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Actn4 actinin alpha 4 [ Mesocricetus auratus (golden hamster) ]

Gene ID: 101841237, updated on 8-Mar-2024

Summary

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Gene symbol
Actn4
Gene description
actinin alpha 4
See related
EnsemblRapid:ENSMAUG00000001137
Gene type
protein coding
RefSeq status
MODEL
Organism
Mesocricetus auratus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Cricetidae; Cricetinae; Mesocricetus
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: Un
Exon count:
23
Annotation release Status Assembly Chr Location
103 current BCM_Maur_2.0 (GCF_017639785.1) Unplaced Scaffold NW_024429216.1 (6569194..6634445)
102 previous assembly MesAur1.0 (GCF_000349665.1) Unplaced Scaffold NW_004801819.1 (1212597..1277637)

NW_024429216.1Genomic Context describing neighboring genes Neighboring gene mitogen-activated protein kinase kinase kinase kinase 1 Neighboring gene eukaryotic translation initiation factor 3 subunit K Neighboring gene uncharacterized LOC121135550 Neighboring gene uncharacterized LOC121135548 Neighboring gene calpain 12 Neighboring gene galectin-7

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Transcriptome sequencing and development of an expression microarray platform for liver infection in adenovirus type 5-infected Syrian golden hamsters. Ying B, et al. Virology, 2015 Nov. PMID 26319212, Free PMC Article
  2. De novo assembly, annotation, and characterization of the whole brain transcriptome of male and female Syrian hamsters. McCann KE, et al. Sci Rep, 2017 Jan 10. PMID 28071753, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables actin filament binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in actin cytoskeleton organization IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in muscle cell development IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in Z disc IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in cell junction IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in cell projection IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in cortical actin cytoskeleton IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
alpha-actinin-4

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Mesocricetus auratus Annotation Release 103 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference BCM_Maur_2.0 Primary Assembly

Genomic

  1. NW_024429216.1 Reference BCM_Maur_2.0 Primary Assembly

    Range
    6569194..6634445
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_040734573.1 → XP_040590507.1  alpha-actinin-4 isoform X4

    Related
    ENSMAUP00000050316.1, ENSMAUT00000051321.1
    Conserved Domains (3) summary
    COG5069
    Location:48 → 311
    SAC6; Ca2+-binding actin-bundling protein fimbrin/plastin (EF-Hand superfamily) [Cytoskeleton]
    COG5126
    Location:762 → 866
    FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]
    cd00176
    Location:414 → 640
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

  2. XM_040734575.1 → XP_040590509.1  alpha-actinin-4 isoform X6

    UniProtKB/TrEMBL
    A0A3Q0CD83
    Related
    ENSMAUP00000057098.1, ENSMAUT00000064947.1
    Conserved Domains (5) summary
    COG5126
    Location:762 → 893
    FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]
    cd00176
    Location:414 → 640
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    pfam08726
    Location:863 → 929
    EFhand_Ca_insen; Ca2+ insensitive EF hand
    cd21214
    Location:47 → 151
    CH_ACTN_rpt1; first calponin homology (CH) domain found in the alpha-actinin family
    cd21216
    Location:155 → 269
    CH_ACTN_rpt2; second calponin homology (CH) domain found in the alpha-actinin family

  3. XM_040734572.1 → XP_040590506.1  alpha-actinin-4 isoform X3

    Conserved Domains (3) summary
    COG5069
    Location:48 → 311
    SAC6; Ca2+-binding actin-bundling protein fimbrin/plastin (EF-Hand superfamily) [Cytoskeleton]
    COG5126
    Location:762 → 866
    FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]
    cd00176
    Location:414 → 640
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

  4. XM_040734574.1 → XP_040590508.1  alpha-actinin-4 isoform X5

    Conserved Domains (3) summary
    PTZ00184
    Location:759 → 841
    PTZ00184; calmodulin; Provisional
    COG5069
    Location:48 → 311
    SAC6; Ca2+-binding actin-bundling protein fimbrin/plastin (EF-Hand superfamily) [Cytoskeleton]
    cd00176
    Location:414 → 640
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

  5. XM_040734571.1 → XP_040590505.1  alpha-actinin-4 isoform X2

    Conserved Domains (3) summary
    PTZ00184
    Location:759 → 868
    PTZ00184; calmodulin; Provisional
    COG5069
    Location:48 → 311
    SAC6; Ca2+-binding actin-bundling protein fimbrin/plastin (EF-Hand superfamily) [Cytoskeleton]
    cd00176
    Location:414 → 640
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

  6. XM_040734570.1 → XP_040590504.1  alpha-actinin-4 isoform X1

    Related
    ENSMAUP00000028989.1, ENSMAUT00000069177.1
    Conserved Domains (3) summary
    PTZ00184
    Location:759 → 868
    PTZ00184; calmodulin; Provisional
    COG5069
    Location:48 → 311
    SAC6; Ca2+-binding actin-bundling protein fimbrin/plastin (EF-Hand superfamily) [Cytoskeleton]
    cd00176
    Location:414 → 640
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
Nucleotide Protein Strain
Heading Accession and Version

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