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Cyp27a1 cytochrome P450, family 27, subfamily a, polypeptide 1 [ Mus musculus (house mouse) ]

Gene ID: 104086, updated on 25-Jan-2022

Summary

Official Symbol
Cyp27a1provided by MGI
Official Full Name
cytochrome P450, family 27, subfamily a, polypeptide 1provided by MGI
Primary source
MGI:MGI:88594
See related
Ensembl:ENSMUSG00000026170 AllianceGenome:MGI:88594
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Cyp27; 1300013A03Rik
Summary
Predicted to enable Hsp70 protein binding activity; heme binding activity; and monooxygenase activity. Predicted to be involved in bile acid biosynthetic process; calcitriol biosynthetic process from calciol; and cholesterol catabolic process. Predicted to act upstream of or within steroid biosynthetic process. Located in mitochondrial inner membrane. Is expressed in several structures, including central nervous system; liver; male reproductive gland or organ; metanephros; and retina. Human ortholog(s) of this gene implicated in cerebrotendinous xanthomatosis. Orthologous to human CYP27A1 (cytochrome P450 family 27 subfamily A member 1). [provided by Alliance of Genome Resources, Nov 2021]
Expression
Biased expression in liver adult (RPKM 72.0), bladder adult (RPKM 14.6) and 14 other tissues See more
Orthologs
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Genomic context

See Cyp27a1 in Genome Data Viewer
Location:
1 C4; 1 38.54 cM
Exon count:
10
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (74752311..74777056)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (74713148..74737897)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 1 NC_000067.5 (74760148..74784464)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene serine/threonine kinase 36 Neighboring gene tubulin tyrosine ligase-like family, member 4 Neighboring gene protein kinase, AMP-activated, gamma 3 non-catalytic subunit Neighboring gene wingless-type MMTV integration site family, member 6 Neighboring gene predicted gene 29539

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables 3-alpha,7-alpha,12-alpha-trihydroxycholestan-26-al 26-oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
 
enables Hsp70 protein binding ISO
Inferred from Sequence Orthology
more info
 
enables cholestanetriol 26-monooxygenase activity ISO
Inferred from Sequence Orthology
more info
 
enables cholesterol 26-hydroxylase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables cholesterol 26-hydroxylase activity ISO
Inferred from Sequence Orthology
more info
 
enables heme binding ISO
Inferred from Sequence Orthology
more info
 
enables iron ion binding IEA
Inferred from Electronic Annotation
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables monooxygenase activity IEA
Inferred from Electronic Annotation
more info
 
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
 
enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen IEA
Inferred from Electronic Annotation
more info
 
enables vitamin D3 25-hydroxylase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables vitamin D3 25-hydroxylase activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in bile acid biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
involved_in calcitriol biosynthetic process from calciol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in calcitriol biosynthetic process from calciol ISO
Inferred from Sequence Orthology
more info
 
involved_in cholesterol catabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in cholesterol metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in cholesterol metabolic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within lipid metabolic process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within steroid biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within steroid metabolic process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in mitochondrial envelope ISO
Inferred from Sequence Orthology
more info
 
located_in mitochondrial inner membrane HDA PubMed 
located_in mitochondrial inner membrane ISO
Inferred from Sequence Orthology
more info
 
located_in mitochondrion HDA PubMed 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
sterol 26-hydroxylase, mitochondrial
Names
5-beta-cholestane-3-alpha,7-alpha,12-alpha-triol 26-hydroxylase
5-beta-cholestane-3-alpha,7-alpha,12-alpha-triol 27-hydroxylase
cholesterol 27 hydroxylase
cytochrome P-450C27/25
cytochrome P450, 27a1
sterol 27-hydroxylase
vitamin D(3) 25-hydroxylase
NP_077226.2
XP_006495670.1
XP_036021544.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_024264.5NP_077226.2  sterol 26-hydroxylase, mitochondrial precursor

    See identical proteins and their annotated locations for NP_077226.2

    Status: VALIDATED

    Source sequence(s)
    AC152409, AK004977, CV560359
    Consensus CDS
    CCDS15054.1
    UniProtKB/Swiss-Prot
    Q9DBG1
    Related
    ENSMUSP00000027356.6, ENSMUST00000027356.7
    Conserved Domains (1) summary
    pfam00067
    Location:82527
    p450; Cytochrome P450

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    74752311..74777056
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006495607.4XP_006495670.1  sterol 26-hydroxylase, mitochondrial isoform X2

    Conserved Domains (1) summary
    pfam00067
    Location:11385
    p450; Cytochrome P450
  2. XM_036165651.1XP_036021544.1  sterol 26-hydroxylase, mitochondrial isoform X1

    Conserved Domains (1) summary
    cl41757
    Location:1431
    cytochrome_P450; cytochrome P450 (CYP) superfamily
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