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MME membrane metalloendopeptidase [ Loxodonta africana (African savanna elephant) ]

Gene ID: 100676161, updated on 11-Apr-2024

Summary

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Gene symbol
MME
Gene description
membrane metalloendopeptidase
See related
EnsemblRapid:ENSLAFG00000015397
Gene type
protein coding
RefSeq status
MODEL
Organism
Loxodonta africana
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Afrotheria; Proboscidea; Elephantidae; Loxodonta
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 23
Exon count:
22
Annotation release Status Assembly Chr Location
RS_2024_04 current mLoxAfr1.hap2 (GCF_030014295.1) 23 NC_087364.1 (72259106..72351649)
102 previous assembly Loxafr3.0 (GCF_000001905.1) Unplaced Scaffold NW_003573461.1 (5172699..5268997, complement)

Chromosome 23 - NC_087364.1Genomic Context describing neighboring genes Neighboring gene DEAH-box helicase 36 Neighboring gene G protein-coupled receptor 149 Neighboring gene large ribosomal subunit protein eL21-like Neighboring gene small transmembrane regulator of ion transport 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables metalloendopeptidase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in amyloid-beta clearance IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in protein processing IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
neprilysin

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_030014295.1-RS_2024_04

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference mLoxAfr1.hap2

Genomic

  1. NC_087364.1 Reference mLoxAfr1.hap2

    Range
    72259106..72351649
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_003416139.4 → XP_003416187.1  neprilysin

    UniProtKB/TrEMBL
    G3TF27
    Related
    ENSLAFP00000012903.3, ENSLAFT00000015399.4
    Conserved Domains (2) summary
    cd08662
    Location:77 → 748
    M13; Peptidase family M13 includes neprilysin, endothelin-converting enzyme I
    COG3590
    Location:72 → 750
    PepO; Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]
Nucleotide Protein
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