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Entpd4b ectonucleoside triphosphate diphosphohydrolase 4B [ Mus musculus (house mouse) ]

Gene ID: 100862375, updated on 8-Feb-2024

Summary

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Official Symbol
Entpd4bprovided by MGI
Official Full Name
ectonucleoside triphosphate diphosphohydrolase 4Bprovided by MGI
Primary source
MGI:MGI:5435040
See related
Ensembl:ENSMUSG00000022066 AllianceGenome:MGI:5435040
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Gm21685
Summary
Predicted to enable pyrophosphatase activity. Predicted to be involved in nucleobase-containing small molecule metabolic process. Predicted to be located in Golgi membrane and autophagosome membrane. Predicted to be integral component of Golgi membrane and integral component of autophagosome membrane. Orthologous to human ENTPD4 (ectonucleoside triphosphate diphosphohydrolase 4). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in adrenal adult (RPKM 86.2), kidney adult (RPKM 56.5) and 26 other tissues See more
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Genomic context

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Location:
14 D2; 14
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (69792850..69822389)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (69555401..69584940)

Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_37056 Neighboring gene predicted gene 27179 Neighboring gene predicted gene, 41194 Neighboring gene predicted gene 27174 Neighboring gene STARR-positive B cell enhancer mm9_chr14:69942500-69942801 Neighboring gene STARR-positive B cell enhancer mm9_chr14:69943894-69944195 Neighboring gene STARR-positive B cell enhancer mm9_chr14:69955006-69955307 Neighboring gene predicted gene, 53865 Neighboring gene predicted gene 27177 Neighboring gene STARR-positive B cell enhancer mm9_chr14:69994605-69994905 Neighboring gene lysyl oxidase-like 2 Neighboring gene STARR-positive B cell enhancer mm9_chr14:70029225-70029526 Neighboring gene microRNA 6950 Neighboring gene STARR-positive B cell enhancer ABC_E4117 Neighboring gene R3H domain and coiled-coil containing 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables CDP phosphatase activity ISO
Inferred from Sequence Orthology
more info
  
enables CTPase activity ISO
Inferred from Sequence Orthology
more info
  
enables GDP phosphatase activity ISO
Inferred from Sequence Orthology
more info
  
enables UDP phosphatase activity ISO
Inferred from Sequence Orthology
more info
  
enables nucleoside diphosphate phosphatase activity ISO
Inferred from Sequence Orthology
more info
  
enables ribonucleoside triphosphate phosphatase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in CTP metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in GDP catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in UDP catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in nucleobase-containing small molecule catabolic process ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in Golgi membrane ISO
Inferred from Sequence Orthology
more info
  
located_in autophagosome membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
ectonucleoside triphosphate diphosphohydrolase 4B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001359159.1 → NP_001346088.1  ectonucleoside triphosphate diphosphohydrolase 4B isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1). This locus is contained within a tandem segmental duplication. This sequence aligns equally well to ectonucleoside triphosphate diphosphohydrolase 4.
    Source sequence(s)
    AC160639, AC214054
    Consensus CDS
    CCDS88700.1
    UniProtKB/Swiss-Prot
    Q9DBT4
    UniProtKB/TrEMBL
    Q8CHF7
    Related
    ENSMUSP00000139202.2, ENSMUST00000185072.8
    Conserved Domains (1) summary
    cl17037
    Location:82 → 540
    NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily

  2. NM_001359160.1 → NP_001346089.1  ectonucleoside triphosphate diphosphohydrolase 4B isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the central coding region, compared to variant 1. The encoded isoform (2) has the same N- and C-termini, but is shorter than isoform 1. This locus is contained within a tandem segmental duplication. This sequence aligns equally well to ectonucleoside triphosphate diphosphohydrolase 4.
    Source sequence(s)
    AC160639, AC214054
    UniProtKB/TrEMBL
    Q8CHF7

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000080.7 Reference GRCm39 C57BL/6J

    Range
    69792850..69822389
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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