PCBP2-OT1 PCBP2 overlapping transcript 1 [Homo sapiens (human)] - Gene

Summary

Official Symbol: PCBP2-OT1provided by HGNC
Official Full Name: PCBP2 overlapping transcript 1provided by HGNC
Primary source: HGNC:HGNC:49150
See related: Ensembl:ENSG00000282977 AllianceGenome:HGNC:49150
Gene type: ncRNA
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: TUC338; uc.338; TUC.338
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Genomic context

Location:: 12q13.13

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	12	NC_000012.12 (53464468..53465057)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	12	NC_060936.1 (53430498..53431087)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	12	NC_000012.11 (53858252..53858841)

Chromosome 12 - NC_000012.12 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

lncRNA TUC338 is a potential diagnostic biomarker for bladder cancer.
Title: lncRNA TUC338 is a potential diagnostic biomarker for bladder cancer.
After interfering and overexpressing TUC338, it was found that the activity of lung cancer cells was decreased, as well as the invasion ability after interference with TUC338.
Title: LncRNA TUC338 promotes invasion of lung cancer by activating MAPK pathway.
Results found that TUC338 was upregulated in tumor tissues of prostate carcinoma patients as well as its plasma levels which correlates with poor survival. Further results provide evidence that TUC338 may serve as an oncogene in prostate carcinoma patients by downregulating miR-466.
Title: LncRNA TUC338 is overexpressed in prostate carcinoma and downregulates miR-466.
Our results show that uc.338 may play an important role in tumorigenesis and progression and could serve as a potential independent prognostic biomarker for patients with non-small cell lung cancer
Title: Up-regulation of long noncoding RNA uc.338 predicts poor survival in non-small cell lung cancer.
TUC.338 is up-regulated in colorectal cancer tissues and cell lines, and it is associated with lymphatic metastasis.TIMP-1 is negatively regulated by TUC.338 at the posttranscriptional level, via a specific target site within the 3' UTR. TUC.338 acts as a novel oncogene by targeting the TIMP-1 gene thus promoting colorectal cancer cell migration and invasion.
Title: TUC.338 promotes invasion and metastasis in colorectal cancer.
overexpression leads to enhanced proliferation and reduced apoptosis in tongue squamous cell carcinoma
Title: TUC338 Overexpression Leads to Enhanced Proliferation and Reduced Apoptosis in Tongue Squamous Cell Carcinoma Cells In Vitro.
TUC338 role in in sorafenib-resistance of liver cancer cells
Title: Long non-coding RNA TUC338 is functionally involved in sorafenib-sensitized hepatocarcinoma cells by targeting RASAL1.

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Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Other Names

PCBP2 overlapping transcript 1 (non-protein coding)
transcribed ultra-conserved region 338

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.