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CENPS-CORT CENPS-CORT readthrough [ Homo sapiens (human) ]

Gene ID: 100526739, updated on 23-Nov-2021

Summary

Official Symbol
CENPS-CORTprovided by HGNC
Official Full Name
CENPS-CORT readthroughprovided by HGNC
Primary source
HGNC:HGNC:38843
See related
Ensembl:ENSG00000251503
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MHF1; CENPS; APITD1; CENP-S; FAAP16; APITD1-CORT
Summary
This locus represents naturally occurring read-through transcription between the neighboring APITD1 (apoptosis-inducing, TAF9-like domain 1) and CORT (cortistatin) genes. Alternative splicing results in multiple transcript variants, two of which encode fusion proteins that share sequence identity with the products of each individual gene. [provided by RefSeq, Aug 2011]
Expression
Broad expression in testis (RPKM 17.2), kidney (RPKM 10.2) and 23 other tissues See more
Orthologs
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Genomic context

See CENPS-CORT in Genome Data Viewer
Location:
1p36.22
Exon count:
7
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (10430433..10452153)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (10490490..10512210)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene phosphogluconate dehydrogenase Neighboring gene Sharpr-MPRA regulatory region 15261 Neighboring gene centromere protein S Neighboring gene cortistatin Neighboring gene DNA fragmentation factor subunit alpha Neighboring gene Sharpr-MPRA regulatory region 5895 Neighboring gene peroxisomal biogenesis factor 14

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Readthrough CENPS-CORT

Included genes: CORT, CENPS

Homology

Clone Names

  • KIAA0591

General protein information

Preferred Names
APITD1-CORT protein
Names
APITD1-CORT readthrough
Apoptosis-inducing TAF9-like domain-containing protein 1
Centromere protein S
FANCM-associated histone fold protein 1
FANCM-interacting histone fold protein 1
Fanconi anemia-associated polypeptide of 16 kDa

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001243768.2NP_001230697.1  APITD1-CORT protein isoform 3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks two exons and includes an alternate exon in the 5' UTR and coding region, and uses an alternate start codon, compared to variant 1. The encoded isoform (3) is shorter and has a distinct N-terminus, compared to isoform 1.
    Source sequence(s)
    AL139424, AL354956, CF128105
    Consensus CDS
    CCDS72699.1
    UniProtKB/TrEMBL
    A0A087WT10
    Related
    ENSP00000473401.2, ENST00000602296.6
    Conserved Domains (2) summary
    pfam03002
    Location:125142
    Somatostatin; Somatostatin/Cortistatin family
    pfam15630
    Location:3771
    CENP-S; Kinetochore component CENP-S
  2. NM_001270517.2NP_001257446.1  APITD1-CORT protein isoform 4

    See identical proteins and their annotated locations for NP_001257446.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) has an additional exon in the center region, compared to variant 1. The resulting isoform (4) is shorter and has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AF521016, AL354956, HY054077
    UniProtKB/Swiss-Prot
    Q8N2Z9
    Related
    ENSP00000473509.2, ENST00000602787.6
    Conserved Domains (1) summary
    pfam15630
    Location:1792
    CENP-S; CENP-S protein
  3. NM_198544.4NP_940946.1  APITD1-CORT protein isoform 1

    See identical proteins and their annotated locations for NP_940946.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1), which shares sequence identity with the products of both the APITD1 and CORT genes.
    Source sequence(s)
    AF521016, AL354956
    Consensus CDS
    CCDS114.1
    UniProtKB/Swiss-Prot
    Q8N2Z9
    Related
    ENSP00000383692.2, ENST00000400900.6
    Conserved Domains (2) summary
    pfam03002
    Location:146163
    Somatostatin; Somatostatin/Cortistatin family
    pfam15630
    Location:1792
    CENP-S; Kinetochore component CENP-S
  4. NM_199006.3NP_950171.2  APITD1-CORT protein isoform 2

    See identical proteins and their annotated locations for NP_950171.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an exon in the 3' coding region, which results in a frameshift and an early stop codon, compared to variant 1. The encoded isoform (2) has a distinct and shorter C-terminus, and lacks sequence identity with the product of the CORT gene, compared to isoform 1.
    Source sequence(s)
    AF516753, AF521016, AL354956
    Consensus CDS
    CCDS53266.1
    UniProtKB/Swiss-Prot
    Q8N2Z9
    Related
    ENSP00000433615.1, ENST00000470413.6
    Conserved Domains (1) summary
    pfam15630
    Location:1769
    CENP-S; Kinetochore component CENP-S

RNA

  1. NR_037187.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) contains alternate exon structure in the 5' region, compared to variant 1. This variant is represented as non-coding because it lacks a significant portion of the 5' coding region, including the start codon, as found in variant 1, and it also contains multiple upstream ORFs that are predicted to inhibit the translation of the longest in-frame ORF.
    Source sequence(s)
    AA858169, AL139424, AL354956

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    10430433..10452153
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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