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Blk BLK proto-oncogene, Src family tyrosine kinase [ Heterocephalus glaber (naked mole-rat) ]

Gene ID: 101707209, updated on 11-Apr-2024

Summary

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Gene symbol
Blk
Gene description
BLK proto-oncogene, Src family tyrosine kinase
Locus tag
GW7_15136
See related
Ensembl:ENSHGLG00000015762
Gene type
protein coding
RefSeq status
MODEL
Organism
Heterocephalus glaber
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Bathyergidae; Heterocephalus
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: Un
Exon count:
13
Annotation release Status Assembly Chr Location
102 current HetGla_female_1.0 (GCF_000247695.1) Unplaced Scaffold NW_004624758.1 (25129922..25180180)

NW_004624758.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC101706364 Neighboring gene family with sequence similarity 167 member A Neighboring gene uncharacterized LOC110350058 Neighboring gene collagen alpha-1(I) chain-like

Genomic regions, transcripts, and products

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Genomic Sequence:
NW_004624758 Unplaced Scaffold Reference HetGla_female_1.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Genome sequencing reveals insights into physiology and longevity of the naked mole rat. Kim EB, et al. Nature, 2011 Oct 12. PMID 21993625, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables non-membrane spanning protein tyrosine kinase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables signaling receptor binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in cell differentiation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in cell surface receptor protein tyrosine kinase signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in innate immune response IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in extrinsic component of cytoplasmic side of plasma membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
tyrosine-protein kinase Blk
Names
B lymphoid tyrosine kinase
Tyrosine-protein kinase BLK

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Heterocephalus glaber Annotation Release 102 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference HetGla_female_1.0 Primary Assembly

Genomic

  1. NW_004624758.1 Reference HetGla_female_1.0 Primary Assembly

    Range
    25129922..25180180
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_004848453.2 → XP_004848510.1  tyrosine-protein kinase Blk isoform X2

    UniProtKB/TrEMBL
    G5AMF8
    Related
    ENSHGLP00000022090.1, ENSHGLT00000022301.1
    Conserved Domains (4) summary
    pfam07714
    Location:235 → 484
    Pkinase_Tyr; Protein tyrosine kinase
    cl15255
    Location:114 → 213
    SH2; Src homology 2 (SH2) domain
    cl17036
    Location:56 → 109
    SH3; Src Homology 3 domain superfamily
    cl21453
    Location:227 → 490
    PKc_like; Protein Kinases, catalytic domain

  2. XM_021261362.1 → XP_021117021.1  tyrosine-protein kinase Blk isoform X1

    UniProtKB/TrEMBL
    G5AMF8
    Conserved Domains (3) summary
    cl15255
    Location:146 → 245
    SH2; Src homology 2 (SH2) domain
    cl17036
    Location:88 → 141
    SH3; Src Homology 3 domain superfamily
    cl21453
    Location:259 → 522
    PKc_like; Protein Kinases, catalytic domain

  3. XM_021261363.1 → XP_021117022.1  tyrosine-protein kinase Blk isoform X3

    Conserved Domains (3) summary
    cl15255
    Location:146 → 196
    SH2; Src homology 2 (SH2) domain
    cl17036
    Location:88 → 141
    SH3; Src Homology 3 domain superfamily
    cl21453
    Location:210 → 473
    PKc_like; Protein Kinases, catalytic domain
Nucleotide Protein
Heading Accession and Version

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