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BRCA1 BRCA1 DNA repair associated [ Felis catus (domestic cat) ]

Gene ID: 101081937, updated on 8-Mar-2024

Summary

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Official Symbol
BRCA1
Official Full Name
BRCA1 DNA repair associated
Primary source
VGNC:VGNC:60165
See related
EnsemblRapid:ENSFCTG00005008200
Gene type
protein coding
RefSeq status
MODEL
Organism
Felis catus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Feliformia; Felidae; Felinae; Felis
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: E1
Exon count:
25
Annotation release Status Assembly Chr Location
105 current F.catus_Fca126_mat1.0 (GCF_018350175.1) E1 NC_058381.1 (41522244..41581030, complement)
104 previous assembly Felis_catus_9.0 (GCF_000181335.3) E1 NC_018736.3 (43501000..43560918, complement)

Chromosome E1 - NC_058381.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC109494380 Neighboring gene Rho family GTPase 2 Neighboring gene NBR1 autophagy cargo receptor Neighboring gene uncharacterized LOC123382036 Neighboring gene transmembrane protein 106A Neighboring gene coiled-coil domain containing 200

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Parallel adaptive radiations in two major clades of placental mammals. Madsen O, et al. Nature, 2001 Feb 1. PMID 11214318

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables ubiquitin-protein transferase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in chordate embryonic development IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in dosage compensation by inactivation of X chromosome IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in double-strand break repair via homologous recombination IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in negative regulation of fatty acid biosynthetic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
part_of BRCA1-A complex IEA
Inferred from Electronic Annotation
more info
 PubMed 
part_of BRCA1-BARD1 complex IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
breast cancer type 1 susceptibility protein
Names
breast cancer 1, early onset
breast cancer type 1 susceptibility protein homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Felis catus Annotation Release 105 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference F.catus_Fca126_mat1.0 Primary Assembly

Genomic

  1. NC_058381.1 Reference F.catus_Fca126_mat1.0 Primary Assembly

    Range
    41522244..41581030 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_019817934.2 → XP_019673493.2  breast cancer type 1 susceptibility protein isoform X1

    UniProtKB/TrEMBL
    M3WIB0
    Conserved Domains (4) summary
    COG5432
    Location:15 → 122
    RAD18; RING-finger-containing E3 ubiquitin ligase [Signal transduction mechanisms]
    cd16498
    Location:18 → 65
    RING-HC_BRCA1; RING finger, HC subclass, found in breast cancer type 1 susceptibility protein (BRCA1) and similar proteins
    cd17721
    Location:1761 → 1858
    BRCT_BRCA1_rpt2; second (C-terminal) BRCT domain of breast cancer type 1 susceptibility protein (BRCA1) and similar proteins
    cd17735
    Location:1653 → 1749
    BRCT_BRCA1_rpt1; first BRCT domain of breast cancer type 1 susceptibility protein (BRCA1) and similar proteins

  2. XM_045044988.1 → XP_044900923.1  breast cancer type 1 susceptibility protein isoform X1

    UniProtKB/TrEMBL
    M3WIB0
    Conserved Domains (4) summary
    COG5432
    Location:15 → 122
    RAD18; RING-finger-containing E3 ubiquitin ligase [Signal transduction mechanisms]
    cd16498
    Location:18 → 65
    RING-HC_BRCA1; RING finger, HC subclass, found in breast cancer type 1 susceptibility protein (BRCA1) and similar proteins
    cd17721
    Location:1761 → 1858
    BRCT_BRCA1_rpt2; second (C-terminal) BRCT domain of breast cancer type 1 susceptibility protein (BRCA1) and similar proteins
    cd17735
    Location:1653 → 1749
    BRCT_BRCA1_rpt1; first BRCT domain of breast cancer type 1 susceptibility protein (BRCA1) and similar proteins

  3. XM_045044991.1 → XP_044900926.1  breast cancer type 1 susceptibility protein isoform X4

    UniProtKB/TrEMBL
    M3WIB0
    Related
    ENSFCTP00005014981.1, ENSFCTT00005022972.1
    Conserved Domains (4) summary
    TIGR00599
    Location:15 → 156
    rad18; DNA repair protein rad18
    cd16498
    Location:18 → 65
    RING-HC_BRCA1; RING finger, HC subclass, found in breast cancer type 1 susceptibility protein (BRCA1) and similar proteins
    cd17721
    Location:1759 → 1856
    BRCT_BRCA1_rpt2; second (C-terminal) BRCT domain of breast cancer type 1 susceptibility protein (BRCA1) and similar proteins
    cd17735
    Location:1651 → 1747
    BRCT_BRCA1_rpt1; first BRCT domain of breast cancer type 1 susceptibility protein (BRCA1) and similar proteins

  4. XM_045044990.1 → XP_044900925.1  breast cancer type 1 susceptibility protein isoform X3

    UniProtKB/TrEMBL
    M3WIB0
    Conserved Domains (4) summary
    TIGR00599
    Location:15 → 156
    rad18; DNA repair protein rad18
    cd16498
    Location:18 → 65
    RING-HC_BRCA1; RING finger, HC subclass, found in breast cancer type 1 susceptibility protein (BRCA1) and similar proteins
    cd17721
    Location:1760 → 1857
    BRCT_BRCA1_rpt2; second (C-terminal) BRCT domain of breast cancer type 1 susceptibility protein (BRCA1) and similar proteins
    cd17735
    Location:1652 → 1748
    BRCT_BRCA1_rpt1; first BRCT domain of breast cancer type 1 susceptibility protein (BRCA1) and similar proteins

