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dmrt1 doublesex and mab-3 related transcription factor 1 [ Oryzias latipes (Japanese medaka) ]

Gene ID: 101161472, updated on 8-Mar-2024

Summary

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Gene symbol
dmrt1
Gene description
doublesex and mab-3 related transcription factor 1
See related
EnsemblRapid:ENSORLG00000020817
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Oryzias latipes
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata; Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae; Oryziinae; Oryzias
Also known as
dmy; DMRT1Y; dmrt1a; Dmrt1-A; Dmrt1-C
Orthologs
zebrafish all
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Genomic context

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Location:
chromosome: 9
Exon count:
6
Annotation release Status Assembly Chr Location
103 current ASM223467v1 (GCF_002234675.1) 9 NC_019867.2 (1177806..1215534, complement)
102 previous assembly ASM31367v1 (GCF_000313675.1) Unplaced Scaffold NW_004095176.1 (169639..204570)

Chromosome 9 - NC_019867.2Genomic Context describing neighboring genes Neighboring gene doublesex and mab-3 related transcription factor 2a Neighboring gene doublesex and mab-3 related transcription factor 3a Neighboring gene uncharacterized LOC110014729 Neighboring gene uncharacterized LOC111947863 Neighboring gene uncharacterized LOC110014618 Neighboring gene uncharacterized LOC110014730 Neighboring gene KN motif and ankyrin repeat domains 1a Neighboring gene fructose-1,6-bisphosphatase 1a

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Increase of cortisol levels after temperature stress activates dmrt1a causing female-to-male sex reversal and reduced germ cell number in medaka. Adolfi MC, et al. Mol Reprod Dev, 2019 Oct. PMID 31140678
  2. Dmy initiates masculinity by altering Gsdf/Sox9a2/Rspo1 expression in medaka (Oryzias latipes). Chakraborty T, et al. Sci Rep, 2016 Jan 25. PMID 26806354, Free PMC Article
  3. Evidence for different origins of sex chromosomes in closely related Oryzias fishes: substitution of the master sex-determining gene. Tanaka K, et al. Genetics, 2007 Dec. PMID 17947439, Free PMC Article
  4. Absence of the candidate male sex-determining gene dmrt1b(Y) of medaka from other fish species. Kondo M, et al. Curr Biol, 2003 Mar 4. PMID 12620191
  5. DMY is a Y-specific DM-domain gene required for male development in the medaka fish. Matsuda M, et al. Nature, 2002 May 30. PMID 12037570

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. In this study, we investigated the mechanisms regulating germ cell proliferation in embryos of medaka and the effect of temperature and cortisol on natural sex determination; found increased cortisol activates doublesex and mab-3 related transcription factor 1 (dmrt1a.)
    Title: Increase of cortisol levels after temperature stress activates dmrt1a causing female-to-male sex reversal and reduced germ cell number in medaka.
  2. Dmy knockdown (Dmy-KD) suppressed male pathway (Gsdf, Sox9a2, etc.) and favoured female cascade (Rspo1, etc.) in embryonic XY gonads, resulting in a fertile male-to-female sex-reversal.
    Title: Dmy initiates masculinity by altering Gsdf/Sox9a2/Rspo1 expression in medaka (Oryzias latipes).
  3. These data provide functional evidence for a role of transposable elements in transcriptional network rewiring for sub- and/or neo-functionalization of duplicated genes like dmy.
    Title: Transcriptional rewiring of the sex determining dmrt1 gene duplicate by transposable elements.
  4. model for evolution of the master sex-determining gene and differentiation of sex chromosomes from autosomes
    Title: Evidence for different origins of sex chromosomes in closely related Oryzias fishes: substitution of the master sex-determining gene.
  5. androgen-induced XX sex-reversal proceeds via an androgen-Gsdf-Dmrt1 cascade and that Gsdf plays an important role in sex-reversal in medaka.
    Title: Androgen induces gonadal soma-derived factor, Gsdf, in XX gonads correlated to sex-reversal but not Dmrt1 directly, in the teleost fish, northern medaka (Oryzias sakaizumii).
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General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in sex differentiation IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
doublesex- and mab-3-related transcription factor 1
Names
Doublesex- and mab-3-related transcription factor 1Y
Y-linked doublesex- and mab-3-related transcription factor
Y-specific doublesex- and mab-3-related transcription factor
doublesex and mab-3 related transcription factor 1 c
male sex-determining protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001104680.2 → NP_001098150.2  doublesex- and mab-3-related transcription factor 1

    Status: VALIDATED

    Source sequence(s)
    CP020673
    UniProtKB/Swiss-Prot
    Q801F8, Q90XZ5, Q90XZ8
    UniProtKB/TrEMBL
    A0A3B3I1V1
    Conserved Domains (2) summary
    pfam00751
    Location:23 → 69
    DM; DM DNA binding domain
    pfam12374
    Location:81 → 149
    Dmrt1; Double-sex mab3 related transcription factor 1

RefSeqs of Annotated Genomes: Oryzias latipes Annotation Release 103 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ASM223467v1 Primary Assembly

Genomic

  1. NC_019867.2 Reference ASM223467v1 Primary Assembly

    Range
    1177806..1215534 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_023958133.1 → XP_023813901.1  doublesex- and mab-3-related transcription factor 1 isoform X1

    UniProtKB/Swiss-Prot
    Q801F8, Q90XZ5, Q90XZ8
    UniProtKB/TrEMBL
    A0A3B3I1V1
    Related
    ENSORLP00000025780.2, ENSORLT00000025781.3
    Conserved Domains (2) summary
    pfam00751
    Location:23 → 69
    DM; DM DNA binding domain
    pfam12374
    Location:81 → 149
    Dmrt1; Double-sex mab3 related transcription factor 1

  2. XM_004086451.4 → XP_004086499.1  doublesex- and mab-3-related transcription factor 1 isoform X2

    UniProtKB/TrEMBL
    A0A3P9MA27
    Conserved Domains (2) summary
    pfam00751
    Location:23 → 69
    DM; DM DNA binding domain
    pfam12374
    Location:81 → 149
    Dmrt1; Double-sex mab3 related transcription factor 1

  3. XM_020701694.2 → XP_020557353.1  doublesex- and mab-3-related transcription factor 1 isoform X1

    Related
    ENSORLP00000038084.1, ENSORLT00000036289.1
    Conserved Domains (2) summary
    pfam00751
    Location:23 → 69
    DM; DM DNA binding domain
    pfam12374
    Location:81 → 149
    Dmrt1; Double-sex mab3 related transcription factor 1
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q801F8.1 GenPept UniProtKB/Swiss-Prot:Q801F8

Gene LinkOut

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