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PEG10 paternally expressed 10 [ Elephantulus edwardii (Cape elephant shrew) ]

Gene ID: 102852923, updated on 10-Mar-2024

Summary

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Gene symbol
PEG10
Gene description
paternally expressed 10
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Elephantulus edwardii
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Afrotheria; Macroscelidea; Macroscelididae; Elephantulus
Summary
This gene is thought to have been derived from the Ty3/Gypsy family of retrotransposons. It contains two overlapping open reading frames, RF1 and RF2, and expresses two proteins: a shorter, gag-like protein (with a CCHC-type zinc finger domain) from RF1; and a longer, gag/pol-like fusion protein (with an additional aspartic protease motif) from RF1/RF2 by -1 translational frameshifting (-1 FS). While -1 FS has been observed in RNA viruses and transposons in both prokaryotes and eukaryotes, this gene represents the first example of -1 FS in a eukaryotic cellular gene. This gene is highly conserved across mammalian species and retains the heptanucleotide (GGGAAAC) and pseudoknot elements required for -1 FS. It is expressed in adult and embryonic tissues (most notably in placenta) and reported to have a role in cell proliferation, differentiation, apoptosis and cancer development. Knockout mice lacking this gene showed early embryonic lethality with placental defects, indicating the importance of this gene in embryonic development. [provided by RefSeq, Oct 2014]
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: Un
Exon count:
2
Annotation release Status Assembly Chr Location
100 current EleEdw1.0 (GCF_000299155.1) Unplaced Scaffold NW_006399848.1 (9873443..9875856)

NW_006399848.1Genomic Context describing neighboring genes Neighboring gene CAS1 domain containing 1 Neighboring gene sarcoglycan epsilon Neighboring gene mucin-2-like Neighboring gene kelch-like protein 11-like

Genomic regions, transcripts, and products

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Genomic Sequence:
NW_006399848 unplaced scaffold reference EleEdw1.0

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Genetic and molecular analyses of PEG10 reveal new aspects of genomic organization, transcription and translation. Lux H, et al. PLoS One, 2010 Jan 13. PMID 20084274, Free PMC Article
  2. Mammalian gene PEG10 expresses two reading frames by high efficiency -1 frameshifting in embryonic-associated tissues. Clark MB, et al. J Biol Chem, 2007 Dec 28. PMID 17942406

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in cytosol IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
retrotransposon-derived protein PEG10

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001291360.1 → NP_001278289.1  retrotransposon-derived protein PEG10 isoform 1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) has two overlapping open reading frames (RFI and RF2). This longer isoform (1) is derived from RF1/RF2 by -1 translational frameshifting.
    Source sequence(s)
    AMGZ01143227
    Conserved Domains (2) summary
    cd00303
    Location:463 → 547
    retropepsin_like; Retropepsins; pepsin-like aspartate proteases
    pfam03732
    Location:217 → 310
    Retrotrans_gag; Retrotransposon gag protein

  2. NM_001291361.1 → NP_001278290.1  retrotransposon-derived protein PEG10 isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) has two overlapping open reading frames (RFI and RF2). This isoform (2) produced from RF1 in the absence of -1 translational frameshifting has a shorter C-terminus compared to isoform 1.
    Source sequence(s)
    AMGZ01143227
    Conserved Domains (2) summary
    pfam03732
    Location:217 → 310
    Retrotrans_gag; Retrotransposon gag protein
    cl02777
    Location:183 → 217
    chaperonin_like; chaperonin_like superfamily. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. There are 2 main chaperonin groups. The symmetry of type I ...

RefSeqs of Annotated Genomes: Elephantulus edwardii Annotation Release 100 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference EleEdw1.0

Genomic

  1. NW_006399848.1 Reference EleEdw1.0

    Range
    9873443..9875856
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006891481.1 → XP_006891543.1  retrotransposon-derived protein PEG10

    Conserved Domains (2) summary
    cd00303
    Location:346 → 430
    retropepsin_like; Retropepsins; pepsin-like aspartate proteases
    pfam03732
    Location:100 → 193
    Retrotrans_gag; Retrotransposon gag protein
Nucleotide Protein
Heading Accession and Version

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