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Cenpi centromere protein I [ Mus musculus (house mouse) ]

Gene ID: 102920, updated on 5-Mar-2024

Summary

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Official Symbol
Cenpiprovided by MGI
Official Full Name
centromere protein Iprovided by MGI
Primary source
MGI:MGI:2147897
See related
Ensembl:ENSMUSG00000031262 AllianceGenome:MGI:2147897
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
CENP-I; Fshprh1
Summary
This gene encodes a protein that may be constitutively associated with centromeres and might be involved in recruiting centromere protein A to the centromere for kinetochore assembly. A similar gene in human is involved in the response of gonadal tissues to follicle-stimulating hormone. Alternatively spliced transcript variants have been identified. [provided by RefSeq, Mar 2015]
Expression
Biased expression in liver E14 (RPKM 5.1), liver E14.5 (RPKM 4.7) and 10 other tissues See more
Orthologs
human all
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Genomic context

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See Cenpi in Genome Data Viewer
Location:
X E3; X 56.08 cM
Exon count:
23
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (133206777..133263853)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (134308084..134363104)

Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_47955 Neighboring gene TRM2 tRNA methyltransferase 2B Neighboring gene transmembrane protein 35A Neighboring gene STARR-seq mESC enhancer starr_47958 Neighboring gene STARR-seq mESC enhancer starr_47959 Neighboring gene dystrophin related protein 2 Neighboring gene TATA-box binding protein associated factor 7 like

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain. Pourhaghighi R, et al. Cell Syst, 2020 Apr 22. PMID 32325033, Free PMC Article
  2. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. Hein MY, et al. Cell, 2015 Oct 22. PMID 26496610
  3. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
  4. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC40943

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in CENP-A containing chromatin assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in biological_process ND
No biological Data available
more info
  
involved_in centromere complex assembly IEA
Inferred from Electronic Annotation
more info
  
involved_in chromosome segregation NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in mitotic sister chromatid segregation IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in chromosome IEA
Inferred from Electronic Annotation
more info
  
located_in chromosome, centromeric region IEA
Inferred from Electronic Annotation
more info
  
part_of inner kinetochore IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of inner kinetochore ISO
Inferred from Sequence Orthology
more info
  
located_in kinetochore ISO
Inferred from Sequence Orthology
more info
  
located_in nuclear body ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus NAS
Non-traceable Author Statement
more info
 PubMed 

General protein information

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Preferred Names
centromere protein I
Names
FSH primary response protein 1
follicle-stimulating hormone primary response protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001305631.1 → NP_001292560.1  centromere protein I

    See identical proteins and their annotated locations for NP_001292560.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AK043344, AK085048, AK161473
    Consensus CDS
    CCDS30393.1
    UniProtKB/Swiss-Prot
    Q8BXU9, Q8K1K4
    UniProtKB/TrEMBL
    Q3TTB0, Q3UM07
    Related
    ENSMUSP00000098809.2, ENSMUST00000101251.8
    Conserved Domains (1) summary
    pfam07778
    Location:12 → 516
    CENP-I; Mis6

  2. NM_145924.3 → NP_666036.1  centromere protein I

    See identical proteins and their annotated locations for NP_666036.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AK043344, AK085048, AK161473
    Consensus CDS
    CCDS30393.1
    UniProtKB/Swiss-Prot
    Q8BXU9, Q8K1K4
    UniProtKB/TrEMBL
    Q3TTB0, Q3UM07
    Related
    ENSMUSP00000079851.6, ENSMUST00000081064.12
    Conserved Domains (1) summary
    pfam07778
    Location:12 → 516
    CENP-I; Mis6

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000086.8 Reference GRCm39 C57BL/6J

    Range
    133206777..133263853
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006528477.3 → XP_006528540.1  centromere protein I isoform X2

    Conserved Domains (1) summary
    pfam07778
    Location:12 → 463
    CENP-I; Mis6

  2. XM_017318340.2 → XP_017173829.1  centromere protein I isoform X1

    UniProtKB/Swiss-Prot
    Q8BXU9, Q8K1K4
    UniProtKB/TrEMBL
    Q3TTB0, Q3UM07
    Conserved Domains (1) summary
    pfam07778
    Location:12 → 516
    CENP-I; Mis6
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8K1K4.1 GenPept UniProtKB/Swiss-Prot:Q8K1K4

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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