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MMP2 matrix metallopeptidase 2 [ Nomascus leucogenys (northern white-cheeked gibbon) ]

Gene ID: 100597186, updated on 8-Mar-2024

Summary

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Gene symbol
MMP2
Gene description
matrix metallopeptidase 2
See related
EnsemblRapid:ENSNLEG00000001210
Gene type
protein coding
RefSeq status
MODEL
Organism
Nomascus leucogenys
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hylobatidae; Nomascus
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 2
Exon count:
18
Annotation release Status Assembly Chr Location
103 current Asia_NLE_v1 (GCF_006542625.1) 2 NC_044382.1 (64758912..64874877, complement)
102 previous assembly Nleu_3.0 (GCF_000146795.2) 2 NC_019817.1 (67995836..68023167, complement)

Chromosome 2 - NC_044382.1Genomic Context describing neighboring genes Neighboring gene solute carrier family 6 member 2 Neighboring gene lysophosphatidylcholine acyltransferase 2 Neighboring gene calpain small subunit 2 Neighboring gene uncharacterized LOC115830954 Neighboring gene iroquois homeobox 6 Neighboring gene iroquois homeobox 5

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables metalloendopeptidase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in collagen catabolic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in extracellular matrix organization IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in response to hypoxia IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in tissue remodeling IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in extracellular matrix IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
72 kDa type IV collagenase
Names
matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Nomascus leucogenys Annotation Release 103 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Asia_NLE_v1 Primary Assembly

Genomic

  1. NC_044382.1 Reference Asia_NLE_v1 Primary Assembly

    Range
    64758912..64874877 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030796923.1 → XP_030652783.1  72 kDa type IV collagenase isoform X2

    UniProtKB/TrEMBL
    G1QKN0
    Conserved Domains (4) summary
    smart00059
    Location:316 → 364
    FN2; Fibronectin type 2 domain
    cd00094
    Location:440 → 634
    HX; Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of ...
    pfam00413
    Location:92 → 420
    Peptidase_M10; Matrixin
    pfam01471
    Location:44 → 71
    PG_binding_1; Putative peptidoglycan binding domain

  2. XM_003263057.4 → XP_003263105.2  72 kDa type IV collagenase isoform X1

    UniProtKB/TrEMBL
    G1QKN0
    Related
    ENSNLEP00000001477.3, ENSNLET00000001560.3
    Conserved Domains (4) summary
    smart00059
    Location:342 → 390
    FN2; Fibronectin type 2 domain
    cd00094
    Location:466 → 660
    HX; Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of ...
    pfam00413
    Location:118 → 446
    Peptidase_M10; Matrixin
    pfam01471
    Location:70 → 97
    PG_binding_1; Putative peptidoglycan binding domain

  3. XM_030796941.1 → XP_030652801.1  72 kDa type IV collagenase isoform X4

    UniProtKB/TrEMBL
    G1QKN0
    Conserved Domains (4) summary
    smart00059
    Location:266 → 314
    FN2; Fibronectin type 2 domain
    cd00094
    Location:390 → 584
    HX; Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of ...
    pfam00413
    Location:42 → 370
    Peptidase_M10; Matrixin
    pfam01471
    Location:1 → 21
    PG_binding_1; Putative peptidoglycan binding domain

  4. XM_030796933.1 → XP_030652793.1  72 kDa type IV collagenase isoform X4

    UniProtKB/TrEMBL
    G1QKN0
    Conserved Domains (4) summary
    smart00059
    Location:266 → 314
    FN2; Fibronectin type 2 domain
    cd00094
    Location:390 → 584
    HX; Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of ...
    pfam00413
    Location:42 → 370
    Peptidase_M10; Matrixin
    pfam01471
    Location:1 → 21
    PG_binding_1; Putative peptidoglycan binding domain

  5. XM_030796927.1 → XP_030652787.1  72 kDa type IV collagenase isoform X3

    UniProtKB/TrEMBL
    G1QKN0
    Related
    ENSNLEP00000060051.1, ENSNLET00000071435.1
    Conserved Domains (4) summary
    smart00059
    Location:292 → 340
    FN2; Fibronectin type 2 domain
    cd00094
    Location:416 → 610
    HX; Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of ...
    pfam00413
    Location:68 → 396
    Peptidase_M10; Matrixin
    pfam01471
    Location:20 → 47
    PG_binding_1; Putative peptidoglycan binding domain
Nucleotide Protein
Heading Accession and Version

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