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Actn4 actinin alpha 4 [ Nannospalax galili (Upper Galilee mountains blind mole rat) ]

Gene ID: 103750716, updated on 11-Mar-2024

Summary

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Gene symbol
Actn4
Gene description
actinin alpha 4
See related
Ensembl:ENSNGAG00000023185
Gene type
protein coding
RefSeq status
MODEL
Organism
Nannospalax galili
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Spalacidae; Spalacinae; Nannospalax
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: Un
Exon count:
23
Annotation release Status Assembly Chr Location
102 current S.galili_v1.0 (GCF_000622305.1) Unplaced Scaffold NW_008355971.1 (1655473..1724995)

NW_008355971.1Genomic Context describing neighboring genes Neighboring gene mitogen-activated protein kinase kinase kinase kinase 1 Neighboring gene small nucleolar RNA SNORA9 Neighboring gene eukaryotic translation initiation factor 3 subunit K Neighboring gene uncharacterized LOC115067786 Neighboring gene uncharacterized LOC115067787 Neighboring gene calpain 12

Genomic regions, transcripts, and products

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Genomic Sequence:
NW_008355971 Unplaced Scaffold Reference S.galili_v1.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Transcriptome sequencing of the blind subterranean mole rat, Spalax galili: utility and potential for the discovery of novel evolutionary patterns. Malik A, et al. PLoS One, 2011. PMID 21857902, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables actin filament binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in actin cytoskeleton organization IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in muscle cell development IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in Z disc IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in cell junction IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in cell projection IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in cortical actin cytoskeleton IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
alpha-actinin-4

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Nannospalax galili Annotation Release 102 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference S.galili_v1.0 Primary Assembly

Genomic

  1. NW_008355971.1 Reference S.galili_v1.0 Primary Assembly

    Range
    1655473..1724995
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_008853924.3 → XP_008852146.1  alpha-actinin-4 isoform X5

    Conserved Domains (5) summary
    COG5069
    Location:48 → 311
    SAC6; Ca2+-binding actin-bundling protein fimbrin/plastin (EF-Hand superfamily) [Cytoskeleton]
    COG5126
    Location:762 → 893
    FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]
    cd00176
    Location:414 → 640
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    pfam08726
    Location:863 → 929
    EFhand_Ca_insen; Ca2+ insensitive EF hand
    pfam00435
    Location:293 → 402
    Spectrin; Spectrin repeat

  2. XM_008853920.2 → XP_008852142.1  alpha-actinin-4 isoform X1

    UniProtKB/TrEMBL
    A0A8C6WD03
    Related
    ENSNGAP00000025133.1, ENSNGAT00000030852.1
    Conserved Domains (5) summary
    PTZ00184
    Location:759 → 868
    PTZ00184; calmodulin; Provisional
    COG5069
    Location:48 → 311
    SAC6; Ca2+-binding actin-bundling protein fimbrin/plastin (EF-Hand superfamily) [Cytoskeleton]
    cd00176
    Location:414 → 640
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    pfam08726
    Location:841 → 907
    EFhand_Ca_insen; Ca2+ insensitive EF hand
    pfam00435
    Location:293 → 402
    Spectrin; Spectrin repeat

  3. XM_008853923.2 → XP_008852145.1  alpha-actinin-4 isoform X3

    Conserved Domains (5) summary
    COG5069
    Location:48 → 311
    SAC6; Ca2+-binding actin-bundling protein fimbrin/plastin (EF-Hand superfamily) [Cytoskeleton]
    COG5126
    Location:762 → 866
    FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]
    cd00176
    Location:414 → 640
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    pfam08726
    Location:836 → 902
    EFhand_Ca_insen; Ca2+ insensitive EF hand
    pfam00435
    Location:293 → 402
    Spectrin; Spectrin repeat

  4. XM_008853921.3 → XP_008852143.1  alpha-actinin-4 isoform X2

    Conserved Domains (5) summary
    PTZ00184
    Location:759 → 868
    PTZ00184; calmodulin; Provisional
    COG5069
    Location:48 → 311
    SAC6; Ca2+-binding actin-bundling protein fimbrin/plastin (EF-Hand superfamily) [Cytoskeleton]
    cd00176
    Location:414 → 640
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    pfam08726
    Location:841 → 907
    EFhand_Ca_insen; Ca2+ insensitive EF hand
    pfam00435
    Location:293 → 402
    Spectrin; Spectrin repeat

  5. XM_008853922.2 → XP_008852144.1  alpha-actinin-4 isoform X4

    Conserved Domains (5) summary
    COG5069
    Location:48 → 311
    SAC6; Ca2+-binding actin-bundling protein fimbrin/plastin (EF-Hand superfamily) [Cytoskeleton]
    COG5126
    Location:762 → 866
    FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]
    cd00176
    Location:414 → 640
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    pfam08726
    Location:836 → 902
    EFhand_Ca_insen; Ca2+ insensitive EF hand
    pfam00435
    Location:293 → 402
    Spectrin; Spectrin repeat
Nucleotide Protein
Heading Accession and Version

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