Nupr1 nuclear protein 1, transcriptional regulator [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Nupr1provided by RGD
Official Full Name: nuclear protein 1, transcriptional regulatorprovided by RGD
Primary source: RGD:69363
See related: AllianceGenome:RGD:69363
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: p8; Nupr1l1
Summary: Predicted to enable several functions, including acetyltransferase activator activity; chromatin binding activity; and transcription coactivator activity. Involved in several processes, including negative regulation of DNA-binding transcription factor activity; negative regulation of autophagy; and regulation of apoptotic process. Predicted to be located in intercellular bridge; nucleoplasm; and perinuclear region of cytoplasm. Predicted to be part of protein-DNA complex. Predicted to be active in nucleus. Orthologous to human NUPR1 (nuclear protein 1, transcriptional regulator). [provided by Alliance of Genome Resources, Apr 2022]
Annotation information: Note: This single-copy gene is duplicated in the RGSC5.0 assembly; GeneID:100912108 represents the intended location for the rat Nupr1 gene while GeneID:113900 is most likely an artifact in the RGSC5.0 assembly, based on syntenic gene analysis. [17 Jun 2014]
Expression: Biased expression in Liver (RPKM 463.0), Kidney (RPKM 179.8) and 8 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 1q36

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (190643866..190645901, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (181213292..181215327, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (194767484..194769519, complement)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Multiparametric Evaluation of Post-MI Small Animal Models Using Metabolic ([(18)F]FDG) and Perfusion-Based (SYN1) Heart Viability Tracers.
Title: Multiparametric Evaluation of Post-MI Small Animal Models Using Metabolic ([(18)F]FDG) and Perfusion-Based (SYN1) Heart Viability Tracers.
Nupr1 silencing also reduced CSMC apoptosis.
Title: Epigenetic silencing of microRNA-874-3p implicates in erectile dysfunction in diabetic rats by activating the Nupr1/Chop-mediated pathway.
A role for the transcriptional regulator p8 in autophagy, is demonstrated.
Title: Deficiency of the transcriptional regulator p8 results in increased autophagy and apoptosis, and causes impaired heart function.
These results identify an unexpectedly broad involvement for p8 in key cellular events linked to cardiomyocyte hypertrophy and cardiac fibroblast matrix metalloproteases production, both of which occur in heart failure.
Title: Helix-loop-helix protein p8, a transcriptional regulator required for cardiomyocyte hypertrophy and cardiac fibroblast matrix metalloprotease induction.
TNFalpha-induced NF kappaB pathway contributes to the induction of p8 during pancreatitis and lipopolysaccharide-induced inflammation.
Title: Tumor necrosis factor alpha induces the expression of the nuclear protein p8 via a novel NF kappaB binding site within the promoter.
Astrocytes are sensitized to oxidative stress via a p38 mitogen-activated protein kinase-dependent p8 upregulation that leads in turn to decreased heme oxygenase 1 expression
Title: p8 Upregulation sensitizes astrocytes to oxidative stress.
strongly induced in ET-1-treated renal mesangial cells and in an animal model of diabetic nephropathy
Title: The pro-hypertrophic basic helix-loop-helix protein p8 is degraded by the ubiquitin/proteasome system in a protein kinase B/Akt- and glycogen synthase kinase-3-dependent manner, whereas endothelin induction of p8 mRNA and renal mesangial cell hypertrophy require NFAT4.
Incubation of rat INS-1 beta-cells with glucose resulted in cell division and upregulation of p8 mRNA.
Title: Nuclear protein p8 is associated with glucose-induced pancreatic beta-cell growth.
RNA interference indicates that p8 is required for endothelin-induced renal mesangial cell hypertrophy.
Title: Signaling pathways and late-onset gene induction associated with renal mesangial cell hypertrophy.

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables DNA binding	ISO Inferred from Sequence Orthology more info
enables DNA binding	ISS Inferred from Sequence or Structural Similarity more info
enables acetyltransferase activator activity	ISO Inferred from Sequence Orthology more info
enables acetyltransferase activator activity	ISS Inferred from Sequence or Structural Similarity more info
enables chromatin binding	ISO Inferred from Sequence Orthology more info
enables transcription coactivator activity	ISO Inferred from Sequence Orthology more info
enables transcription coactivator activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within acute inflammatory response	ISO Inferred from Sequence Orthology more info
acts_upstream_of fibroblast apoptotic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of fibroblast proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within male gonad development	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of apoptotic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of autophagosome assembly	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of autophagosome assembly	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of autophagy	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of autophagy	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of autophagy	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of cardiac muscle cell apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of cardiac muscle cell apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cardiac muscle cell apoptotic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of cell cycle	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within negative regulation of cell cycle	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of cell cycle	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of cell population proliferation	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of epithelial cell apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of epithelial cell apoptotic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of epithelial cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of epithelial cell proliferation	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within negative regulation of fibroblast proliferation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of glycolytic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of glycolytic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of programmed necrotic cell death	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of programmed necrotic cell death	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of type B pancreatic cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of type B pancreatic cell proliferation	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of cell cycle	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of fibroblast apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of intrinsic apoptotic signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of intrinsic apoptotic signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of intrinsic apoptotic signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of neuroinflammatory response	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of neuroinflammatory response	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of neuron apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of oxidative phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of oxidative phosphorylation	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of proteasomal protein catabolic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of proteasomal protein catabolic process	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within positive regulation of protein modification process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within protein-containing complex assembly	ISO Inferred from Sequence Orthology more info
involved_in regulation of autophagy	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of female gonad development	ISO Inferred from Sequence Orthology more info
involved_in regulation of response to endoplasmic reticulum stress	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of response to endoplasmic reticulum stress	ISO Inferred from Sequence Orthology more info
involved_in regulation of response to endoplasmic reticulum stress	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within response to toxic substance	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within skeletal muscle cell differentiation	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
located_in intercellular bridge	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info
located_in perinuclear region of cytoplasm	ISO Inferred from Sequence Orthology more info
located_in perinuclear region of cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
part_of protein-DNA complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: nuclear protein 1

Names: candidate of metastasis 1; nuclear protein 1-like; nuclear protein, transcriptional regulator, 1; nuclear protein, transcriptional regulator, 1-like 1; nuclear proten 1; nuclear transcriptional regulator protein 1; protein p8

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_053611.2 → NP_446063.1 nuclear protein 1

See identical proteins and their annotated locations for NP_446063.1

Status: VALIDATED

Source sequence(s)

AA685246, AF014503

UniProtKB/Swiss-Prot

O54842

UniProtKB/TrEMBL

A6I999

Conserved Domains (1) summary

pfam10195
Location:24 → 77

Phospho_p8; DNA-binding nuclear phosphoprotein p8