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GLYAT glycine-N-acyltransferase [ Homo sapiens (human) ]

Gene ID: 10249, updated on 11-Sep-2019

Summary

Official Symbol
GLYATprovided by HGNC
Official Full Name
glycine-N-acyltransferaseprovided by HGNC
Primary source
HGNC:HGNC:13734
See related
Ensembl:ENSG00000149124 MIM:607424
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CAT; GAT; ACGNAT
Summary
The glycine-N-acyltransferase protein conjugates glycine with acyl-CoA substrates in the mitochondria. The protein is thought to be important in the detoxification of endogenous and xenobiotic acyl-CoA's. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Expression
Biased expression in kidney (RPKM 86.1), liver (RPKM 53.7) and 1 other tissue See more
Orthologs

Genomic context

See GLYAT in Genome Data Viewer
Location:
11q12.1
Exon count:
7
Annotation release Status Assembly Chr Location
109.20190905 current GRCh38.p13 (GCF_000001405.39) 11 NC_000011.10 (58708757..58731974, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (58476230..58499447, complement)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene ZFP91-CNTF readthrough (NMD candidate) Neighboring gene ZFP91 zinc finger protein Neighboring gene ciliary neurotrophic factor Neighboring gene glycine-N-acyltransferase pseudogene Neighboring gene Sharpr-MPRA regulatory region 12556

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Suggestion of GLYAT gene underlying variation of bone size and body lean mass as revealed by a bivariate genome-wide association study.
NHGRI GWA Catalog

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
glycine N-acyltransferase activity IDA
Inferred from Direct Assay
more info
PubMed 
glycine N-benzoyltransferase activity IDA
Inferred from Direct Assay
more info
PubMed 
glycine N-benzoyltransferase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
transferase activity, transferring acyl groups TAS
Traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
acyl-CoA metabolic process TAS
Traceable Author Statement
more info
PubMed 
benzoyl-CoA metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
glycine metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
glycine metabolic process ISS
Inferred from Sequence or Structural Similarity
more info
 
monocarboxylic acid metabolic process ISS
Inferred from Sequence or Structural Similarity
more info
 
response to toxic substance IEA
Inferred from Electronic Annotation
more info
 
xenobiotic metabolic process TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
mitochondrial matrix TAS
Traceable Author Statement
more info
 
mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 
mitochondrion ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
glycine N-acyltransferase
Names
AAc
HRP-1(CLP)
acyl-CoA:glycine N-acyltransferase
aralkyl acyl-CoA N-acyltransferase
aralkyl acyl-CoA:amino acid N-acyltransferase
aralkyl-CoA N-acyltransferase
benzoyl-coenzyme A:glycine N-acyltransferase
epididymis secretory sperm binding protein
glycine N-benzoyltransferase
NP_005829.3
NP_964011.2
XP_016872576.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_005838.3NP_005829.3  glycine N-acyltransferase isoform b

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 3' coding region and 3' UTR compared to variant 1. The resulting isoform (b) is shorter and has a distinct C-terminus compared to isoform a.
    Source sequence(s)
    AF023466, BC009785, BP277146, DR004166
    Consensus CDS
    CCDS7971.1
    UniProtKB/Swiss-Prot
    Q6IB77
    Related
    ENSP00000278400.3, ENST00000278400.3
    Conserved Domains (1) summary
    pfam06021
    Location:11161
    Gly_acyl_tr_N; Aralkyl acyl-CoA:amino acid N-acyltransferase
  2. NM_201648.3NP_964011.2  glycine N-acyltransferase isoform a

    See identical proteins and their annotated locations for NP_964011.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a).
    Source sequence(s)
    AI253073, AP000445, BC009785, BG617408, CB161978
    Consensus CDS
    CCDS7970.1
    UniProtKB/Swiss-Prot
    Q6IB77
    Related
    ENSP00000340200.3, ENST00000344743.8
    Conserved Domains (2) summary
    pfam08444
    Location:207295
    Gly_acyl_tr_C; Aralkyl acyl-CoA:amino acid N-acyltransferase, C-terminal region
    pfam06021
    Location:11206
    Gly_acyl_tr_N; Aralkyl acyl-CoA:amino acid N-acyltransferase

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p13 Primary Assembly

    Range
    58708757..58731974 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017017087.1XP_016872576.1  glycine N-acyltransferase isoform X1

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