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Scn8a sodium voltage-gated channel alpha subunit 8 [ Cricetulus griseus (Chinese hamster) ]

Gene ID: 100764200, updated on 8-Mar-2024

Summary

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Gene symbol
Scn8a
Gene description
sodium voltage-gated channel alpha subunit 8
Locus tag
I79_021185
See related
Ensembl:ENSCGRG00015028596
Gene type
protein coding
RefSeq status
MODEL
Organism
Cricetulus griseus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Cricetidae; Cricetinae; Cricetulus
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 2
Exon count:
28
Annotation release Status Assembly Chr Location
104 current CriGri_1.0 (GCF_000223135.1) Unplaced Scaffold NW_003615454.1 (16230..117624)
104 current CriGri-PICRH-1.0 (GCF_003668045.3) 2 NC_048595.1 (397324384..397487361)

NW_003615454.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC118237807 Neighboring gene ankyrin repeat domain 33 Neighboring gene activin A receptor like type 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Unraveling the Chinese hamster ovary cell line transcriptome by next-generation sequencing. Becker J, et al. J Biotechnol, 2011 Dec 10. PMID 21945585

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables protein binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables voltage-gated sodium channel activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in membrane depolarization during action potential IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in neuronal action potential IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in sodium ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in axon IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 
part_of voltage-gated sodium channel complex IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
sodium channel protein type 8 subunit alpha
Names
Sodium channel protein type 8 subunit alpha
sodium channel, voltage gated, type VIII, alpha subunit
sodium channel, voltage-gated, type VIII, alpha

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Cricetulus griseus Annotation Release 104 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference CriGri_1.0 Primary Assembly

Genomic

  1. NW_003615454.1 Reference CriGri_1.0 Primary Assembly

    Range
    16230..117624
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_035436845.1 → XP_035292736.1  sodium channel protein type 8 subunit alpha isoform X1

    UniProtKB/TrEMBL
    A0A8C2LVH6
    Conserved Domains (6) summary
    smart00015
    Location:1861 → 1882
    IQ; Calmodulin-binding motif
    cd13433
    Location:1432 → 1484
    Na_channel_gate; Inactivation gate of the voltage-gated sodium channel alpha subunits
    pfam00520
    Location:760 → 973
    Ion_trans; Ion transport protein
    pfam06512
    Location:999 → 1200
    Na_trans_assoc; Sodium ion transport-associated
    pfam11933
    Location:504 → 710
    Na_trans_cytopl; Cytoplasmic domain of voltage-gated Na+ ion channel
    pfam16905
    Location:1755 → 1802
    GPHH; Voltage-dependent L-type calcium channel, IQ-associated

  2. XM_027384491.2 → XP_027240292.1  sodium channel protein type 8 subunit alpha isoform X10

    UniProtKB/TrEMBL
    A0A8C2LR27

  3. XM_027384493.2 → XP_027240294.1  sodium channel protein type 8 subunit alpha isoform X3

    UniProtKB/TrEMBL
    A0A8C2LVH6

  4. XM_027384489.2 → XP_027240290.1  sodium channel protein type 8 subunit alpha isoform X8

    UniProtKB/TrEMBL
    A0A8C2LR27

  5. XM_027384492.2 → XP_027240293.1  sodium channel protein type 8 subunit alpha isoform X2

    UniProtKB/TrEMBL
    A0A8C2LVH6

  6. XM_027384490.2 → XP_027240291.1  sodium channel protein type 8 subunit alpha isoform X9

    UniProtKB/TrEMBL
    A0A8C2LR27

  7. XM_035436847.1 → XP_035292738.1  sodium channel protein type 8 subunit alpha isoform X4

    UniProtKB/TrEMBL
    A0A8C2LVH6
    Conserved Domains (6) summary
    smart00015
    Location:1851 → 1872
    IQ; Calmodulin-binding motif
    cd13433
    Location:1422 → 1474
    Na_channel_gate; Inactivation gate of the voltage-gated sodium channel alpha subunits
    pfam00520
    Location:750 → 963
    Ion_trans; Ion transport protein
    pfam06512
    Location:989 → 1190
    Na_trans_assoc; Sodium ion transport-associated
    pfam11933
    Location:504 → 700
    Na_trans_cytopl; Cytoplasmic domain of voltage-gated Na+ ion channel
    pfam16905
    Location:1745 → 1792
    GPHH; Voltage-dependent L-type calcium channel, IQ-associated

