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BRCA1 BRCA1 DNA repair associated [ Nomascus leucogenys (northern white-cheeked gibbon) ]

Gene ID: 100580360, updated on 27-Nov-2020

Summary

Gene symbol
BRCA1
Gene description
BRCA1 DNA repair associated
See related
Ensembl:ENSNLEG00000011944
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Nomascus leucogenys
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hylobatidae; Nomascus
Orthologs
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Genomic context

See BRCA1 in Genome Data Viewer
Location:
chromosome: Un
Exon count:
22
Annotation release Status Assembly Chr Location
103 current Asia_NLE_v1 (GCF_006542625.1) Unplaced Scaffold NW_022095770.1 (121755..206152)
102 previous assembly Nleu_3.0 (GCF_000146795.2) Unplaced Scaffold NW_003501569.1 (1973911..2103417, complement)

NW_022095770.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC115833608 Neighboring gene uncharacterized LOC115833609 Neighboring gene Rho family GTPase 2 Neighboring gene vesicle amine transport 1

Genomic regions, transcripts, and products

General gene information

Markers

Homology

General protein information

Preferred Names
breast cancer type 1 susceptibility protein
Names
breast cancer type 1 susceptibility protein homolog
NP_001295597.1
XP_030663935.1
XP_030663936.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001308668.1NP_001295597.1  breast cancer type 1 susceptibility protein

    See identical proteins and their annotated locations for NP_001295597.1

    Status: PROVISIONAL

    Source sequence(s)
    KM017627
    UniProtKB/TrEMBL
    A0A075VSA7
    Conserved Domains (4) summary
    smart00292
    Location:17581842
    BRCT; breast cancer carboxy-terminal domain
    cd00027
    Location:16501724
    BRCT; Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo ...
    cd00162
    Location:2368
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
    pfam12820
    Location:345507
    BRCT_assoc; Serine-rich domain associated with BRCT

RefSeqs of Annotated Genomes: Nomascus leucogenys Annotation Release 103 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Asia_NLE_v1 Primary Assembly

Genomic

  1. NW_022095770.1 Reference Asia_NLE_v1 Primary Assembly

    Range
    121755..206152
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030808075.1XP_030663935.1  breast cancer type 1 susceptibility protein isoform X1

    Conserved Domains (4) summary
    cd16498
    Location:1865
    RING-HC_BRCA1; RING finger, HC subclass, found in breast cancer type 1 susceptibility protein (BRCA1) and similar proteins
    cd17721
    Location:17571854
    BRCT_BRCA1_rpt2; second (C-terminal) BRCT domain of breast cancer type 1 susceptibility protein (BRCA1) and similar proteins
    cd17735
    Location:16491745
    BRCT_BRCA1_rpt1; first BRCT domain of breast cancer type 1 susceptibility protein (BRCA1) and similar proteins
    pfam12820
    Location:345507
    BRCT_assoc; Serine-rich domain associated with BRCT
  2. XM_030808076.1XP_030663936.1  breast cancer type 1 susceptibility protein isoform X2

    Conserved Domains (4) summary
    cd16498
    Location:1865
    RING-HC_BRCA1; RING finger, HC subclass, found in breast cancer type 1 susceptibility protein (BRCA1) and similar proteins
    cd17721
    Location:17571854
    BRCT_BRCA1_rpt2; second (C-terminal) BRCT domain of breast cancer type 1 susceptibility protein (BRCA1) and similar proteins
    cd17735
    Location:16491745
    BRCT_BRCA1_rpt1; first BRCT domain of breast cancer type 1 susceptibility protein (BRCA1) and similar proteins
    pfam12820
    Location:344506
    BRCT_assoc; Serine-rich domain associated with BRCT