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MIR4540 microRNA 4540 [ Homo sapiens (human) ]

Gene ID: 100616278, updated on 10-Oct-2023

Summary

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Official Symbol
MIR4540provided by HGNC
Official Full Name
microRNA 4540provided by HGNC
Primary source
HGNC:HGNC:41670
See related
Ensembl:ENSG00000264922 miRBase:MI0016911; AllianceGenome:HGNC:41670
Gene type
ncRNA
RefSeq status
PROVISIONAL
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
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Genomic context

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Location:
9p13.2
Exon count:
1
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 9 NC_000009.12 (36864254..36864308, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 9 NC_060933.1 (36887839..36887893, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (36864251..36864305, complement)

Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19896 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:36584821-36585797 Neighboring gene ReSE screen-validated silencer GRCh37_chr9:36596422-36596589 Neighboring gene maternal embryonic leucine zipper kinase Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28355 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:36725931-36726432 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr9:36738402-36739601 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19897 Neighboring gene ReSE screen-validated silencer GRCh37_chr9:36756569-36756775 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:36764310-36764828 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:36764829-36765347 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28356 Neighboring gene uncharacterized LOC105376030 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19898 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:36820286-36820786 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:36848015-36848854 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr9:36851359-36852558 Neighboring gene microRNA 4475 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28357 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:36867937-36868628 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28358 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:36879416-36880112 Neighboring gene paired box 5 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:36900581-36901081 Neighboring gene MTA1-activated intronic PAX5 enhancer Neighboring gene microRNA 4476 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28359 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28360 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28361 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28362 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:36947656-36948180 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:36961379-36962370 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:36962371-36963361 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:36980425-36980924 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:36986501-36987456 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28363 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28364 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28365 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28366 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:36996149-36996649 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:36997151-36997666 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:36997667-36998181 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28368 Neighboring gene uncharacterized LOC105376032 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28369

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Deep sequencing of the small RNA transcriptome of normal and malignant human B cells identifies hundreds of novel microRNAs. Jima DD, et al. Blood, 2010 Dec 2. PMID 20733160, Free PMC Article
  2. miRBase: microRNA sequences, targets and gene nomenclature. Griffiths-Jones S, et al. Nucleic Acids Res, 2006 Jan 1. PMID 16381832, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

General gene information

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Other Names

  • hsa-mir-4540

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

RNA

  1. NR_039766.1 RNA Sequence

    Status: PROVISIONAL

    Source sequence(s)
    AL450267
    Related
    ENST00000583532.1

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000009.12 Reference GRCh38.p14 Primary Assembly

    Range
    36864254..36864308 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060933.1 Alternate T2T-CHM13v2.0

    Range
    36887839..36887893 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

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