  8. XM_035436848.1 → XP_035292739.1  sodium channel protein type 8 subunit alpha isoform X5

    UniProtKB/TrEMBL
    A0A8C2LVH6
    Conserved Domains (6) summary
    smart00015
    Location:1735 → 1756
    IQ; Calmodulin-binding motif
    cd13433
    Location:1306 → 1358
    Na_channel_gate; Inactivation gate of the voltage-gated sodium channel alpha subunits
    pfam00520
    Location:1363 → 1617
    Ion_trans; Ion transport protein
    pfam06512
    Location:873 → 1074
    Na_trans_assoc; Sodium ion transport-associated
    pfam11933
    Location:378 → 584
    Na_trans_cytopl; Cytoplasmic domain of voltage-gated Na+ ion channel
    pfam16905
    Location:1629 → 1676
    GPHH; Voltage-dependent L-type calcium channel, IQ-associated

  9. XM_035436850.1 → XP_035292741.1  sodium channel protein type 8 subunit alpha isoform X6

    UniProtKB/TrEMBL
    A0A8C2LVH6
    Conserved Domains (6) summary
    smart00015
    Location:1699 → 1720
    IQ; Calmodulin-binding motif
    cd13433
    Location:1270 → 1322
    Na_channel_gate; Inactivation gate of the voltage-gated sodium channel alpha subunits
    pfam00520
    Location:598 → 811
    Ion_trans; Ion transport protein
    pfam06512
    Location:837 → 1038
    Na_trans_assoc; Sodium ion transport-associated
    pfam11933
    Location:342 → 548
    Na_trans_cytopl; Cytoplasmic domain of voltage-gated Na+ ion channel
    pfam16905
    Location:1593 → 1640
    GPHH; Voltage-dependent L-type calcium channel, IQ-associated

  10. XM_035436849.1 → XP_035292740.1  sodium channel protein type 8 subunit alpha isoform X6

    UniProtKB/TrEMBL
    A0A8C2LVH6
    Conserved Domains (6) summary
    smart00015
    Location:1699 → 1720
    IQ; Calmodulin-binding motif
    cd13433
    Location:1270 → 1322
    Na_channel_gate; Inactivation gate of the voltage-gated sodium channel alpha subunits
    pfam00520
    Location:598 → 811
    Ion_trans; Ion transport protein
    pfam06512
    Location:837 → 1038
    Na_trans_assoc; Sodium ion transport-associated
    pfam11933
    Location:342 → 548
    Na_trans_cytopl; Cytoplasmic domain of voltage-gated Na+ ion channel
    pfam16905
    Location:1593 → 1640
    GPHH; Voltage-dependent L-type calcium channel, IQ-associated

  11. XM_035436853.1 → XP_035292744.1  sodium channel protein type 8 subunit alpha isoform X7

    UniProtKB/TrEMBL
    A0A8C2LVH6
    Conserved Domains (6) summary
    smart00015
    Location:1607 → 1628
    IQ; Calmodulin-binding motif
    cd13433
    Location:1178 → 1230
    Na_channel_gate; Inactivation gate of the voltage-gated sodium channel alpha subunits
    pfam00520
    Location:506 → 719
    Ion_trans; Ion transport protein
    pfam06512
    Location:745 → 946
    Na_trans_assoc; Sodium ion transport-associated
    pfam11933
    Location:250 → 456
    Na_trans_cytopl; Cytoplasmic domain of voltage-gated Na+ ion channel
    pfam16905
    Location:1501 → 1548
    GPHH; Voltage-dependent L-type calcium channel, IQ-associated

  12. XM_035436851.1 → XP_035292742.1  sodium channel protein type 8 subunit alpha isoform X7

    UniProtKB/TrEMBL
    A0A8C2LVH6
    Conserved Domains (6) summary
    smart00015
    Location:1607 → 1628
    IQ; Calmodulin-binding motif
    cd13433
    Location:1178 → 1230
    Na_channel_gate; Inactivation gate of the voltage-gated sodium channel alpha subunits
    pfam00520
    Location:506 → 719
    Ion_trans; Ion transport protein
    pfam06512
    Location:745 → 946
    Na_trans_assoc; Sodium ion transport-associated
    pfam11933
    Location:250 → 456
    Na_trans_cytopl; Cytoplasmic domain of voltage-gated Na+ ion channel
    pfam16905
    Location:1501 → 1548
    GPHH; Voltage-dependent L-type calcium channel, IQ-associated

  13. XM_035436852.1 → XP_035292743.1  sodium channel protein type 8 subunit alpha isoform X7

    UniProtKB/TrEMBL
    A0A8C2LVH6
    Conserved Domains (6) summary
    smart00015
    Location:1607 → 1628
    IQ; Calmodulin-binding motif
    cd13433
    Location:1178 → 1230
    Na_channel_gate; Inactivation gate of the voltage-gated sodium channel alpha subunits
    pfam00520
    Location:506 → 719
    Ion_trans; Ion transport protein
    pfam06512
    Location:745 → 946
    Na_trans_assoc; Sodium ion transport-associated
    pfam11933
    Location:250 → 456
    Na_trans_cytopl; Cytoplasmic domain of voltage-gated Na+ ion channel
    pfam16905
    Location:1501 → 1548
    GPHH; Voltage-dependent L-type calcium channel, IQ-associated

