.
  4. LINC00707 knockdown inhibits IL-1beta-induced apoptosis and extracellular matrix degradation of osteoarthritis chondrocytes by the miR-330-5p/FSHR axis.
    Title: LINC00707 knockdown inhibits IL-1β-induced apoptosis and extracellular matrix degradation of osteoarthritis chondrocytes by the miR-330-5p/FSHR axis.
  5. LncRNA LINC00707 serves as a sponge of miR-382-5p to alleviate lipopolysaccharide (LPS)-induced WI-38 cell injury through upregulating NKAP in infantile pneumonia.
    Title: LncRNA LINC00707 serves as a sponge of miR-382-5p to alleviate lipopolysaccharide (LPS)-induced WI-38 cell injury through upregulating NKAP in infantile pneumonia.
  6. Long Noncoding RNA LINC00707 Accelerates Tumorigenesis and Progression of Bladder Cancer via Targeting miR-145/CDCA3 Regulatory Loop.
    Title: Long Noncoding RNA LINC00707 Accelerates Tumorigenesis and Progression of Bladder Cancer via Targeting miR-145/CDCA3 Regulatory Loop.
  7. LINC00707 Regulates miR-382-5p/VEGFA Pathway to Enhance Cervical Cancer Progression.
    Title: LINC00707 Regulates miR-382-5p/VEGFA Pathway to Enhance Cervical Cancer Progression.
  8. The Long Intergenic Noncoding RNA 00707 Sponges MicroRNA-613 (miR-613) to Promote Proliferation and Invasion of Gliomas.
    Title: The Long Intergenic Noncoding RNA 00707 Sponges MicroRNA-613 (miR-613) to Promote Proliferation and Invasion of Gliomas.
  9. Knockdown of lncRNA LINC00707 alleviates LPS-induced injury in MRC-5 cells by acting as a ceRNA of miR-223-5p.
    Title: Knockdown of lncRNA LINC00707 alleviates LPS-induced injury in MRC-5 cells by acting as a ceRNA of miR-223-5p.
  10. Downregulation of LINC00707 promotes osteogenic differentiation of human bone marrowderived mesenchymal stem cells by regulating DKK1 via targeting miR103a3p.
    Title: Downregulation of LINC00707 promotes osteogenic differentiation of human bone marrow‑derived mesenchymal stem cells by regulating DKK1 via targeting miR‑103a‑3p.
Submit: New GeneRIF Correction See all GeneRIFs (16)

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

General gene information

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Markers

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

RNA

  1. NR_038291.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AK094154, AL392086, BM990174
    Related
    ENST00000436383.2

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

    Range
    6779598..6842906
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060934.1 Alternate T2T-CHM13v2.0

    Range
    6779906..6842664
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

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Other Literature Sources
Molecular Biology Databases