Pls1 plastin 1 (I-isoform) [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Pls1provided by MGI
Official Full Name: plastin 1 (I-isoform)provided by MGI
Primary source: MGI:MGI:104809
See related: Ensembl:ENSMUSG00000049493 AllianceGenome:MGI:104809
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary: Predicted to enable actin filament binding activity. Involved in several processes, including inner ear receptor cell stereocilium organization; intestinal D-glucose absorption; and positive regulation of protein localization to plasma membrane. Acts upstream of or within terminal web assembly. Located in brush border; stereocilium; and terminal web. Is expressed in egg cylinder; female reproductive system; and gut. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness 76. Orthologous to human PLS1 (plastin 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in large intestine adult (RPKM 58.4), small intestine adult (RPKM 19.6) and 4 other tissues See more
Orthologs: human all
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Genomic context

Location:: 9 E3.3; 9 50.22 cM

Exon count:: 17

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	9	NC_000075.7 (95634695..95727359, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	9	NC_000075.6 (95752642..95845306, complement)

Chromosome 9 - NC_000075.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

we have identified a role for L-plastin in stabilizing long-lived podosomes and in enabling macrophage motility
Title: L-Plastin promotes podosome longevity and supports macrophage motility.
PLS1 biases actin toward liquid packing, which allows stereocilia to grow to a greater diameter.
Title: Plastin 1 widens stereocilia by transforming actin filament packing from hexagonal to liquid.
Results show that plastin 1 is dispensable for the initial formation of stereocilia.
Title: Absence of plastin 1 causes abnormal maintenance of hair cell stereocilia and a moderate form of hearing loss in mice.
This study identified LPL as being key to alveolar macrophage development and essential to an effective antipneumococcal response.
Title: L-plastin is essential for alveolar macrophage production and control of pulmonary pneumococcal infection.
Plastin 1 accumulates in the terminal web and interacts with keratin 19, possibly contributing to anchoring the rootlets to the keratin network.
Title: Plastin 1 binds to keratin and is required for terminal web assembly in the intestinal epithelium.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (1) 1 citation
Endonuclease-mediated (3)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AI427122 (e-PCR)
- UniSTS:159911

NoName (e-PCR)
- UniSTS:236222

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables actin binding	IEA Inferred from Electronic Annotation more info
enables actin filament binding	IBA Inferred from Biological aspect of Ancestor more info
enables calcium ion binding	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in actin filament bundle assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in actin filament network formation	IBA Inferred from Biological aspect of Ancestor more info
involved_in auditory receptor cell stereocilium organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in intestinal D-glucose absorption	IGI Inferred from Genetic Interaction more info	PubMed
NOT involved_in microvillus assembly	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of multicellular organism growth	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of protein localization to plasma membrane	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of protein localization to plasma membrane	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of microvillus length	IGI Inferred from Genetic Interaction more info	PubMed
involved_in terminal web assembly	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within terminal web assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in vestibular receptor cell stereocilium organization	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in actin filament	IBA Inferred from Biological aspect of Ancestor more info
is_active_in actin filament bundle	IBA Inferred from Biological aspect of Ancestor more info
located_in brush border	IDA Inferred from Direct Assay more info	PubMed
located_in cell projection	IEA Inferred from Electronic Annotation more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in cytosol	TAS Traceable Author Statement more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in stereocilium	IDA Inferred from Direct Assay more info	PubMed
located_in terminal web	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: plastin-1

Names: I-fimbrin; plastin 1, I

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001033210.3 → NP_001028382.1 plastin-1

See identical proteins and their annotated locations for NP_001028382.1

Status: VALIDATED

Source sequence(s)

AI526519, AK030875, AK133070, AW124763, CJ229558

Consensus CDS

CCDS23412.1

UniProtKB/Swiss-Prot

Q3V0K9

Related

ENSMUSP00000091317.3, ENSMUST00000093800.9

Conserved Domains (1) summary

COG5069
Location:13 → 622

SAC6; Ca2+-binding actin-bundling protein fimbrin/plastin (EF-Hand superfamily) [Cytoskeleton]

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000075.7 Reference GRCm39 C57BL/6J

Range

95634695..95727359 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006510748.1 → XP_006510811.1 plastin-1 isoform X2

Conserved Domains (1) summary

COG5069
Location:27 → 543

SAC6; Ca2+-binding actin-bundling protein fimbrin/plastin (EF-Hand superfamily) [Cytoskeleton]
XM_006510746.4 → XP_006510809.1 plastin-1 isoform X1

See identical proteins and their annotated locations for XP_006510809.1

UniProtKB/Swiss-Prot

Q3V0K9

Conserved Domains (1) summary

COG5069
Location:13 → 622

SAC6; Ca2+-binding actin-bundling protein fimbrin/plastin (EF-Hand superfamily) [Cytoskeleton]