Alternate CriGri-PICRH-1.0

Genomic

  1. NC_048595.1 Alternate CriGri-PICRH-1.0

    Range
    397324384..397487361
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_035440884.1 → XP_035296775.1  sodium channel protein type 8 subunit alpha isoform X3

    UniProtKB/TrEMBL
    A0A8C2LVH6, A0A9J7K5I9
    Conserved Domains (6) summary
    smart00015
    Location:1851 → 1872
    IQ; Calmodulin-binding motif
    cd13433
    Location:1422 → 1474
    Na_channel_gate; Inactivation gate of the voltage-gated sodium channel alpha subunits
    pfam00520
    Location:1479 → 1733
    Ion_trans; Ion transport protein
    pfam06512
    Location:989 → 1190
    Na_trans_assoc; Sodium ion transport-associated
    pfam11933
    Location:504 → 700
    Na_trans_cytopl; Cytoplasmic domain of voltage-gated Na+ ion channel
    pfam16905
    Location:1745 → 1792
    GPHH; Voltage-dependent L-type calcium channel, IQ-associated

  2. XM_027396611.2 → XP_027252412.1  sodium channel protein type 8 subunit alpha isoform X8

    UniProtKB/TrEMBL
    A0A8C2LR27, A0A9J7FBL3
    Related
    ENSCGRP00015038268.2, ENSCGRT00015046595.2

  3. XM_035440883.1 → XP_035296774.1  sodium channel protein type 8 subunit alpha isoform X2

    UniProtKB/TrEMBL
    A0A8C2LVH6, A0A9J7JVE1
    Conserved Domains (6) summary
    smart00015
    Location:1861 → 1882
    IQ; Calmodulin-binding motif
    cd13433
    Location:1432 → 1484
    Na_channel_gate; Inactivation gate of the voltage-gated sodium channel alpha subunits
    pfam00520
    Location:1489 → 1743
    Ion_trans; Ion transport protein
    pfam06512
    Location:999 → 1200
    Na_trans_assoc; Sodium ion transport-associated
    pfam11933
    Location:504 → 710
    Na_trans_cytopl; Cytoplasmic domain of voltage-gated Na+ ion channel
    pfam16905
    Location:1755 → 1802
    GPHH; Voltage-dependent L-type calcium channel, IQ-associated

  4. XM_035440885.1 → XP_035296776.1  sodium channel protein type 8 subunit alpha isoform X4

    UniProtKB/TrEMBL
    A0A8C2LVH6, A0A9J7K435
    Conserved Domains (6) summary
    smart00015
    Location:1851 → 1872
    IQ; Calmodulin-binding motif
    cd13433
    Location:1422 → 1474
    Na_channel_gate; Inactivation gate of the voltage-gated sodium channel alpha subunits
    pfam00520
    Location:1479 → 1733
    Ion_trans; Ion transport protein
    pfam06512
    Location:989 → 1190
    Na_trans_assoc; Sodium ion transport-associated
    pfam11933
    Location:504 → 700
    Na_trans_cytopl; Cytoplasmic domain of voltage-gated Na+ ion channel
    pfam16905
    Location:1745 → 1792
    GPHH; Voltage-dependent L-type calcium channel, IQ-associated

  5. XM_035440886.1 → XP_035296777.1  sodium channel protein type 8 subunit alpha isoform X5

    UniProtKB/TrEMBL
    A0A8C2LVH6, A0A9J7GRF7
    Conserved Domains (6) summary
    smart00015
    Location:1735 → 1756
    IQ; Calmodulin-binding motif
    cd13433
    Location:1306 → 1358
    Na_channel_gate; Inactivation gate of the voltage-gated sodium channel alpha subunits
    pfam00520
    Location:1363 → 1617
    Ion_trans; Ion transport protein
    pfam06512
    Location:873 → 1074
    Na_trans_assoc; Sodium ion transport-associated
    pfam11933
    Location:378 → 584
    Na_trans_cytopl; Cytoplasmic domain of voltage-gated Na+ ion channel
    pfam16905
    Location:1629 → 1676
    GPHH; Voltage-dependent L-type calcium channel, IQ-associated

