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TP53 tumor protein p53 [ Tupaia chinensis (Chinese tree shrew) ]

Gene ID: 102503238, updated on 10-Mar-2024

Summary

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Gene symbol
TP53
Gene description
tumor protein p53
Locus tag
TREES_T100004110
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Tupaia chinensis
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Scandentia; Tupaiidae; Tupaia
Also known as
p53
Annotation information
Annotation category: partial on reference assembly
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: Un
Exon count:
8
Annotation release Status Assembly Chr Location
102 current TupChi_1.0 (GCF_000334495.1) Unplaced Scaffold NW_006159824.1 (859691..866641)

NW_006159824.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102502250 Neighboring gene WD repeat containing antisense to TP53 Neighboring gene ATPase Na+/K+ transporting subunit beta 2 Neighboring gene sex hormone binding globulin

Genomic regions, transcripts, and products

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Genomic Sequence:
NW_006159824 Unplaced Scaffold Reference TupChi_1.0

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The tetramerization domain of the tree shrew p53 protein displays unique thermostability despite sharing high sequence identity with the human p53 protein. Nakagawa N, et al. Biochem Biophys Res Commun, 2020 Jan 15. PMID 31690451
  2. Mutations in the p53 tumor suppressor gene in tree shrew hepatocellular carcinoma associated with hepatitis B virus infection and intake of aflatoxin B1. Park US, et al. Gene, 2000 Jun 13. PMID 10863098

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The thermostability of tree shrew p53 tetramerization domain is much higher than human p53.
    Title: The tetramerization domain of the tree shrew p53 protein displays unique thermostability despite sharing high sequence identity with the human p53 protein.
Submit: New GeneRIF Correction

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables protein binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in apoptotic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in protein tetramerization IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
cellular tumor antigen p53
Names
p53 tumor suppressor protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001287369.1 → NP_001274298.1  cellular tumor antigen p53

    See identical proteins and their annotated locations for NP_001274298.1

    Status: PROVISIONAL

    Source sequence(s)
    AF175893
    Conserved Domains (3) summary
    pfam00870
    Location:95 → 289
    P53; P53 DNA-binding domain
    pfam07710
    Location:319 → 358
    P53_tetramer; P53 tetramerization motif
    pfam08563
    Location:5 → 28
    P53_TAD; P53 transactivation motif

RefSeqs of Annotated Genomes: Tupaia chinensis Annotation Release 102 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference TupChi_1.0

Genomic

  1. NW_006159824.1 Reference TupChi_1.0

    Range
    859691..866641
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

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