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Nt5m 5',3'-nucleotidase, mitochondrial [ Mus musculus (house mouse) ]

Gene ID: 103850, updated on 5-Mar-2024

Summary

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Official Symbol
Nt5mprovided by MGI
Official Full Name
5',3'-nucleotidase, mitochondrialprovided by MGI
Primary source
MGI:MGI:1917127
See related
Ensembl:ENSMUSG00000032615 AllianceGenome:MGI:1917127
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
dNT-2; 2010013E09Rik
Summary
Enables 5'-nucleotidase activity. Acts upstream of or within dUMP catabolic process. Located in mitochondrion. Is expressed in several structures, including ear; genitourinary system; integumental system; nervous system; and respiratory system. Orthologous to human NT5M (5',3'-nucleotidase, mitochondrial). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in testis adult (RPKM 20.3), adrenal adult (RPKM 18.6) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
11 B1.3; 11 37.8 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (59730233..59767359)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (59847947..59876533)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene folliculin Neighboring gene STARR-seq mESC enhancer starr_29631 Neighboring gene predicted gene 16062 Neighboring gene COP9 signalosome subunit 3 Neighboring gene predicted gene, 51946 Neighboring gene STARR-positive B cell enhancer ABC_E5233 Neighboring gene STARR-positive B cell enhancer ABC_E2354 Neighboring gene STARR-seq mESC enhancer starr_29632 Neighboring gene STARR-positive B cell enhancer ABC_E6991 Neighboring gene RIKEN cDNA 1810063I02 gene Neighboring gene predicted gene, 51900

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Mouse cytosolic and mitochondrial deoxyribonucleotidases: cDNA cloning of the mitochondrial enzyme, gene structures, chromosomal mapping and comparison with the human orthologs. Rampazzo C, et al. Gene, 2002 Jul 10. PMID 12234672
  2. Penetrance of craniofacial anomalies in mouse models of Smith-Magenis syndrome is modified by genomic sequence surrounding Rai1: not all null alleles are alike. Yan J, et al. Am J Hum Genet, 2007 Mar. PMID 17273973, Free PMC Article
  3. Integrated analysis of protein composition, tissue diversity, and gene regulation in mouse mitochondria. Mootha VK, et al. Cell, 2003 Nov 26. PMID 14651853
  4. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article
  5. GenePaint.org: an atlas of gene expression patterns in the mouse embryo. Visel A, et al. Nucleic Acids Res, 2004 Jan 1. PMID 14681479, Free PMC Article

See all (22) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables 5'-nucleotidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables 5'-nucleotidase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within dUMP catabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in deoxyribonucleotide catabolic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within nucleotide metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in pyrimidine deoxyribonucleotide catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in mitochondrion HDA PubMed 
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
 PubMed 

General protein information

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Preferred Names
5'(3')-deoxyribonucleotidase, mitochondrial
Names
deoxy-5'-nucleotidase 2
NP_001405279.1
NP_001405281.1
NP_001405282.1
NP_001405283.1
NP_001405284.1
NP_598790.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001418350.1 → NP_001405279.1  5'(3')-deoxyribonucleotidase, mitochondrial isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC068808
    Related
    ENSMUST00000149076.8

  2. NM_001418352.1 → NP_001405281.1  5'(3')-deoxyribonucleotidase, mitochondrial isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC068808

  3. NM_001418353.1 → NP_001405282.1  5'(3')-deoxyribonucleotidase, mitochondrial isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC068808

  4. NM_001418354.1 → NP_001405283.1  5'(3')-deoxyribonucleotidase, mitochondrial isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC068808

  5. NM_001418355.1 → NP_001405284.1  5'(3')-deoxyribonucleotidase, mitochondrial isoform 6

    Status: VALIDATED

    Source sequence(s)
    AC068808

  6. NM_134029.3 → NP_598790.1  5'(3')-deoxyribonucleotidase, mitochondrial isoform 1 precursor

    See identical proteins and their annotated locations for NP_598790.1

    Status: VALIDATED

    Source sequence(s)
    AC068808
    Consensus CDS
    CCDS24779.1
    UniProtKB/Swiss-Prot
    Q8VCE6
    Related
    ENSMUSP00000099756.4, ENSMUST00000102695.4
    Conserved Domains (2) summary
    pfam00702
    Location:30 → 160
    Hydrolase; haloacid dehalogenase-like hydrolase
    cl21460
    Location:30 → 219
    HAD_like; Haloacid Dehalogenase-like Hydrolases

RNA

  1. NR_184728.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC068808

  2. NR_184729.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC068808

  3. NR_184730.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC068808

  4. NR_184731.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC068808

  5. NR_184732.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC068808

  6. NR_184733.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC068808

  7. NR_184734.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC068808

  8. NR_184735.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC068808

  9. NR_184736.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC068808

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    59730233..59767359
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8VCE6.1 GenPept UniProtKB/Swiss-Prot:Q8VCE6

Gene LinkOut

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