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Dyrk4 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 4 [ Mus musculus (house mouse) ]

Gene ID: 101320, updated on 5-Jan-2022

Summary

Official Symbol
Dyrk4provided by MGI
Official Full Name
dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 4provided by MGI
Primary source
MGI:MGI:1330292
See related
Ensembl:ENSMUSG00000030345
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Dyrk4a; Dyrk4b; AW049118
Summary
Predicted to enable protein serine/threonine kinase activity. Predicted to be involved in peptidyl-serine phosphorylation and peptidyl-threonine phosphorylation. Predicted to act upstream of or within phosphorylation. Predicted to be located in intracellular membrane-bounded organelle. Predicted to be active in cytoplasm; cytoskeleton; and nucleus. Orthologous to human DYRK4 (dual specificity tyrosine phosphorylation regulated kinase 4). [provided by Alliance of Genome Resources, Nov 2021]
Expression
Restricted expression toward testis adult (RPKM 6.9) See more
Orthologs
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Genomic context

See Dyrk4 in Genome Data Viewer
Location:
6; 6 F3
Exon count:
19
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (126852983..126899039, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (126876020..126922083, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 6 NC_000072.5 (126826217..126871857, complement)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 1700018A23 gene Neighboring gene NADH:ubiquinone oxidoreductase subunit A9 Neighboring gene A kinase (PRKA) anchor protein 3 Neighboring gene RAD51 associated protein 1 Neighboring gene metaxin 1 pseudogene Neighboring gene DNA segment, Chr 6, Wayne State University 163, expressed

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein serine/threonine/tyrosine kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in peptidyl-serine phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in peptidyl-threonine phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
 
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
is_active_in cytoskeleton IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
dual specificity tyrosine-phosphorylation-regulated kinase 4
NP_997093.2
XP_006505316.1
XP_006505318.1
XP_006505319.1
XP_011239406.1
XP_011239407.1
XP_011239409.1
XP_036021600.1
XP_036021601.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_207210.2NP_997093.2  dual specificity tyrosine-phosphorylation-regulated kinase 4

    See identical proteins and their annotated locations for NP_997093.2

    Status: VALIDATED

    Source sequence(s)
    AK077117, BC052324
    Consensus CDS
    CCDS20559.2
    UniProtKB/Swiss-Prot
    Q8BI55
    Related
    ENSMUSP00000077606.6, ENSMUST00000078521.7
    Conserved Domains (2) summary
    smart00220
    Location:219515
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14225
    Location:175515
    PKc_DYRK4; Catalytic domain of the protein kinase, Dual-specificity tYrosine-phosphorylated and -Regulated Kinase 4

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    126852983..126899039 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011241105.3XP_011239407.1  dual specificity tyrosine-phosphorylation-regulated kinase 4 isoform X2

    Conserved Domains (1) summary
    cd14225
    Location:218558
    PKc_DYRK4; Catalytic domain of the protein kinase, Dual-specificity tYrosine-phosphorylated and -Regulated Kinase 4
  2. XM_011241104.3XP_011239406.1  dual specificity tyrosine-phosphorylation-regulated kinase 4 isoform X1

    Conserved Domains (1) summary
    cd14225
    Location:228568
    PKc_DYRK4; Catalytic domain of the protein kinase, Dual-specificity tYrosine-phosphorylated and -Regulated Kinase 4
  3. XM_006505255.3XP_006505318.1  dual specificity tyrosine-phosphorylation-regulated kinase 4 isoform X4

    Conserved Domains (1) summary
    cd14225
    Location:185525
    PKc_DYRK4; Catalytic domain of the protein kinase, Dual-specificity tYrosine-phosphorylated and -Regulated Kinase 4
  4. XM_006505253.1XP_006505316.1  dual specificity tyrosine-phosphorylation-regulated kinase 4 isoform X3

    See identical proteins and their annotated locations for XP_006505316.1

    Conserved Domains (1) summary
    cd14225
    Location:209549
    PKc_DYRK4; Catalytic domain of the protein kinase, Dual-specificity tYrosine-phosphorylated and -Regulated Kinase 4
  5. XM_006505256.5XP_006505319.1  dual specificity tyrosine-phosphorylation-regulated kinase 4 isoform X5

    Related
    ENSMUST00000032495.10
    Conserved Domains (1) summary
    cd14225
    Location:149489
    PKc_DYRK4; Catalytic domain of the protein kinase, Dual-specificity tYrosine-phosphorylated and -Regulated Kinase 4
  6. XM_036165708.1XP_036021601.1  dual specificity tyrosine-phosphorylation-regulated kinase 4 isoform X8

    Conserved Domains (1) summary
    cl21453
    Location:1232
    PKc_like; Protein Kinases, catalytic domain
  7. XM_011241107.3XP_011239409.1  dual specificity tyrosine-phosphorylation-regulated kinase 4 isoform X7

    Conserved Domains (1) summary
    cl21453
    Location:228486
    PKc_like; Protein Kinases, catalytic domain
  8. XM_036165707.1XP_036021600.1  dual specificity tyrosine-phosphorylation-regulated kinase 4 isoform X6

    Conserved Domains (1) summary
    cl21453
    Location:228488
    PKc_like; Protein Kinases, catalytic domain
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