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Itga9 integrin alpha 9 [ Mus musculus (house mouse) ]

Gene ID: 104099, updated on 21-Apr-2024

Summary

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Official Symbol
Itga9provided by MGI
Official Full Name
integrin alpha 9provided by MGI
Primary source
MGI:MGI:104756
See related
Ensembl:ENSMUSG00000039115 AllianceGenome:MGI:104756
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
(alpha)9; D130073C02; D9Ertd428e; 2610002H11Rik; 6720458D17Rik
Summary
Predicted to enable metal ion binding activity. Acts upstream of or within neutrophil chemotaxis. Located in basal plasma membrane. Is expressed in several structures, including alimentary system; brain; genitourinary system; skin; and vascular system. Used to study congenital chylothorax. Human ortholog(s) of this gene implicated in cerebral infarction; hypertension; and pancreatic cancer. Orthologous to human ITGA9 (integrin subunit alpha 9). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in adrenal adult (RPKM 10.7), ovary adult (RPKM 10.3) and 22 other tissues See more
Orthologs
human all
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Genomic context

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Location:
9 F3; 9 70.32 cM
Exon count:
29
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (118435777..118730071)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (118606709..118901003)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 33460 Neighboring gene STARR-seq mESC enhancer starr_25460 Neighboring gene golgin A4 Neighboring gene family with sequence similarity 64, member A pseudogene Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:118586586-118586773 Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:118623570-118623818 Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:118625206-118625362 Neighboring gene STARR-seq mESC enhancer starr_25461 Neighboring gene STARR-positive B cell enhancer mm9_chr9:118780330-118780630 Neighboring gene predicted gene 10157 Neighboring gene predicted gene, 39454 Neighboring gene uncharacterized LOC102636563 Neighboring gene predicted gene, 51695 Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:118834312-118834499 Neighboring gene CTD small phosphatase like Neighboring gene VISTA enhancer mm1627 Neighboring gene STARR-seq mESC enhancer starr_25464 Neighboring gene predicted gene, 53514

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Integrin α9 regulates smooth muscle cell phenotype switching and vascular remodeling. Jain M, et al. JCI Insight, 2021 May 24. PMID 34027892, Free PMC Article
  2. Integrin α9 on lymphatic endothelial cells regulates lymphocyte egress. Ito K, et al. Proc Natl Acad Sci U S A, 2014 Feb 25. PMID 24516133, Free PMC Article
  3. Blockade of interaction of alpha9 integrin with its ligands hinders the formation of granulation in cutaneous wound healing. Nakayama Y, et al. Lab Invest, 2010 Jun. PMID 20308983
  4. The Integrin alpha9beta1 contributes to granulopoiesis by enhancing granulocyte colony-stimulating factor receptor signaling. Chen C, et al. Immunity, 2006 Dec. PMID 17137800
  5. Fatal bilateral chylothorax in mice lacking the integrin alpha9beta1. Huang XZ, et al. Mol Cell Biol, 2000 Jul. PMID 10866676, Free PMC Article

