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pappab pregnancy-associated plasma protein A, pappalysin 1b [ Danio rerio (zebrafish) ]

Gene ID: 101448001, updated on 27-Mar-2024

Summary

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Official Symbol
pappabprovided by ZNC
Official Full Name
pregnancy-associated plasma protein A, pappalysin 1bprovided by ZNC
Primary source
ZFIN:ZDB-GENE-060526-71
See related
Ensembl:ENSDARG00000059858 AllianceGenome:ZFIN:ZDB-GENE-060526-71
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
si:ch211-196f15.1
Summary
Enables peptidase activity. Acts upstream of or within chordate embryonic development. Is expressed in several structures, including digestive system; muscle; nervous system; pleuroperitoneal region; and skeletal tissue. Human ortholog(s) of this gene implicated in myocardial infarction. Orthologous to human PAPPA (pappalysin 1). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
all
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Genomic context

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Location:
chromosome: 5
Exon count:
22
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 5 NC_007116.7 (63912792..64104243, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 5 NC_007116.6 (63231378..63423282, complement)

Chromosome 5 - NC_007116.7Genomic Context describing neighboring genes Neighboring gene dynamin 1b Neighboring gene regulator of G protein signaling 3b Neighboring gene cardiac myosin light chain-1 Neighboring gene adenylate kinase 5, like

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. The metalloproteinase Papp-aa controls epithelial cell quiescence-proliferation transition. Liu C, et al. Elife, 2020 Apr 16. PMID 32293560, Free PMC Article
  2. Pregnancy-associated plasma protein A (PAPP-A) modulates the early developmental rate in zebrafish independently of its proteolytic activity. Kjaer-Sorensen K, et al. J Biol Chem, 2013 Apr 5. PMID 23430244, Free PMC Article
  3. Endoglin controls blood vessel diameter through endothelial cell shape changes in response to haemodynamic cues. Sugden WW, et al. Nat Cell Biol, 2017 Jun. PMID 28530658, Free PMC Article
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables metalloendopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metallopeptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables peptidase activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in cell surface receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within chordate embryonic development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in proteolysis IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
pregnancy-associated plasma protein A, pappalysin 1b

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001278808.1 → NP_001265737.1  pregnancy-associated plasma protein A, pappalysin 1b precursor

    See identical proteins and their annotated locations for NP_001265737.1

    Status: PROVISIONAL

    Source sequence(s)
    HE999622
    UniProtKB/TrEMBL
    M1WXG8
    Related
    ENSDARP00000078119.5, ENSDART00000083684.6
    Conserved Domains (7) summary
    cd00033
    Location:1275 → 1333
    CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
    smart00004
    Location:1545 → 1581
    NL; Domain found in Notch and Lin-12
    TIGR02232
    Location:937 → 976
    myxo_disulf_rpt; Myxococcus cysteine-rich repeat
    cd04275
    Location:416 → 652
    ZnMc_pappalysin_like; Zinc-dependent metalloprotease, pappalysin_like subfamily. The pregnancy-associated plasma protein A (PAPP-A or pappalysin-1) cleaves insulin-like growth factor-binding proteins 4 and 5, thereby promoting cell growth by releasing bound growth factor. ...
    pfam00084
    Location:1412 → 1467
    Sushi; Sushi repeat (SCR repeat)
    pfam13385
    Location:90 → 257
    Laminin_G_3; Concanavalin A-like lectin/glucanases superfamily
    pfam13948
    Location:938 → 969
    DUF4215; Domain of unknown function (DUF4215)

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007116.7 Reference GRCz11 Primary Assembly

    Range
    63912792..64104243 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_009301935.3 → XP_009300210.1  pregnancy-associated plasma protein A, pappalysin 1b isoform X1

    UniProtKB/TrEMBL
    A0A8M3ASU7
    Conserved Domains (7) summary
    cd00033
    Location:1275 → 1333
    CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
    smart00004
    Location:1554 → 1590
    NL; Domain found in Notch and Lin-12
    TIGR02232
    Location:937 → 976
    myxo_disulf_rpt; Myxococcus cysteine-rich repeat
    cd04275
    Location:416 → 652
    ZnMc_pappalysin_like; Zinc-dependent metalloprotease, pappalysin_like subfamily. The pregnancy-associated plasma protein A (PAPP-A or pappalysin-1) cleaves insulin-like growth factor-binding proteins 4 and 5, thereby promoting cell growth by releasing bound growth factor. ...
    pfam00084
    Location:1336 → 1407
    Sushi; Sushi repeat (SCR repeat)
    pfam13385
    Location:90 → 257
    Laminin_G_3; Concanavalin A-like lectin/glucanases superfamily
    pfam13948
    Location:938 → 969
    DUF4215; Domain of unknown function (DUF4215)
Nucleotide Protein Strain
Heading Accession and Version

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Molecular Biology Databases