  6. XM_035440888.1 → XP_035296779.1  sodium channel protein type 8 subunit alpha isoform X6

    UniProtKB/TrEMBL
    A0A8C2LVH6, A0A9J7GPW5
    Related
    ENSCGRP00015047319.1, ENSCGRT00015067197.1
    Conserved Domains (6) summary
    smart00015
    Location:1699 → 1720
    IQ; Calmodulin-binding motif
    cd13433
    Location:1270 → 1322
    Na_channel_gate; Inactivation gate of the voltage-gated sodium channel alpha subunits
    pfam00520
    Location:1327 → 1581
    Ion_trans; Ion transport protein
    pfam06512
    Location:837 → 1038
    Na_trans_assoc; Sodium ion transport-associated
    pfam11933
    Location:342 → 548
    Na_trans_cytopl; Cytoplasmic domain of voltage-gated Na+ ion channel
    pfam16905
    Location:1593 → 1640
    GPHH; Voltage-dependent L-type calcium channel, IQ-associated

  7. XM_035440887.1 → XP_035296778.1  sodium channel protein type 8 subunit alpha isoform X6

    UniProtKB/TrEMBL
    A0A8C2LVH6, A0A9J7GPW5
    Related
    ENSCGRP00015038267.2, ENSCGRT00015046594.2
    Conserved Domains (6) summary
    smart00015
    Location:1699 → 1720
    IQ; Calmodulin-binding motif
    cd13433
    Location:1270 → 1322
    Na_channel_gate; Inactivation gate of the voltage-gated sodium channel alpha subunits
    pfam00520
    Location:1327 → 1581
    Ion_trans; Ion transport protein
    pfam06512
    Location:837 → 1038
    Na_trans_assoc; Sodium ion transport-associated
    pfam11933
    Location:342 → 548
    Na_trans_cytopl; Cytoplasmic domain of voltage-gated Na+ ion channel
    pfam16905
    Location:1593 → 1640
    GPHH; Voltage-dependent L-type calcium channel, IQ-associated

  8. XM_035440891.1 → XP_035296782.1  sodium channel protein type 8 subunit alpha isoform X7

    UniProtKB/TrEMBL
    A0A8C2LVH6, A0A9J7GTT7
    Conserved Domains (6) summary
    smart00015
    Location:1607 → 1628
    IQ; Calmodulin-binding motif
    cd13433
    Location:1178 → 1230
    Na_channel_gate; Inactivation gate of the voltage-gated sodium channel alpha subunits
    pfam00520
    Location:1235 → 1489
    Ion_trans; Ion transport protein
    pfam06512
    Location:745 → 946
    Na_trans_assoc; Sodium ion transport-associated
    pfam11933
    Location:250 → 456
    Na_trans_cytopl; Cytoplasmic domain of voltage-gated Na+ ion channel
    pfam16905
    Location:1501 → 1548
    GPHH; Voltage-dependent L-type calcium channel, IQ-associated

  9. XM_035440889.1 → XP_035296780.1  sodium channel protein type 8 subunit alpha isoform X7

    UniProtKB/TrEMBL
    A0A8C2LVH6, A0A9J7GTT7
    Conserved Domains (6) summary
    smart00015
    Location:1607 → 1628
    IQ; Calmodulin-binding motif
    cd13433
    Location:1178 → 1230
    Na_channel_gate; Inactivation gate of the voltage-gated sodium channel alpha subunits
    pfam00520
    Location:1235 → 1489
    Ion_trans; Ion transport protein
    pfam06512
    Location:745 → 946
    Na_trans_assoc; Sodium ion transport-associated
    pfam11933
    Location:250 → 456
    Na_trans_cytopl; Cytoplasmic domain of voltage-gated Na+ ion channel
    pfam16905
    Location:1501 → 1548
    GPHH; Voltage-dependent L-type calcium channel, IQ-associated

  10. XM_035440890.1 → XP_035296781.1  sodium channel protein type 8 subunit alpha isoform X7

    UniProtKB/TrEMBL
    A0A8C2LVH6, A0A9J7GTT7
    Conserved Domains (6) summary
    smart00015
    Location:1607 → 1628
    IQ; Calmodulin-binding motif
    cd13433
    Location:1178 → 1230
    Na_channel_gate; Inactivation gate of the voltage-gated sodium channel alpha subunits
    pfam00520
    Location:1235 → 1489
    Ion_trans; Ion transport protein
    pfam06512
    Location:745 → 946
    Na_trans_assoc; Sodium ion transport-associated
    pfam11933
    Location:250 → 456
    Na_trans_cytopl; Cytoplasmic domain of voltage-gated Na+ ion channel
    pfam16905
    Location:1501 → 1548
    GPHH; Voltage-dependent L-type calcium channel, IQ-associated
Nucleotide Protein Strain
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