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itgam.1 integrin, alpha M (complement component 3 receptor 3 subunit), tandem duplicate 1 [ Danio rerio (zebrafish) ]

Gene ID: 101882585, updated on 27-Mar-2024

Summary

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Official Symbol
itgam.1provided by ZNC
Official Full Name
integrin, alpha M (complement component 3 receptor 3 subunit), tandem duplicate 1provided by ZNC
Primary source
ZFIN:ZDB-GENE-110411-175
See related
Ensembl:ENSDARG00000002956 AllianceGenome:ZFIN:ZDB-GENE-110411-175
Gene type
protein coding
RefSeq status
MODEL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
cd11b; si:dkey-32n7.4
Summary
Predicted to enable metal ion binding activity. Predicted to act upstream of or within cell adhesion and integrin-mediated signaling pathway. Predicted to be located in membrane. Predicted to be integral component of membrane. Predicted to be part of integrin complex. Is expressed in brain. Human ortholog(s) of this gene implicated in lupus nephritis. Orthologous to several human genes including ITGAX (integrin subunit alpha X). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
all
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Genomic context

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Location:
chromosome: 12
Exon count:
32
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 12 NC_007123.7 (4114457..4143798)
105 previous assembly GRCz10 (GCF_000002035.5) 12 NC_007123.6 (4077710..4106974)

Chromosome 12 - NC_007123.7Genomic Context describing neighboring genes Neighboring gene aldolase a, fructose-bisphosphate, b Neighboring gene integrin alpha-X-like Neighboring gene integrin, alpha M (complement component 3 receptor 3 subunit), tandem duplicate 2 Neighboring gene si:dkey-32n7.7

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Effect of aerobic exercise as a treatment on type 2 diabetes mellitus with depression-like behavior zebrafish. Wang L, et al. Life Sci, 2022 Jul 1. PMID 35489565
  2. The Ameliorative Effects of Isorhynchophylline on Morphine Dependence Are Mediated Through the Microbiota-Gut-Brain Axis. Chen Z, et al. Front Pharmacol, 2021. PMID 34168553, Free PMC Article
  3. Delayed behavioral and genomic responses to acute combined stress in zebrafish, potentially relevant to PTSD and other stress-related disorders: Focus on neuroglia, neuroinflammation, apoptosis and epigenetic modulation. Yang L, et al. Behav Brain Res, 2020 Jul 1. PMID 32344037
  4. Identification of a conserved and acute neurodegeneration-specific microglial transcriptome in the zebrafish. Oosterhof N, et al. Glia, 2017 Jan. PMID 27757989, Free PMC Article
  5. Behavioral and physiological effects of acute and chronic kava exposure in adult zebrafish. Wang D, et al. Neurotoxicol Teratol, 2020 May-Jun. PMID 32240749

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables integrin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within cell adhesion IEA
Inferred from Electronic Annotation
more info
  
involved_in cell adhesion mediated by integrin IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cell-cell adhesion IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cell-matrix adhesion IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in integrin-mediated signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within integrin-mediated signaling pathway IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in external side of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of integrin complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of integrin complex IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
integrin alpha-M-like

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007123.7 Reference GRCz11 Primary Assembly

    Range
    4114457..4143798
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_009306407.3 → XP_009304682.1  integrin alpha-M-like

    See identical proteins and their annotated locations for XP_009304682.1

    UniProtKB/TrEMBL
    A0A8M3BDZ4, F1QSJ9, X1WH45
    Conserved Domains (3) summary
    smart00191
    Location:520 → 572
    Int_alpha; Integrin alpha (beta-propellor repeats)
    pfam08441
    Location:616 → 908
    Integrin_alpha2; Integrin alpha
    cl00057
    Location:158 → 331
    vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...

  2. XM_009306408.3 → XP_009304683.1  integrin alpha-M-like

    See identical proteins and their annotated locations for XP_009304683.1

    UniProtKB/TrEMBL
    A0A8M3BDZ4, F1QSJ9, X1WH45
    Conserved Domains (3) summary
    smart00191
    Location:520 → 572
    Int_alpha; Integrin alpha (beta-propellor repeats)
    pfam08441
    Location:616 → 908
    Integrin_alpha2; Integrin alpha
    cl00057
    Location:158 → 331
    vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...

  3. XM_005156007.4 → XP_005156064.1  integrin alpha-M-like

    See identical proteins and their annotated locations for XP_005156064.1

    UniProtKB/TrEMBL
    A0A8M3BDZ4, F1QSJ9, X1WH45
    Related
    ENSDARP00000014655.7, ENSDART00000025912.9
    Conserved Domains (3) summary
    smart00191
    Location:520 → 572
    Int_alpha; Integrin alpha (beta-propellor repeats)
    pfam08441
    Location:616 → 908
    Integrin_alpha2; Integrin alpha
    cl00057
    Location:158 → 331
    vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...

  4. XM_009306409.3 → XP_009304684.1  integrin alpha-M-like

    See identical proteins and their annotated locations for XP_009304684.1

    UniProtKB/TrEMBL
    A0A8M3BDZ4, F1QSJ9, X1WH45
    Related
    ENSDARP00000129555.2, ENSDART00000153699.4
    Conserved Domains (3) summary
    smart00191
    Location:520 → 572
    Int_alpha; Integrin alpha (beta-propellor repeats)
    pfam08441
    Location:616 → 908
    Integrin_alpha2; Integrin alpha
    cl00057
    Location:158 → 331
    vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...
Nucleotide Protein
Heading Accession and Version

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