See all (96) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Depletion of CUL4B in macrophages ameliorates diabetic kidney disease via miR-194-5p/ITGA9 axis.
    Title: Depletion of CUL4B in macrophages ameliorates diabetic kidney disease via miR-194-5p/ITGA9 axis.
  2. study provides in vitro and in vivo evidence that the interaction between XCL1 and alpha9 integrin has an important role for autoimmune diseases
    Title: A Novel α9 Integrin Ligand, XCL1/Lymphotactin, Is Involved in the Development of Murine Models of Autoimmune Diseases.
  3. A novel motif, LRSKSRSFQVSDEQY, in the C-terminal fragment of MMP-3/7-cleaved mouse OPN binds to alpha9beta1 integrin.
    Title: A novel cryptic binding motif, LRSKSRSFQVSDEQY, in the C-terminal fragment of MMP-3/7-cleaved osteopontin as a novel ligand for α9β1 integrin is involved in the anti-type II collagen antibody-induced arthritis.
  4. Notch signaling is required for proper lymphatic valve formation and regulates integrin alpha9 and fibronectin EIIIA expression during valve morphogenesis
    Title: Notch signaling functions in lymphatic valve formation.
  5. alpha9beta1 integrin acts as a critical intrinsic regulator of human rheumatoid arthritis.
    Title: α9β1 integrin acts as a critical intrinsic regulator of human rheumatoid arthritis.
  6. Integrin alpha9 on lymphatic endothelial cells regulates lymphocyte egress.
    Title: Integrin α9 on lymphatic endothelial cells regulates lymphocyte egress.
  7. EMILIN1/integrin alpha 9 beta 1 interaction contributes to lymphatic valve formation, maintenance, and function.
    Title: EMILIN1/α9β1 integrin interaction is crucial in lymphatic valve formation and maintenance.
  8. alpha(4) and alpha(9) integrins interacting with OPN via the SLAYGLR domain play a key role in macrophage biology by regulating migration, survival, and accumulation.
    Title: Osteopontin mediates macrophage chemotaxis via α4 and α9 integrins and survival via the α4 integrin.
  9. integrin alpha9beta1 appears to serve as a brake on airway smooth muscle contraction by recruiting SSAT, which facilitates local catabolism of polyamines and thereby inhibits PIP5K1gamma.
    Title: Integrin α9β1 in airway smooth muscle suppresses exaggerated airway narrowing.
  10. EMILIN1 is identified as a novel ligand for keratinocyte alpha9beta1 integrin, suggesting prospective roles for this receptor-ligand pair in skin homeostasis.
    Title: EMILIN1-α4/α9 integrin interaction inhibits dermal fibroblast and keratinocyte proliferation.
Submit: New GeneRIF Correction See all GeneRIFs (19)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables collagen binding ISO
Inferred from Sequence Orthology
more info
  
enables integrin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables integrin binding involved in cell-matrix adhesion IDA
Inferred from Direct Assay
more info
 PubMed 
enables laminin binding ISO
Inferred from Sequence Orthology
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within cell adhesion ISO
Inferred from Sequence Orthology
more info
  
involved_in cell adhesion mediated by integrin IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cell-cell adhesion IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cell-matrix adhesion IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in integrin-mediated signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of vasoconstriction ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within neutrophil chemotaxis IGI
Inferred from Genetic Interaction
more info
 PubMed 
Component Evidence Code Pubs
located_in basal plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in external side of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of integrin alpha9-beta1 complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of integrin alpha9-beta1 complex ISO
Inferred from Sequence Orthology
more info
  
part_of integrin complex IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
integrin alpha-9

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001113514.1 → NP_001106986.1  integrin alpha-9 isoform b

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and coding region compared to variant 1. The resulting isoform (b) is shorter at the N-terminus compared to isoform a.
    Source sequence(s)
    AC156800, AK139690, CF913701
    Consensus CDS
    CCDS52961.1
    UniProtKB/TrEMBL
    E9QAP0, Q8BJG9
    Related
    ENSMUSP00000122417.2, ENSMUST00000124360.8
    Conserved Domains (1) summary
    pfam08441
    Location:2 → 318
    Integrin_alpha2; Integrin alpha

  2. NM_133721.2 → NP_598482.2  integrin alpha-9 isoform a precursor

    See identical proteins and their annotated locations for NP_598482.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a).
    Source sequence(s)
    AC156800, AK153585, BB638856, CN698186
    Consensus CDS
    CCDS23604.1
    UniProtKB/Swiss-Prot
    B8JK39, B9EKC4
    UniProtKB/TrEMBL
    Q91YD5
    Related
    ENSMUSP00000044227.8, ENSMUST00000044165.14
    Conserved Domains (2) summary
    smart00191
    Location:362 → 415
    Int_alpha; Integrin alpha (beta-propellor repeats)
    pfam08441
    Location:460 → 904
    Integrin_alpha2; Integrin alpha

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    118435777..118730071
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
B8JK39.1 GenPept UniProtKB/Swiss-Prot:B8JK39

Gene LinkOut

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