Dhfr dihydrofolate reductase [Cricetulus griseus (Chinese hamster)] - Gene

Summary

Gene symbol: Dhfr
Gene description: dihydrofolate reductase
Locus tag: I79_015631
See related: Ensembl:ENSCGRG00015034133
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Cricetulus griseus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Cricetidae; Cricetinae; Cricetulus
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 2

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
104	current	CriGri_1.0 (GCF_000223135.1)	Unplaced Scaffold	NW_003614442.1 (464809..488594, complement)
104	current	CriGri-PICRH-1.0 (GCF_003668045.3)	2	NC_048595.1 (311116057..311139836)

NW_003614442.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Point mutations and indel mutations at the endogenous loci of the dihydrofolate reductase can be successfully repaired.
Title: Correction of point mutations at the endogenous locus of the dihydrofolate reductase gene using repair-PolyPurine Reverse Hoogsteen hairpins in mammalian cells.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables NADP binding	IEA Inferred from Electronic Annotation more info	PubMed
enables dihydrofolate reductase activity	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in dihydrofolate metabolic process	IEA Inferred from Electronic Annotation more info	PubMed
involved_in folic acid metabolic process	IEA Inferred from Electronic Annotation more info	PubMed
involved_in glycine biosynthetic process	IEA Inferred from Electronic Annotation more info	PubMed
involved_in tetrahydrofolate biosynthetic process	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in mitochondrion	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: dihydrofolate reductase

NP_001230945.1

EC 1.5.1.3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001244016.1 → NP_001230945.1 dihydrofolate reductase

See identical proteins and their annotated locations for NP_001230945.1

Status: PROVISIONAL

Source sequence(s)

K01164

UniProtKB/TrEMBL

A0A9J7CH09, Q2MH30

Related

ENSCGRP00015060322.1, ENSCGRT00015064161.1

Conserved Domains (1) summary

cd00209
Location:5 → 184

DHFR; Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5, ...