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MIR4708 microRNA 4708 [ Homo sapiens (human) ]

Gene ID: 100616176, updated on 10-Oct-2023

Summary

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Official Symbol
MIR4708provided by HGNC
Official Full Name
microRNA 4708provided by HGNC
Primary source
HGNC:HGNC:41824
See related
Ensembl:ENSG00000266740 miRBase:MI0017341; AllianceGenome:HGNC:41824
Gene type
ncRNA
RefSeq status
PROVISIONAL
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
mir-4708
Summary
microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
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Genomic context

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See MIR4708 in Genome Data Viewer
Location:
14q23.3
Exon count:
1
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 14 NC_000014.9 (65335117..65335183, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 14 NC_060938.1 (59539952..59540018, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (65801835..65801901, complement)

Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr14:65748624-65749192 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8552 Neighboring gene ribosomal protein L36a pseudogene 2 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8553 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8554 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5849 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8555 Neighboring gene polypyrimidine tract binding protein 1 pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8556 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8557 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8558 Neighboring gene H3K27ac hESC enhancer GRCh37_chr14:65795645-65796416 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:65797276-65797886 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8560 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8559 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr14:65822645-65823844 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8562 Neighboring gene fucosyltransferase 8 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8563 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5850 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5851 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr14:65880189-65880753 Neighboring gene MPRA-validated peak2170 silencer Neighboring gene MPRA-validated peak2171 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8564 Neighboring gene FUT8 antisense RNA 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8565 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_35208 Neighboring gene ribosomal protein L21 pseudogene 8

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Identification of new microRNAs in paired normal and tumor breast tissue suggests a dual role for the ERBB2/Her2 gene. Persson H, et al. Cancer Res, 2011 Jan 1. PMID 21199797
  2. miRBase: integrating microRNA annotation and deep-sequencing data. Kozomara A, et al. Nucleic Acids Res, 2011 Jan. PMID 21037258, Free PMC Article
  3. miRBase: microRNA sequences, targets and gene nomenclature. Griffiths-Jones S, et al. Nucleic Acids Res, 2006 Jan 1. PMID 16381832, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

General gene information

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Other Names

  • hsa-mir-4708

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

RNA

  1. NR_039857.1 RNA Sequence

    Status: PROVISIONAL

    Source sequence(s)
    AL359236
    Related
    ENST00000584635.1

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000014.9 Reference GRCh38.p14 Primary Assembly

    Range
    65335117..65335183 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060938.1 Alternate T2T-CHM13v2.0

    Range
    59539952..59540018 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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