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MINCR MYC-induced long non-coding RNA [ Homo sapiens (human) ]

Gene ID: 100507316, updated on 10-Oct-2023

Summary

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Official Symbol
MINCRprovided by HGNC
Official Full Name
MYC-induced long non-coding RNAprovided by HGNC
Primary source
HGNC:HGNC:51653
See related
Ensembl:ENSG00000253716 AllianceGenome:HGNC:51653
Gene type
ncRNA
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
LINC01604
Expression
Ubiquitous expression in fat (RPKM 4.1), thyroid (RPKM 2.9) and 25 other tissues See more
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Genomic context

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Location:
8q24.3
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 8 NC_000008.11 (143280155..143281700, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 8 NC_060932.1 (144427547..144429093, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (144362325..144363870, complement)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19611 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19612 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:144332854-144333354 Neighboring gene ZFP41 zinc finger protein Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19613 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19614 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:144350631-144351453 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28067 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:144353055-144353555 Neighboring gene GLI family zinc finger 4 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:144357207-144357850 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:144357851-144358494 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:144361711-144362353 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28068 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:144373076-144373651 Neighboring gene zinc finger protein 696 Neighboring gene uncharacterized LOC124902037

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Long non-coding RNA MINCR regulates the growth and metastasis of human osteosarcoma cells via Wnt/β-catenin signaling pathway. Bai S, et al. Acta Biochim Pol, 2022 Jun 29. PMID 35767742
  2. Long Non-coding RNA MINCR Regulates miR-876-5p/GSPT1 Axis to Aggravate Glioma Progression. Li Z, et al. Neurochem Res, 2020 Jul. PMID 32333234
  3. Roles of MYC-targeting long non-coding RNA MINCR in cell cycle regulation and apoptosis in non-small cell lung Cancer. Chen S, et al. Respir Res, 2019 Sep 3. PMID 31481083, Free PMC Article
  4. LncRNA MINCR activates Wnt/β-catenin signals to promote cell proliferation and migration in oral squamous cell carcinoma. Lyu Q, et al. Pathol Res Pract, 2019 May. PMID 30777615
  5. Overexpression of long non-coding RNA MINCR contributes to progressive clinicopathological features and poor prognosis of human hepatocellular carcinoma. Jin XL, et al. Eur Rev Med Pharmacol Sci, 2018 Dec. PMID 30556858

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. A review on the role of MYC-induced long non-coding RNA in human disorders.
    Title: A review on the role of MYC-induced long non-coding RNA in human disorders.
  2. Long non-coding RNA MINCR regulates the growth and metastasis of human osteosarcoma cells via Wnt/beta-catenin signaling pathway.
    Title: Long non-coding RNA MINCR regulates the growth and metastasis of human osteosarcoma cells via Wnt/β-catenin signaling pathway.
  3. Long Non-coding RNA MINCR Regulates miR-876-5p/GSPT1 Axis to Aggravate Glioma Progression.
    Title: Long Non-coding RNA MINCR Regulates miR-876-5p/GSPT1 Axis to Aggravate Glioma Progression.
  4. Long non-coding RNA MINCR aggravates colon cancer via regulating miR-708-5p-mediated Wnt/beta-catenin pathway.
    Title: Long non-coding RNA MINCR aggravates colon cancer via regulating miR-708-5p-mediated Wnt/β-catenin pathway.
  5. LncRNA MINCR promotes the development of liver cancer by regulating microRNA-107/beta-catenin.
    Title: LncRNA MINCR promotes the development of liver cancer by regulating microRNA-107/β-catenin.
  6. Expression and Significance of LncRNA-MINCR and CDK2 mRNA in Primary Hepatocellular Carcinoma
    Title: Expression and Significance of LncRNA-MINCR and CDK2 mRNA in Primary Hepatocellular Carcinoma.
  7. MINCR exerted inhibitory effects on the cell cycle arrest and apoptosis of non-small cell lung cancer cells.
    Title: Roles of MYC-targeting long non-coding RNA MINCR in cell cycle regulation and apoptosis in non-small cell lung Cancer.
  8. MINCR overexpression in hepatocellular carcinoma tissues correlates with clinicopathological disease progression and poor prognosis.
    Title: Overexpression of long non-coding RNA MINCR contributes to progressive clinicopathological features and poor prognosis of human hepatocellular carcinoma.
  9. Dysfunction of MINCR, miR-126 and SLC7A5 predicted poor prognosis of patients with non-small cell lung cancer.
    Title: Up-regulation of long noncoding RNA MINCR promotes non-small cell of lung cancer growth by negatively regulating miR-126/SLC7A5 axis.
  10. our findings revealed that MINCR may be an oncogene in oral squamous cell carcinoma via modulation of Wnt/beta-catenin pathway.
    Title: LncRNA MINCR activates Wnt/β-catenin signals to promote cell proliferation and migration in oral squamous cell carcinoma.
Submit: New GeneRIF Correction See all GeneRIFs (13)

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

General gene information

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Other Names

  • MYC-induced long noncoding RNA
  • TCONS_00015189
  • long intergenic non-protein coding RNA 1604

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

RNA

  1. NR_120682.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript.
    Source sequence(s)
    AA992445, AC138696, AW975318, HY339014, HY368981
    Related
    ENST00000517411.4

  2. NR_120683.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 3' exon structure, resulting in a shorter transcript, compared to variant 1.
    Source sequence(s)
    AA284855, AJ346444, BM987389, HY368981

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p14 Primary Assembly

    Range
    143280155..143281700 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060932.1 Alternate T2T-CHM13v2.0

    Range
    144427547..144429093 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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Molecular Biology Databases