  5. XM_045044993.1 → XP_044900928.1  breast cancer type 1 susceptibility protein isoform X6

    UniProtKB/TrEMBL
    A0A337S3M9
    Related
    ENSFCTP00005014958.1, ENSFCTT00005022939.1
    Conserved Domains (4) summary
    COG5432
    Location:15 → 122
    RAD18; RING-finger-containing E3 ubiquitin ligase [Signal transduction mechanisms]
    cd16498
    Location:18 → 65
    RING-HC_BRCA1; RING finger, HC subclass, found in breast cancer type 1 susceptibility protein (BRCA1) and similar proteins
    cd17721
    Location:653 → 750
    BRCT_BRCA1_rpt2; second (C-terminal) BRCT domain of breast cancer type 1 susceptibility protein (BRCA1) and similar proteins
    cd17735
    Location:545 → 641
    BRCT_BRCA1_rpt1; first BRCT domain of breast cancer type 1 susceptibility protein (BRCA1) and similar proteins

  6. XM_045044992.1 → XP_044900927.1  breast cancer type 1 susceptibility protein isoform X5

    UniProtKB/TrEMBL
    A0A337S3M9
    Related
    ENSFCTP00005015000.1, ENSFCTT00005023004.1
    Conserved Domains (4) summary
    COG5432
    Location:15 → 122
    RAD18; RING-finger-containing E3 ubiquitin ligase [Signal transduction mechanisms]
    cd16498
    Location:18 → 65
    RING-HC_BRCA1; RING finger, HC subclass, found in breast cancer type 1 susceptibility protein (BRCA1) and similar proteins
    cd17721
    Location:654 → 751
    BRCT_BRCA1_rpt2; second (C-terminal) BRCT domain of breast cancer type 1 susceptibility protein (BRCA1) and similar proteins
    cd17735
    Location:546 → 642
    BRCT_BRCA1_rpt1; first BRCT domain of breast cancer type 1 susceptibility protein (BRCA1) and similar proteins

  7. XM_045044989.1 → XP_044900924.1  breast cancer type 1 susceptibility protein isoform X2

    UniProtKB/TrEMBL
    M3WIB0
    Conserved Domains (4) summary
    COG5432
    Location:15 → 122
    RAD18; RING-finger-containing E3 ubiquitin ligase [Signal transduction mechanisms]
    cd16498
    Location:18 → 65
    RING-HC_BRCA1; RING finger, HC subclass, found in breast cancer type 1 susceptibility protein (BRCA1) and similar proteins
    cd17721
    Location:1760 → 1857
    BRCT_BRCA1_rpt2; second (C-terminal) BRCT domain of breast cancer type 1 susceptibility protein (BRCA1) and similar proteins
    cd17735
    Location:1652 → 1748
    BRCT_BRCA1_rpt1; first BRCT domain of breast cancer type 1 susceptibility protein (BRCA1) and similar proteins

  8. XM_019817933.3 → XP_019673492.2  breast cancer type 1 susceptibility protein isoform X1

    UniProtKB/TrEMBL
    M3WIB0
    Related
    ENSFCTP00005014933.1, ENSFCTT00005022901.1
    Conserved Domains (4) summary
    COG5432
    Location:15 → 122
    RAD18; RING-finger-containing E3 ubiquitin ligase [Signal transduction mechanisms]
    cd16498
    Location:18 → 65
    RING-HC_BRCA1; RING finger, HC subclass, found in breast cancer type 1 susceptibility protein (BRCA1) and similar proteins
    cd17721
    Location:1761 → 1858
    BRCT_BRCA1_rpt2; second (C-terminal) BRCT domain of breast cancer type 1 susceptibility protein (BRCA1) and similar proteins
    cd17735
    Location:1653 → 1749
    BRCT_BRCA1_rpt1; first BRCT domain of breast cancer type 1 susceptibility protein (BRCA1) and similar proteins

  9. XM_045044987.1 → XP_044900922.1  breast cancer type 1 susceptibility protein isoform X1

    UniProtKB/TrEMBL
    M3WIB0
    Conserved Domains (4) summary
    COG5432
    Location:15 → 122
    RAD18; RING-finger-containing E3 ubiquitin ligase [Signal transduction mechanisms]
    cd16498
    Location:18 → 65
    RING-HC_BRCA1; RING finger, HC subclass, found in breast cancer type 1 susceptibility protein (BRCA1) and similar proteins
    cd17721
    Location:1761 → 1858
    BRCT_BRCA1_rpt2; second (C-terminal) BRCT domain of breast cancer type 1 susceptibility protein (BRCA1) and similar proteins
    cd17735
    Location:1653 → 1749
    BRCT_BRCA1_rpt1; first BRCT domain of breast cancer type 1 susceptibility protein (BRCA1) and similar proteins
Nucleotide Protein
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