Format

Send to:

Choose Destination

Acly ATP citrate lyase [ Mus musculus (house mouse) ]

Gene ID: 104112, updated on 5-Jan-2022

Summary

Official Symbol
Aclyprovided by MGI
Official Full Name
ATP citrate lyaseprovided by MGI
Primary source
MGI:MGI:103251
See related
Ensembl:ENSMUSG00000020917
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
AW538652; A730098H14Rik
Summary
Enables ATP citrate synthase activity. Predicted to be involved in acetyl-CoA biosynthetic process and carboxylic acid metabolic process. Predicted to act upstream of or within lipid metabolic process. Located in mitochondrion. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Orthologous to human ACLY (ATP citrate lyase). [provided by Alliance of Genome Resources, Nov 2021]
Expression
Broad expression in subcutaneous fat pad adult (RPKM 333.0), mammary gland adult (RPKM 298.7) and 24 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See Acly in Genome Data Viewer
Location:
11; 11 D
Exon count:
30
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (100367178..100418826, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (100476352..100528000, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 11 NC_000077.5 (100337670..100389215, complement)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene 5'-nucleotidase, cytosolic IIIB Neighboring gene kelch-like 10 Neighboring gene kelch-like 11 Neighboring gene microRNA 7116 Neighboring gene nuclear encoded tRNA serine 1 (anticodon GGA) Neighboring gene outer dynein arm complex subunit 4

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables ATP citrate synthase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables ATP citrate synthase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables ATP citrate synthase activity ISO
Inferred from Sequence Orthology
more info
 
enables acyltransferase, acyl groups converted into alkyl on transfer IEA
Inferred from Electronic Annotation
more info
 
enables catalytic activity IEA
Inferred from Electronic Annotation
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in acetyl-CoA biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in acetyl-CoA biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
involved_in acetyl-CoA metabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in citrate metabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in fatty acid biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in fatty acid biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
involved_in lipid biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within lipid metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in oxaloacetate metabolic process ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in mitochondrion HDA PubMed 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
ATP-citrate synthase
Names
ATP-citrate (pro-S-)-lyase
citrate cleavage enzyme
NP_001186225.1
NP_598798.1
XP_036012093.1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001199296.1NP_001186225.1  ATP-citrate synthase isoform 1

    See identical proteins and their annotated locations for NP_001186225.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and it encodes the longer protein (isoform 1).
    Source sequence(s)
    AK132755, BE623317, BX842667
    Consensus CDS
    CCDS56807.1
    UniProtKB/TrEMBL
    Q3V117
    Related
    ENSMUSP00000103012.2, ENSMUST00000107389.8
    Conserved Domains (2) summary
    cl25712
    Location:1419
    SucC; Succinyl-CoA synthetase, beta subunit [Energy production and conversion]
    cl26126
    Location:4891094
    Ligase_CoA; CoA-ligase
  2. NM_134037.3NP_598798.1  ATP-citrate synthase isoform 2

    See identical proteins and their annotated locations for NP_598798.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate, in-frame, exon in the middle of the coding region, compared to variant 1. The resulting protein (isoform 2) is shorter when it is compared to isoform 1.
    Source sequence(s)
    BC056378, BE623317, BX842667
    Consensus CDS
    CCDS25425.1
    UniProtKB/Swiss-Prot
    Q91V92
    Related
    ENSMUSP00000007131.10, ENSMUST00000007131.16
    Conserved Domains (2) summary
    cl25712
    Location:1419
    SucC; Succinyl-CoA synthetase, beta subunit [Energy production and conversion]
    cl26126
    Location:4791084
    Ligase_CoA; CoA-ligase

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    100367178..100418826 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036156200.1XP_036012093.1  ATP-citrate synthase isoform X1

    Conserved Domains (1) summary
    PLN02522
    Location:1591
    PLN02522; ATP citrate (pro-S)-lyase
Support Center