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Gstt3 glutathione S-transferase, theta 3 [ Mus musculus (house mouse) ]

Gene ID: 103140, updated on 5-Jan-2022

Summary

Official Symbol
Gstt3provided by MGI
Official Full Name
glutathione S-transferase, theta 3provided by MGI
Primary source
MGI:MGI:2143526
See related
Ensembl:ENSMUSG00000001665
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
AI118089
Summary
Enables glutathione transferase activity. Acts upstream of or within glutathione metabolic process. Predicted to be active in cytoplasm. Is expressed in several structures, including alimentary system; epidermis; metatarsal bone; olfactory epithelium; and urinary system. [provided by Alliance of Genome Resources, Nov 2021]
Expression
Broad expression in liver adult (RPKM 70.4), bladder adult (RPKM 44.4) and 16 other tissues See more
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Genomic context

See Gstt3 in Genome Data Viewer
Location:
10; 10 C1
Exon count:
6
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (75609951..75617256, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (75774117..75781422, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 10 NC_000076.5 (75236867..75244159, complement)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene cytochrome b-c1 complex subunit 7 pseudogene Neighboring gene D-dopachrome tautomerase Neighboring gene glutathione S-transferase, theta 1 Neighboring gene glutathione S-transferase, theta 4

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables glutathione transferase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables glutathione transferase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in glutathione metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within glutathione metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
glutathione S-transferase theta-3
NP_001333452.1
NP_598755.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001346523.1NP_001333452.1  glutathione S-transferase theta-3 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC142499, AK138669, BY232658, CX204823
    Consensus CDS
    CCDS88023.1
    UniProtKB/Swiss-Prot
    Q99L20
    UniProtKB/TrEMBL
    G3UX05
    Related
    ENSMUSP00000133498.2, ENSMUST00000173537.2
  2. NM_133994.3NP_598755.1  glutathione S-transferase theta-3 isoform 1

    See identical proteins and their annotated locations for NP_598755.1

    Status: VALIDATED

    Source sequence(s)
    AC142499
    Consensus CDS
    CCDS23931.1
    UniProtKB/Swiss-Prot
    Q99L20
    Related
    ENSMUSP00000001715.4, ENSMUST00000001715.10
    Conserved Domains (3) summary
    cd03183
    Location:92216
    GST_C_Theta; C-terminal, alpha helical domain of Class Theta Glutathione S-transferases
    COG0625
    Location:3217
    GstA; Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]
    cd03050
    Location:378
    GST_N_Theta; GST_N family, Class Theta subfamily; composed of eukaryotic class Theta GSTs and bacterial dichloromethane (DCM) dehalogenase. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with ...

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    75609951..75617256 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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