PEG10 paternally expressed 10 [Callithrix jacchus (white-tufted-ear marmoset)] - Gene

Summary

Gene symbol: PEG10
Gene description: paternally expressed 10
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Callithrix jacchus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Platyrrhini; Cebidae; Callitrichinae; Callithrix; Callithrix
Summary: This gene is thought to have been derived from the Ty3/Gypsy family of retrotransposons. It contains two overlapping open reading frames, RF1 and RF2, and expresses two proteins: a shorter, gag-like protein (with a CCHC-type zinc finger domain) from RF1; and a longer, gag/pol-like fusion protein (with an additional aspartic protease motif) from RF1/RF2 by -1 translational frameshifting (-1 FS). While -1 FS has been observed in RNA viruses and transposons in both prokaryotes and eukaryotes, this gene represents the first example of -1 FS in a eukaryotic cellular gene. This gene is highly conserved across mammalian species and retains the heptanucleotide (GGGAAAC) and pseudoknot elements required for -1 FS. It is expressed in adult and embryonic tissues (most notably in placenta) and reported to have a role in cell proliferation, differentiation, apoptosis and cancer development. Knockout mice lacking this gene showed early embryonic lethality with placental defects, indicating the importance of this gene in embryonic development. [provided by RefSeq, Oct 2014]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 8

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2023_03	current	mCalJa1.2.pat.X (GCF_011100555.1)	8	NC_071449.1 (52172678..52185646, complement)
105	previous assembly	Callithrix_jacchus_cj1700_1.1 (GCF_009663435.1)	8	NC_048390.1 (52998587..53011557, complement)

Chromosome 8 - NC_071449.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables nucleic acid binding	IEA Inferred from Electronic Annotation more info	PubMed
enables zinc ion binding	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in cytosol	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: retrotransposon-derived protein PEG10

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001302557.1 → NP_001289486.1 retrotransposon-derived protein PEG10 isoform 1

Status: REVIEWED

Description

Transcript Variant: This variant (1) has two overlapping open reading frames (RFI and RF2). This longer isoform (1) is derived from RF1/RF2 by -1 translational frameshifting.

Source sequence(s)

GAMP01017872, GAMR01018233

UniProtKB/TrEMBL

F7IMX4

Conserved Domains (4) summary

cd00303
Location:441 → 525

retropepsin_like; Retropepsins; pepsin-like aspartate proteases

pfam03732
Location:195 → 288

Retrotrans_gag; Retrotransposon gag protein

pfam15035
Location:79 → 125

Rootletin; Ciliary rootlet component, centrosome cohesion

pfam16297
Location:154 → 234

DUF4939; Domain of unknown function (DUF4939)
NM_001302558.1 → NP_001289487.1 retrotransposon-derived protein PEG10 isoform 2

Status: REVIEWED

Description

Transcript Variant: This variant (1) has two overlapping open reading frames (RFI and RF2). This isoform (2) produced from RF1 in the absence of -1 translational frameshifting has a shorter C-terminus compared to isoform 1.

Source sequence(s)

GAMP01017872, GAMR01018233

UniProtKB/TrEMBL

A0A8I3X484

Conserved Domains (3) summary

pfam03732
Location:195 → 288

Retrotrans_gag; Retrotransposon gag protein

pfam15035
Location:79 → 125

Rootletin; Ciliary rootlet component, centrosome cohesion

pfam16297
Location:154 → 234

DUF4939; Domain of unknown function (DUF4939)