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Alg9 ALG9 alpha-1,2-mannosyltransferase [ Mus musculus (house mouse) ]

Gene ID: 102580, updated on 5-Mar-2024

Summary

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Official Symbol
Alg9provided by MGI
Official Full Name
ALG9 alpha-1,2-mannosyltransferaseprovided by MGI
Primary source
MGI:MGI:1924753
See related
Ensembl:ENSMUSG00000032059 AllianceGenome:MGI:1924753
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Dibd1; 8230402H15Rik; B430313H07Rik
Summary
Predicted to enable alpha-1,2-mannosyltransferase activity. Predicted to be involved in protein N-linked glycosylation. Predicted to be located in endoplasmic reticulum and membrane. Predicted to be integral component of membrane. Predicted to be active in endoplasmic reticulum membrane. Human ortholog(s) of this gene implicated in congenital disorder of glycosylation Il. Orthologous to human ALG9 (ALG9 alpha-1,2-mannosyltransferase). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in testis adult (RPKM 8.7), CNS E18 (RPKM 8.6) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Alg9 in Genome Data Viewer
Location:
9 A5.3; 9 27.75 cM
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (50686570..50754939)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (50775225..50843639)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E3828 Neighboring gene STARR-positive B cell enhancer ABC_E9760 Neighboring gene cilia and flagella associated protein 68 Neighboring gene ferredoxin-fold anticodon binding domain containing 1 Neighboring gene predicted gene, 57547 Neighboring gene STARR-seq mESC enhancer starr_24122 Neighboring gene STARR-positive B cell enhancer mm9_chr9:50664895-50665195 Neighboring gene protein phosphatase 2, regulatory subunit A, beta Neighboring gene predicted gene, 25558 Neighboring gene salt inducible kinase 2 Neighboring gene STARR-seq mESC enhancer starr_24123 Neighboring gene STARR-seq mESC enhancer starr_24124 Neighboring gene STARR-positive B cell enhancer ABC_E8290

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Viral Infection-Induced Differential Expression of LncRNAs Associated with Collagen in Mouse Placentas and Amniotic Sacs. Pan J, et al. Am J Reprod Immunol, 2015 Sep. PMID 26073538
  2. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199
  3. Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray. Tanaka TS, et al. Proc Natl Acad Sci U S A, 2000 Aug 1. PMID 10922068, Free PMC Article
  4. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
  5. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables alpha-1,2-mannosyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables dol-P-Man:Man(6)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables dol-P-Man:Man(8)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables glycosyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in protein N-linked glycosylation IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
is_active_in endoplasmic reticulum membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
alpha-1,2-mannosyltransferase ALG9
Names
asparagine-linked glycosylation 9 (alpha 1,2 mannosyltransferase)
asparagine-linked glycosylation 9 homolog (yeast, alpha 1,2 mannosyltransferase)
asparagine-linked glycosylation 9 protein
asparagine-linked glycosylation protein 9 homolog
disrupted in bipolar disorder 1 homolog
disrupted in bipolar disorder protein 1 homolog
dol-P-Man:Man(6)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase
dol-P-Man:Man(8)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase
NP_598742.1
XP_006509964.1
XP_006509965.1
XP_006509966.1
XP_011240682.1
XP_017168554.1
XP_030099802.1
XP_030099803.1
XP_030099804.1
XP_030099805.1
XP_030099806.1
XP_036010400.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_133981.3 → NP_598742.1  alpha-1,2-mannosyltransferase ALG9

    See identical proteins and their annotated locations for NP_598742.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the protein-coding transcript for this locus.
    Source sequence(s)
    AC123614
    Consensus CDS
    CCDS23175.1
    UniProtKB/Swiss-Prot
    Q8BT44, Q8C378, Q8C7G0, Q8VDI9
    Related
    ENSMUSP00000034561.5, ENSMUST00000034561.11
    Conserved Domains (1) summary
    pfam03901
    Location:60 → 482
    Glyco_transf_22; Alg9-like mannosyltransferase family

RNA

  1. NR_045601.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC123614
    Related
    ENSMUST00000162073.8

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    50686570..50754939
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006509901.3 → XP_006509964.1  alpha-1,2-mannosyltransferase ALG9 isoform X1

    Conserved Domains (1) summary
    pfam03901
    Location:60 → 482
    Glyco_transf_22; Alg9-like mannosyltransferase family

  2. XM_006509902.3 → XP_006509965.1  alpha-1,2-mannosyltransferase ALG9 isoform X2

    Conserved Domains (1) summary
    pfam03901
    Location:60 → 441
    Glyco_transf_22; Alg9-like mannosyltransferase family

  3. XM_030243942.2 → XP_030099802.1  alpha-1,2-mannosyltransferase ALG9 isoform X3

    Conserved Domains (1) summary
    pfam03901
    Location:60 → 441
    Glyco_transf_22; Alg9-like mannosyltransferase family

  4. XM_030243944.2 → XP_030099804.1  alpha-1,2-mannosyltransferase ALG9 isoform X6

    Conserved Domains (1) summary
    cl21590
    Location:51 → 336
    PMT_2; Dolichyl-phosphate-mannose-protein mannosyltransferase

  5. XM_030243943.1 → XP_030099803.1  alpha-1,2-mannosyltransferase ALG9 isoform X5

    Conserved Domains (1) summary
    cl21590
    Location:51 → 377
    PMT_2; Dolichyl-phosphate-mannose-protein mannosyltransferase

  6. XM_030243945.1 → XP_030099805.1  alpha-1,2-mannosyltransferase ALG9 isoform X7

    Conserved Domains (1) summary
    cl21590
    Location:1 → 311
    PMT_2; Dolichyl-phosphate-mannose-protein mannosyltransferase

  7. XM_006509903.5 → XP_006509966.1  alpha-1,2-mannosyltransferase ALG9 isoform X4

    Conserved Domains (1) summary
    cl21590
    Location:51 → 377
    PMT_2; Dolichyl-phosphate-mannose-protein mannosyltransferase

  8. XM_030243946.1 → XP_030099806.1  alpha-1,2-mannosyltransferase ALG9 isoform X8

    Conserved Domains (1) summary
    cl21590
    Location:1 → 311
    PMT_2; Dolichyl-phosphate-mannose-protein mannosyltransferase

  9. XM_036154507.1 → XP_036010400.1  alpha-1,2-mannosyltransferase ALG9 isoform X9

    Conserved Domains (1) summary
    cl21590
    Location:1 → 270
    PMT_2; Dolichyl-phosphate-mannose-protein mannosyltransferase

  10. XM_017313065.2 → XP_017168554.1  alpha-1,2-mannosyltransferase ALG9 isoform X6

    Conserved Domains (1) summary
    cl21590
    Location:51 → 336
    PMT_2; Dolichyl-phosphate-mannose-protein mannosyltransferase

  11. XM_011242380.4 → XP_011240682.1  alpha-1,2-mannosyltransferase ALG9 isoform X10

    Conserved Domains (1) summary
    cl21590
    Location:105 → 191
    PMT_2; Dolichyl-phosphate-mannose-protein mannosyltransferase
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8VDI9.1 GenPept UniProtKB/Swiss-Prot:Q8VDI9

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