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Pex12 peroxisomal biogenesis factor 12 [ Mus musculus (house mouse) ]

Gene ID: 103737, updated on 11-Apr-2024

Summary

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Official Symbol
Pex12provided by MGI
Official Full Name
peroxisomal biogenesis factor 12provided by MGI
Primary source
MGI:MGI:2144177
See related
Ensembl:ENSMUSG00000018733 AllianceGenome:MGI:2144177
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Predicted to enable protein C-terminus binding activity; ubiquitin-protein transferase activity; and zinc ion binding activity. Predicted to be involved in protein import into peroxisome matrix and protein monoubiquitination. Predicted to act upstream of or within protein transport. Predicted to be located in peroxisomal membrane. Predicted to be part of peroxisomal importomer complex. Predicted to be integral component of peroxisomal membrane. Is expressed in esophagus; lung; mandible; and maxilla. Human ortholog(s) of this gene implicated in peroxisomal biogenesis disorder and peroxisome biogenesis disorder 3A. Orthologous to human PEX12 (peroxisomal biogenesis factor 12). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in testis adult (RPKM 9.3), adrenal adult (RPKM 5.0) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Pex12 in Genome Data Viewer
Location:
11 C; 11 50.3 cM
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (83182757..83189849, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (83295072..83299005, complement)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 23444 Neighboring gene schlafen 14 Neighboring gene STARR-positive B cell enhancer ABC_E1424 Neighboring gene STARR-positive B cell enhancer ABC_E8435 Neighboring gene expressed sequence AA465934 Neighboring gene expressed sequence AI450353 Neighboring gene STARR-seq mESC enhancer starr_30193 Neighboring gene small nucleolar RNA, C/D box 7 Neighboring gene adaptor-related protein complex 2, beta 1 subunit Neighboring gene STARR-seq mESC enhancer starr_30196 Neighboring gene predicted gene, 23951 Neighboring gene RAS-like, family 10, member B

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Evolution of the Schlafen genes, a gene family associated with embryonic lethality, meiotic drive, immune processes and orthopoxvirus virulence. Bustos O, et al. Gene, 2009 Nov 1. PMID 19619625, Free PMC Article
  2. Functional genomic landscape of cancer-intrinsic evasion of killing by T cells. Lawson KA, et al. Nature, 2020 Oct. PMID 32968282, Free PMC Article
  3. EUCOMM--the European conditional mouse mutagenesis program. Friedel RH, et al. Brief Funct Genomic Proteomic, 2007 Sep. PMID 17967808
  4. Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray. Tanaka TS, et al. Proc Natl Acad Sci U S A, 2000 Aug 1. PMID 10922068, Free PMC Article
  5. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables ubiquitin ligase activator activity ISO
Inferred from Sequence Orthology
more info
  
enables ubiquitin-protein transferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables zinc ion binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in cellular response to reactive oxygen species ISO
Inferred from Sequence Orthology
more info
  
involved_in peroxisome organization ISO
Inferred from Sequence Orthology
more info
  
involved_in protein import into peroxisome matrix IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein import into peroxisome matrix ISO
Inferred from Sequence Orthology
more info
  
involved_in protein import into peroxisome matrix, receptor recycling ISO
Inferred from Sequence Orthology
more info
  
involved_in protein monoubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein polyubiquitination ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within protein transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
part_of peroxisomal importomer complex IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in peroxisomal membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in peroxisomal membrane ISO
Inferred from Sequence Orthology
more info
  
located_in peroxisomal membrane ISO
Inferred from Sequence Orthology
more info
  
located_in peroxisome ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
peroxisome assembly protein 12
Names
peroxin-12

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001364762.1 → NP_001351691.1  peroxisome assembly protein 12

    Status: VALIDATED

    Source sequence(s)
    AK035552, AK041175
    Consensus CDS
    CCDS25160.1
    UniProtKB/Swiss-Prot
    Q8VC48
    UniProtKB/TrEMBL
    Q3TLN1, Q5SWQ8
    Related
    ENSMUSP00000103781.2, ENSMUST00000108146.8
    Conserved Domains (2) summary
    cd16451
    Location:304 → 345
    mRING_PEX12; Modified RING finger found in peroxin-12 (PEX12) and similar proteins
    pfam04757
    Location:26 → 267
    Pex2_Pex12; Pex2 / Pex12 amino terminal region

  2. NM_001364763.1 → NP_001351692.1  peroxisome assembly protein 12

    Status: VALIDATED

    Source sequence(s)
    AL603711
    Consensus CDS
    CCDS25160.1
    UniProtKB/Swiss-Prot
    Q8VC48
    UniProtKB/TrEMBL
    Q3TLN1, Q5SWQ8
    Related
    ENSMUSP00000135145.2, ENSMUST00000175741.8
    Conserved Domains (2) summary
    cd16451
    Location:304 → 345
    mRING_PEX12; Modified RING finger found in peroxin-12 (PEX12) and similar proteins
    pfam04757
    Location:26 → 267
    Pex2_Pex12; Pex2 / Pex12 amino terminal region

  3. NM_134025.4 → NP_598786.1  peroxisome assembly protein 12

    See identical proteins and their annotated locations for NP_598786.1

    Status: VALIDATED

    Source sequence(s)
    AK035552
    Consensus CDS
    CCDS25160.1
    UniProtKB/Swiss-Prot
    Q8VC48
    UniProtKB/TrEMBL
    Q3TLN1, Q5SWQ8
    Related
    ENSMUSP00000018877.3, ENSMUST00000018877.9
    Conserved Domains (2) summary
    cd16451
    Location:304 → 345
    mRING_PEX12; Modified RING finger found in peroxin-12 (PEX12) and similar proteins
    pfam04757
    Location:26 → 267
    Pex2_Pex12; Pex2 / Pex12 amino terminal region

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    83182757..83189849 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030245454.2 → XP_030101314.1  peroxisome assembly protein 12 isoform X1

    UniProtKB/Swiss-Prot
    Q8VC48
    UniProtKB/TrEMBL
    Q3TLN1, Q5SWQ8
    Conserved Domains (2) summary
    cd16451
    Location:304 → 345
    mRING_PEX12; Modified RING finger found in peroxin-12 (PEX12) and similar proteins
    pfam04757
    Location:26 → 267
    Pex2_Pex12; Pex2 / Pex12 amino terminal region

  2. XM_030245453.2 → XP_030101313.1  peroxisome assembly protein 12 isoform X1

    UniProtKB/Swiss-Prot
    Q8VC48
    UniProtKB/TrEMBL
    Q3TLN1, Q5SWQ8
    Conserved Domains (2) summary
    cd16451
    Location:304 → 345
    mRING_PEX12; Modified RING finger found in peroxin-12 (PEX12) and similar proteins
    pfam04757
    Location:26 → 267
    Pex2_Pex12; Pex2 / Pex12 amino terminal region

  3. XM_030245452.2 → XP_030101312.1  peroxisome assembly protein 12 isoform X1

    UniProtKB/Swiss-Prot
    Q8VC48
    UniProtKB/TrEMBL
    Q3TLN1, Q5SWQ8
    Conserved Domains (2) summary
    cd16451
    Location:304 → 345
    mRING_PEX12; Modified RING finger found in peroxin-12 (PEX12) and similar proteins
    pfam04757
    Location:26 → 267
    Pex2_Pex12; Pex2 / Pex12 amino terminal region
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8VC48.1 GenPept UniProtKB/Swiss-Prot:Q8VC48

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