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MMP12 matrix metallopeptidase 12 [ Mustela putorius furo (domestic ferret) ]

Gene ID: 101688224, updated on 8-Mar-2024

Summary

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Gene symbol
MMP12
Gene description
matrix metallopeptidase 12
See related
Ensembl:ENSMPUG00000006848
Gene type
protein coding
RefSeq status
MODEL
Organism
Mustela putorius furo (sub-species: furo)
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Musteloidea; Mustelidae; Mustelinae; Mustela
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: Un
Exon count:
11
Annotation release Status Assembly Chr Location
102 current ASM1176430v1.1 (GCF_011764305.1) Unplaced Scaffold NW_025421311.1 (1088140..1099703, complement)
101 previous assembly MusPutFur1.0 (GCF_000215625.1) Unplaced Scaffold NW_004569248.1 (6085696..6097239)

NW_025421311.1Genomic Context describing neighboring genes Neighboring gene interstitial collagenase Neighboring gene stromelysin-1 Neighboring gene matrix metallopeptidase 13 Neighboring gene uncharacterized LOC123391315

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. De-novo transcriptome sequencing of a normalized cDNA pool from influenza infected ferrets. Camp JV, et al. PLoS One, 2012. PMID 22606336, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables metalloendopeptidase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in collagen catabolic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in extracellular matrix organization IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in extracellular matrix IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
macrophage metalloelastase
Names
matrix metallopeptidase 12 (macrophage elastase)

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Mustela putorius furo Annotation Release 102 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ASM1176430v1.1 Primary Assembly

Genomic

  1. NW_025421311.1 Reference ASM1176430v1.1 Primary Assembly

    Range
    1088140..1099703 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_004764450.3 → XP_004764507.1  macrophage metalloelastase

    UniProtKB/TrEMBL
    G9KAW9, M3Y643
    Related
    ENSMPUP00000006794.1
    Conserved Domains (4) summary
    cd00094
    Location:306 → 493
    HX; Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of ...
    cd04278
    Location:133 → 287
    ZnMc_MMP; Zinc-dependent metalloprotease, matrix metalloproteinase (MMP) sub-family. MMPs are responsible for a great deal of pericellular proteolysis of extracellular matrix and cell surface molecules, playing crucial roles in morphogenesis, cell fate ...
    pfam00413
    Location:133 → 287
    Peptidase_M10; Matrixin
    pfam01471
    Location:50 → 111
    PG_binding_1; Putative peptidoglycan binding domain
Nucleotide Protein
Heading Accession and Version

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