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HCK HCK proto-oncogene, Src family tyrosine kinase [ Macaca fascicularis (crab-eating macaque) ]

Gene ID: 102115729, updated on 11-Apr-2024

Summary

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Gene symbol
HCK
Gene description
HCK proto-oncogene, Src family tyrosine kinase
See related
Ensembl:ENSMFAG00000035912
Gene type
protein coding
RefSeq status
MODEL
Organism
Macaca fascicularis
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
Also known as
p56-HCK
Orthologs
human mouse all
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Genomic context

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See HCK in Genome Data Viewer
Location:
chromosome: 10
Exon count:
13
Annotation release Status Assembly Chr Location
102 current MFA1912RKSv2 (GCF_012559485.2) 10 NC_052264.1 (28237185..28286979)
101 previous assembly Macaca_fascicularis_5.0 (GCF_000364345.1) 10 NC_022281.1 (63380354..63430432)

Chromosome 10 - NC_052264.1Genomic Context describing neighboring genes Neighboring gene XK related 7 Neighboring gene uncharacterized LOC107131098 Neighboring gene CCM2 like scaffold protein Neighboring gene transmembrane 9 superfamily member 4 Neighboring gene probable ribosome biogenesis protein RLP24

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Interaction with simian Hck tyrosine kinase reveals convergent evolution of the Nef protein from simian and human immunodeficiency viruses despite differential molecular surface usage. Picard C, et al. Virology, 2002 Apr 10. PMID 12033791

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables non-membrane spanning protein tyrosine kinase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables signaling receptor binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in cell differentiation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in cell surface receptor protein tyrosine kinase signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in innate immune response IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in extrinsic component of cytoplasmic side of plasma membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
tyrosine-protein kinase HCK
Names
Hematopoietic cell kinase
Tyrosine-protein kinase HCK
hemopoietic cell kinase
XP_005568712.1

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Macaca fascicularis Annotation Release 102 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference MFA1912RKSv2 Primary Assembly

Genomic

  1. NC_052264.1 Reference MFA1912RKSv2 Primary Assembly

    Range
    28237185..28286979
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005568655.3 → XP_005568712.1  tyrosine-protein kinase HCK

    See identical proteins and their annotated locations for XP_005568712.1

    UniProtKB/Swiss-Prot
    Q95M30
    Related
    ENSMFAP00000022053.1
    Conserved Domains (3) summary
    cd10363
    Location:118 → 221
    SH2_Src_HCK; Src homology 2 (SH2) domain found in HCK
    cl17036
    Location:60 → 115
    SH3; Src Homology 3 domain superfamily
    cl21453
    Location:232 → 502
    PKc_like; Protein Kinases, catalytic domain

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001319443.1: Suppressed sequence

    Description
    NM_001319443.1: This RefSeq record was removed as a result of standard genome annotation processing. Contact info@ncbi.nlm.nih.gov for further information.
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q95M30.3 GenPept UniProtKB/Swiss-Prot:Q95M30

Gene LinkOut

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