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slc16a1a solute carrier family 16 member 1a [ Danio rerio (zebrafish) ]

Gene ID: 100534752, updated on 11-Apr-2024

Summary

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Official Symbol
slc16a1aprovided by ZNC
Official Full Name
solute carrier family 16 member 1aprovided by ZNC
Primary source
ZFIN:ZDB-GENE-110408-16
See related
Ensembl:ENSDARG00000016963 AllianceGenome:ZFIN:ZDB-GENE-110408-16
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
mct1b; slc16a1b; si:ch211-105j21.7
Summary
Predicted to enable monocarboxylic acid transmembrane transporter activity. Predicted to be involved in monocarboxylic acid transport. Predicted to act upstream of or within transmembrane transport. Predicted to be located in plasma membrane. Predicted to be integral component of plasma membrane. Human ortholog(s) of this gene implicated in familial hyperinsulinemic hypoglycemia 7. Orthologous to human SLC16A1 (solute carrier family 16 member 1). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
all
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Genomic context

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See slc16a1a in Genome Data Viewer
Location:
chromosome: 6
Exon count:
7
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 6 NC_007117.7 (48977306..49049037)
105 previous assembly GRCz10 (GCF_000002035.5) 6 NC_007117.6 (48978651..49050403)

Chromosome 6 - NC_007117.7Genomic Context describing neighboring genes Neighboring gene TAFA chemokine like family member 3a Neighboring gene uncharacterized LOC108190503 Neighboring gene si:ch211-105j21.9 Neighboring gene solute carrier family 5 member 8, like Neighboring gene synaptonemal complex protein 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. scRNA Transcription Profile of Adult Zebrafish Podocytes Using a Novel Reporter Strain. Brown C, et al. Cell Physiol Biochem, 2021 May 5. PMID 33945241
  2. O2-filled swimbladder employs monocarboxylate transporters for the generation of O2 by lactate-induced root effect hemoglobin. Umezawa T, et al. PLoS One, 2012. PMID 22496829, Free PMC Article
  3. Evolutionary and Expression Analysis of MOV10 and MOV10L1 Reveals Their Origin, Duplication and Divergence. Yang S, et al. Int J Mol Sci, 2022 Jul 7. PMID 35886872, Free PMC Article
  4. Contrasted innate responses to two viruses in zebrafish: insights into the ancestral repertoire of vertebrate IFN-stimulated genes. Briolat V, et al. J Immunol, 2014 May 1. PMID 24683187
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables lactate:proton symporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables monocarboxylic acid transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
  
enables transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within monocarboxylic acid transport IEA
Inferred from Electronic Annotation
more info
  
involved_in plasma membrane lactate transport IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in basolateral plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
monocarboxylate transporter 1a; solute carrier family 16 (monocarboxylate transporter), member 1a
Names
monocarboxylate transporter 1b
solute carrier family 16 (monocarboxylic acid transporters), member 1b

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001256640.1 → NP_001243569.1  monocarboxylate transporter 1a

    See identical proteins and their annotated locations for NP_001243569.1

    Status: PROVISIONAL

    Source sequence(s)
    AB610606
    UniProtKB/TrEMBL
    A0A8M1P4I6, H1ABV8
    Related
    ENSDARP00000144244.1, ENSDART00000175254.2
    Conserved Domains (2) summary
    cd06174
    Location:20 → 415
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
    TIGR00892
    Location:6 → 446
    2A0113; monocarboxylate transporter 1

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007117.7 Reference GRCz11 Primary Assembly

    Range
    48977306..49049037
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005172095.4 → XP_005172152.1  solute carrier family 16 (monocarboxylate transporter), member 1a isoform X1

    See identical proteins and their annotated locations for XP_005172152.1

    UniProtKB/TrEMBL
    A0A8M2BJH4, E7F7B3
    Related
    ENSDARP00000123786.1, ENSDART00000150023.3
    Conserved Domains (2) summary
    cd06174
    Location:20 → 415
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
    TIGR00892
    Location:6 → 444
    2A0113; monocarboxylate transporter 1

  2. XM_005172096.4 → XP_005172153.1  solute carrier family 16 (monocarboxylate transporter), member 1a isoform X1

    See identical proteins and their annotated locations for XP_005172153.1

    UniProtKB/TrEMBL
    A0A8M2BJH4, E7F7B3
    Related
    ENSDARP00000124803.1, ENSDART00000149394.2
    Conserved Domains (2) summary
    cd06174
    Location:20 → 415
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
    TIGR00892
    Location:6 → 444
    2A0113; monocarboxylate transporter 1

Reference GRCz11 ALT_DRER_TU_1

Genomic

  1. NW_018394668.1 Reference GRCz11 ALT_DRER_TU_1

    Range
    129967..149386
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

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