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MFSD10 major facilitator superfamily domain containing 10 [ Homo sapiens (human) ]

Gene ID: 10227, updated on 3-Apr-2024

Summary

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Official Symbol
MFSD10provided by HGNC
Official Full Name
major facilitator superfamily domain containing 10provided by HGNC
Primary source
HGNC:HGNC:16894
See related
Ensembl:ENSG00000109736 MIM:610977; AllianceGenome:HGNC:16894
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TETRAN; TETTRAN
Summary
This gene encodes a member of the major facilitator superfamily of transporter proteins. The encoded protein likely functions in efflux of organic anions, including the non-steroidal anti-inflammatory drugs indomethacin and diclofenac. Alternatively spliced transcript variants have been described. [provided by RefSeq, Mar 2009]
Expression
Ubiquitous expression in bone marrow (RPKM 36.8), spleen (RPKM 13.5) and 24 other tissues See more
Orthologs
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Genomic context

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Location:
4p16.3
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 4 NC_000004.12 (2930567..2934825, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 4 NC_060928.1 (2929030..2933288, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (2932294..2936552, complement)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15182 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21188 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21189 Neighboring gene nonconserved acetylation island sequence 125 enhancer Neighboring gene SH3 domain binding protein 2 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21191 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15183 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15184 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15185 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15186 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:2821815-2822316 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:2827676-2828562 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:2828563-2829448 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21192 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21193 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:2838931-2839928 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21194 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr4:2844343-2844854 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15187 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15188 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15189 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15190 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21195 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21196 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15191 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21197 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:2863877-2864589 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr4:2864590-2865301 Neighboring gene adducin 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:2876343-2876870 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:2876871-2877396 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21198 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:2923771-2924668 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:2924669-2925564 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:2925565-2926460 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:2927877-2928392 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21199 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21200 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21201 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21202 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:2935265-2936132 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15193 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15194 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr4:2937390-2938589 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21204 Neighboring gene NOP14 antisense RNA 1 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr4:2948362-2949561 Neighboring gene NOP14 nucleolar protein Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21205 Neighboring gene H3K27ac hESC enhancer GRCh37_chr4:2964791-2965324 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:2965325-2965858 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15196 Neighboring gene G protein-coupled receptor kinase 4 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr4:3011160-3012359 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21206 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:3022951-3023451 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21208 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21209 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21210 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21211

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. A gene from chromosome 4p16.3 with similarity to a superfamily of transporter proteins. Duyao MP, et al. Hum Mol Genet, 1993 Jun. PMID 8353488
  2. Expression and function of TETRAN, a new type of membrane transporter. Ushijima H, et al. Biochem Biophys Res Commun, 2008 Sep 19. PMID 18638446
  3. Identification of the TPO1 gene in yeast, and its human orthologue TETRAN, which cause resistance to NSAIDs. Mima S, et al. FEBS Lett, 2007 Apr 3. PMID 17362938
  4. Phosphodiesterase 2A2 regulates mitochondria clearance through Parkin-dependent mitophagy. Lobo MJ, et al. Commun Biol, 2020 Oct 21. PMID 33087821, Free PMC Article
  5. Interactome Analysis of Human Phospholipase D and Phosphatidic Acid-Associated Protein Network. Kattan RE, et al. Mol Cell Proteomics, 2022 Feb. PMID 35007762, Free PMC Article

See all (23) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables organic anion transmembrane transporter activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables tetracycline transmembrane transporter activity TAS
Traceable Author Statement
more info
 PubMed 
Process Evidence Code Pubs
involved_in apoptotic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within sodium-independent organic anion transport IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in tetracycline transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in brush border membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasmic vesicle membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane TAS
Traceable Author Statement
more info
 PubMed 
located_in nuclear inner membrane ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
major facilitator superfamily domain-containing protein 10
Names
tetracycline transporter-like protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001120.5 → NP_001111.3  major facilitator superfamily domain-containing protein 10 isoform a

    See identical proteins and their annotated locations for NP_001111.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. Both variants 1 and 2 encode the same isoform (a).
    Source sequence(s)
    AL390065, BC001502, BC023537, BI769550, L11669
    Consensus CDS
    CCDS3365.1
    UniProtKB/Swiss-Prot
    Q07706, Q14728
    Related
    ENSP00000332646.4, ENST00000329687.8
    Conserved Domains (1) summary
    pfam07690
    Location:85 → 412
    MFS_1; Major Facilitator Superfamily

  2. NM_001146069.2 → NP_001139541.1  major facilitator superfamily domain-containing protein 10 isoform a

    See identical proteins and their annotated locations for NP_001139541.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same isoform (a).
    Source sequence(s)
    BC001502, CN422014
    Consensus CDS
    CCDS3365.1
    UniProtKB/Swiss-Prot
    Q07706, Q14728
    Related
    ENSP00000347619.4, ENST00000355443.9
    Conserved Domains (1) summary
    pfam07690
    Location:85 → 412
    MFS_1; Major Facilitator Superfamily

  3. NM_001363679.2 → NP_001350608.1  major facilitator superfamily domain-containing protein 10 isoform b

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and lacks an alternate exon compared to variant 1, that causes a frameshift. The resulting isoform (b) has a shorter and distinct C-terminus compared to isoform a.
    Source sequence(s)
    AL390065
    Consensus CDS
    CCDS87203.1
    UniProtKB/TrEMBL
    D6RA47, D6RIZ4
    Related
    ENSP00000423402.1, ENST00000507555.1
    Conserved Domains (1) summary
    cl21472
    Location:90 → 225
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...

  4. NM_001410703.1 → NP_001397632.1  major facilitator superfamily domain-containing protein 10 isoform c

    Status: REVIEWED

    Source sequence(s)
    AL390065
    Consensus CDS
    CCDS93471.1
    UniProtKB/TrEMBL
    D6RE79
    Related
    ENSP00000426907.1, ENST00000514800.5

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p14 Primary Assembly

    Range
    2930567..2934825 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047449490.1 → XP_047305446.1  major facilitator superfamily domain-containing protein 10 isoform X1

    UniProtKB/TrEMBL
    D6RA47

  2. XM_047449491.1 → XP_047305447.1  major facilitator superfamily domain-containing protein 10 isoform X2

    UniProtKB/TrEMBL
    D6R9N3
    Related
    ENSP00000423509.1, ENST00000503596.5

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060928.1 Alternate T2T-CHM13v2.0

    Range
    2929030..2933288 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054348717.1 → XP_054204692.1  major facilitator superfamily domain-containing protein 10 isoform X1

    UniProtKB/TrEMBL
    D6RA47

  2. XM_054348718.1 → XP_054204693.1  major facilitator superfamily domain-containing protein 10 isoform X3

  3. XM_054348719.1 → XP_054204694.1  major facilitator superfamily domain-containing protein 10 isoform X2

    UniProtKB/TrEMBL
    D6R9N3
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q14728.1 GenPept UniProtKB/Swiss-Prot:Q14728

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