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Maml1 mastermind like transcriptional coactivator 1 [ Mus musculus (house mouse) ]

Gene ID: 103806, updated on 23-Jun-2021

Summary

Official Symbol
Maml1provided by MGI
Official Full Name
mastermind like transcriptional coactivator 1provided by MGI
Primary source
MGI:MGI:1890504
See related
Ensembl:ENSMUSG00000050567
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Mam-; Mam1; Mam-1; AI644666; AW743257; mKIAA0200; D930008C07Rik
Expression
Ubiquitous expression in ovary adult (RPKM 11.2), thymus adult (RPKM 11.1) and 28 other tissues See more
Orthologs
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Genomic context

See Maml1 in Genome Data Viewer
Location:
11; 11 B1.3
Exon count:
6
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (50146458..50183955, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (50255634..50293131, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 11 NC_000077.5 (50069136..50105838, complement)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene mannoside acetylglucosaminyltransferase 4, isoenzyme B Neighboring gene microRNA 6919 Neighboring gene leukotriene C4 synthase Neighboring gene calnexin Neighboring gene predicted gene, 46280 Neighboring gene predicted gene, 31865

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables peptide antigen binding ISO
Inferred from Sequence Orthology
more info
 
enables protein kinase binding ISO
Inferred from Sequence Orthology
more info
 
enables transcription coactivator activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables transcription coactivator activity IDA
Inferred from Direct Assay
more info
PubMed 
enables transcription coactivator activity ISO
Inferred from Sequence Orthology
more info
PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within Notch signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in Notch signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in Notch signaling pathway TAS
Traceable Author Statement
more info
PubMed 
involved_in atrioventricular node cell development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within myoblast differentiation IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in positive regulation of muscle cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of myotube differentiation IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of myotube differentiation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
PubMed 
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of transcription of Notch receptor target IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within positive regulation of transcription of Notch receptor target IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
part_of MAML1-RBP-Jkappa- ICN1 complex ISO
Inferred from Sequence Orthology
more info
 
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
 
located_in nuclear speck IEA
Inferred from Electronic Annotation
more info
 
is_active_in nucleoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
PubMed 

General protein information

Preferred Names
mastermind-like protein 1
Names
mastermind like 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_175334.3NP_780543.2  mastermind-like protein 1

    See identical proteins and their annotated locations for NP_780543.2

    Status: VALIDATED

    Source sequence(s)
    AI509152, AK129088, BC058658, BC094599
    Consensus CDS
    CCDS24632.2
    UniProtKB/Swiss-Prot
    Q6T264
    Related
    ENSMUSP00000059210.5, ENSMUST00000059458.5
    Conserved Domains (2) summary
    pfam03153
    Location:278444
    TFIIA; Transcription factor IIA, alpha/beta subunit
    pfam09596
    Location:1471
    MamL-1; MamL-1 domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    50146458..50183955 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006531918.5XP_006531981.1  mastermind-like protein 1 isoform X1

    Conserved Domains (2) summary
    pfam09596
    Location:1471
    MamL-1; MamL-1 domain
    pfam09770
    Location:411606
    PAT1; Topoisomerase II-associated protein PAT1
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