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CYP3A7-CYP3A51P CYP3A7-CYP3A51P readthrough [ Homo sapiens (human) ]

Gene ID: 100861540, updated on 5-Jan-2022

Summary

Official Symbol
CYP3A7-CYP3A51Pprovided by HGNC
Official Full Name
CYP3A7-CYP3A51P readthroughprovided by HGNC
Primary source
HGNC:HGNC:51504
See related
Ensembl:ENSG00000282301
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CYP3A7; CYPIIIA7; CYP3A7.1L; CYP3A7-3AP1; CYP3A7-CYP3AP1
Summary
This locus represents readthrough transcription between the neighboring CYP3A7 (cytochrome P450, family 3, subfamily A, polypeptide 7) and CYP3A51P (cytochrome P450, family 3, subfamily A, polypeptide 51, pseudogene) genes, which are members of the CYP3A gene cluster on chromosome 7. The downstream pseudogene is not known to be independently transcribed. The readthrough transcript includes CYP3A7 exons 1-13 and exons 2 and 13 of the pseudogene. It encodes a CYP3A isoform with a novel C-terminus. This isoform is only expressed in alleles containing a T nucleotide at the -6 position of a splice acceptor in the pseudogene, which enables correct splicing of the upstream CYP3A7 exons to the pseudogene exons. It should be noted that the reference genome sequence represents the CYP3A7_39256 T->A allele, and thus this haplotype is unlikely to produce the readthrough transcript. [provided by RefSeq, Jan 2015]
Expression
Biased expression in liver (RPKM 21.3), gall bladder (RPKM 4.5) and 4 other tissues See more
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Genomic context

See CYP3A7-CYP3A51P in Genome Data Viewer
Location:
7q22.1
Exon count:
15
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 7 NC_000007.14 (99684677..99735196, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (99282300..99332819, complement)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene zinc finger and SCAN domain containing 25 Neighboring gene ADP ribosylation factor 6 pseudogene Neighboring gene cytochrome P450 family 3 subfamily A member 5 Neighboring gene CYP3A5 promoter Neighboring gene cytochrome P450 family 3 subfamily A member 51, pseudogene Neighboring gene cytochrome P450 family 3 subfamily A member 7 Neighboring gene CYP3A7 5' regulatory region Neighboring gene cytochrome P450, family 3, subfamily A, polypeptide 5 pseudogene 2 Neighboring gene enhancer in intron 10 of CYP3A4 Neighboring gene cytochrome P450 family 3 subfamily A member 4

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Pathways from PubChem

General gene information

Markers

Homology

General protein information

Preferred Names
CYP3A7-CYP3A51P protein
Names
CYP3A7-CYP3AP1 readthrough
Cytochrome P450 3A7
Cytochrome P450-HFLA
NP_001243426.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001256497.3NP_001243426.2  CYP3A7-CYP3A51P protein

    See identical proteins and their annotated locations for NP_001243426.2

    Status: VALIDATED

    Source sequence(s)
    AC005020, AC069294, AF315325
    Consensus CDS
    CCDS75639.1
    UniProtKB/Swiss-Prot
    P24462
    Related
    ENSP00000480571.1, ENST00000611620.4
    Conserved Domains (1) summary
    pfam00067
    Location:39492
    p450; Cytochrome P450

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p13 Primary Assembly

    Range
    99684677..99735196 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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