Cfap69 cilia and flagella associated protein 69 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Cfap69provided by RGD
Official Full Name: cilia and flagella associated protein 69provided by RGD
Primary source: RGD:6496360
See related: Ensembl:ENSRNOG00000006114 AllianceGenome:RGD:6496360
Gene type: protein coding
RefSeq status: MODEL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to be involved in several processes, including positive regulation of fertilization; positive regulation of flagellated sperm motility; and response to odorant. Predicted to act upstream of or within sperm axoneme assembly. Predicted to be located in cytoplasm. Predicted to be active in non-motile cilium and sperm midpiece. Human ortholog(s) of this gene implicated in spermatogenic failure 24. Orthologous to human CFAP69 (cilia and flagella associated protein 69). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Testes (RPKM 151.3), Brain (RPKM 43.7) and 5 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 4q13

Exon count:: 24

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	4	NC_086022.1 (29334624..29405513)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	4	NC_051339.1 (28379604..28452562)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	4	NC_005103.4 (25538513..25611470)

Chromosome 4 - NC_086022.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

RH132406 (e-PCR)
- UniSTS:215689

Homology

NCBI Orthologs

Orthologs from OrthoDB

Clone Names

MGC72627

Gene Ontology Provided by RGD

Process	Evidence Code	Pubs
acts_upstream_of_or_within flagellated sperm motility	ISO Inferred from Sequence Orthology more info
involved_in olfactory behavior	IBA Inferred from Biological aspect of Ancestor more info
involved_in olfactory behavior	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of fertilization	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of flagellated sperm motility	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of flagellated sperm motility	ISO Inferred from Sequence Orthology more info
involved_in response to odorant	IBA Inferred from Biological aspect of Ancestor more info
involved_in response to odorant	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within sperm axoneme assembly	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in non-motile cilium	IBA Inferred from Biological aspect of Ancestor more info
located_in non-motile cilium	ISO Inferred from Sequence Orthology more info
is_active_in sperm midpiece	IBA Inferred from Biological aspect of Ancestor more info
located_in sperm midpiece	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: cilia and flagella associated protein 69; cilia- and flagella-associated protein 69

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086022.1 Reference GRCr8

Range

29334624..29405513

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_003749688.6 → XP_003749736.1 cilia- and flagella-associated protein 69 isoform X1

See identical proteins and their annotated locations for XP_003749736.1

UniProtKB/TrEMBL

A0A8I6AJA3

Related

ENSRNOP00000093632.1
XM_063286814.1 → XP_063142884.1 cilia- and flagella-associated protein 69 isoform X2
XM_008762733.4 → XP_008760955.1 cilia- and flagella-associated protein 69 isoform X2

See identical proteins and their annotated locations for XP_008760955.1

UniProtKB/TrEMBL

A0A8I6AJA3
XM_008762734.4 → XP_008760956.1 cilia- and flagella-associated protein 69 isoform X2

See identical proteins and their annotated locations for XP_008760956.1

UniProtKB/TrEMBL

A0A8I6AJA3
XM_006236074.5 → XP_006236136.1 cilia- and flagella-associated protein 69 isoform X3

See identical proteins and their annotated locations for XP_006236136.1

UniProtKB/TrEMBL

A0A8I6AJA3
XM_039108576.2 → XP_038964504.1 cilia- and flagella-associated protein 69 isoform X4

UniProtKB/TrEMBL

A6K258

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_001007644.1: Suppressed sequence

Description

NM_001007644.1: This RefSeq was suppressed temporarily based on the calculation that the annotated protein was shorter than a protein or proteins from a putative ortholog.