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Lars2 leucyl-tRNA synthetase, mitochondrial [ Mus musculus (house mouse) ]

Gene ID: 102436, updated on 25-Jan-2022

Summary

Official Symbol
Lars2provided by MGI
Official Full Name
leucyl-tRNA synthetase, mitochondrialprovided by MGI
Primary source
MGI:MGI:2142973
See related
Ensembl:ENSMUSG00000035202 AllianceGenome:MGI:2142973
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
LEURS; AI035546; Kiaa0028
Summary
Predicted to enable leucine-tRNA ligase activity. Predicted to be involved in leucyl-tRNA aminoacylation and mitochondrial translation. Predicted to act upstream of or within translation. Located in mitochondrion. Is expressed in pancreas epithelium. Human ortholog(s) of this gene implicated in Perrault syndrome. Orthologous to human LARS2 (leucyl-tRNA synthetase 2, mitochondrial). [provided by Alliance of Genome Resources, Nov 2021]
Expression
Ubiquitous expression in cortex adult (RPKM 1105.1), placenta adult (RPKM 827.6) and 25 other tissues See more
Orthologs
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Genomic context

See Lars2 in Genome Data Viewer
Location:
9 F4; 9 73.92 cM
Exon count:
22
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (123195992..123291740)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (123366927..123462675)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 9 NC_000075.5 (123276058..123371782)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene transmembrane protein 158 Neighboring gene sterol carrier protein 2, pseudogene 2 Neighboring gene predicted gene, 46137 Neighboring gene predicted gene, 40586 Neighboring gene LIM domains containing 1

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables aminoacyl-tRNA editing activity IEA
Inferred from Electronic Annotation
more info
 
enables aminoacyl-tRNA ligase activity IEA
Inferred from Electronic Annotation
more info
 
enables leucine-tRNA ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables leucine-tRNA ligase activity ISO
Inferred from Sequence Orthology
more info
 
enables ligase activity IEA
Inferred from Electronic Annotation
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in leucyl-tRNA aminoacylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in leucyl-tRNA aminoacylation ISO
Inferred from Sequence Orthology
more info
 
involved_in mitochondrial translation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in tRNA aminoacylation for protein translation IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within translation IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in mitochondrion HDA PubMed 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
probable leucine--tRNA ligase, mitochondrial
NP_001335096.1
NP_001335097.1
NP_694808.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001348167.1NP_001335096.1  probable leucine--tRNA ligase, mitochondrial isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate splice site in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same isoform (1).
    Source sequence(s)
    AC164123, BC080303, BY630405
    Consensus CDS
    CCDS23659.1
    UniProtKB/Swiss-Prot
    Q8VDC0
    Conserved Domains (1) summary
    cl26128
    Location:56900
    tRNA-synt_1g; tRNA synthetases class I (M)
  2. NM_001348168.1NP_001335097.1  probable leucine--tRNA ligase, mitochondrial isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, has multiple coding region differences, and initiates translation at an alternate start site compared to variant 1. It encodes isoform 2 which has a shorter N-terminus compared to isoform 1.
    Source sequence(s)
    AC125254, BC080303, BY282131, BY630405
    UniProtKB/Swiss-Prot
    Q8VDC0
    Conserved Domains (1) summary
    cl26128
    Location:5652
    tRNA-synt_1g; tRNA synthetases class I (M)
  3. NM_153168.3NP_694808.1  probable leucine--tRNA ligase, mitochondrial isoform 1

    See identical proteins and their annotated locations for NP_694808.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1). Both variants 1 and 2 encode the same isoform (1).
    Source sequence(s)
    BC080303, BY282131, BY630405
    Consensus CDS
    CCDS23659.1
    UniProtKB/Swiss-Prot
    Q8VDC0
    Related
    ENSMUSP00000036710.8, ENSMUST00000038863.9
    Conserved Domains (1) summary
    cl26128
    Location:56900
    tRNA-synt_1g; tRNA synthetases class I (M)

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    123195992..123291740
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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