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Gldc glycine decarboxylase [ Mus musculus (house mouse) ]

Gene ID: 104174, updated on 6-May-2021

Summary

Official Symbol
Gldcprovided by MGI
Official Full Name
glycine decarboxylaseprovided by MGI
Primary source
MGI:MGI:1341155
See related
Ensembl:ENSMUSG00000024827
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
D19Wsu57; b2b2679C; D19Wsu57e; b2b2679Clo; D030049L12Rik
Expression
Broad expression in liver adult (RPKM 46.0), kidney adult (RPKM 27.4) and 15 other tissues See more
Orthologs
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Genomic context

See Gldc in Genome Data Viewer
Location:
19 C1; 19 24.87 cM
Exon count:
25
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (30075841..30152841, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (30098441..30175441, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 19 NC_000085.5 (30172937..30249908, complement)

Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene tumor protein D52-like 3 Neighboring gene ubiquitin-like, containing PHD and RING finger domains 2 Neighboring gene ribosomal protein L31, pseudogene 20 Neighboring gene mannose-binding lectin (protein C) 2 Neighboring gene protein dpy-30 homolog

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Targeted (1) 
  • Chemically induced (ENU) (1) 
  • Endonuclease-mediated (1) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables catalytic activity IEA
Inferred from Electronic Annotation
more info
 
enables enzyme binding ISO
Inferred from Sequence Orthology
more info
 
enables glycine binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables glycine binding ISO
Inferred from Sequence Orthology
more info
 
enables glycine dehydrogenase (decarboxylating) activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables glycine dehydrogenase (decarboxylating) activity ISO
Inferred from Sequence Orthology
more info
PubMed 
enables lyase activity IEA
Inferred from Electronic Annotation
more info
 
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
 
enables pyridoxal phosphate binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables pyridoxal phosphate binding ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
part_of glycine cleavage complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of glycine cleavage complex ISO
Inferred from Sequence Orthology
more info
 
located_in mitochondrion HDA PubMed 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
glycine dehydrogenase (decarboxylating), mitochondrial
Names
glycine cleavage system P protein
glycine dehydrogenase (aminomethyl-transferring)
glycine dehydrogenase [decarboxylating], mitochondrial
NP_613061.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_138595.2NP_613061.1  glycine dehydrogenase (decarboxylating), mitochondrial precursor

    See identical proteins and their annotated locations for NP_613061.1

    Status: VALIDATED

    Source sequence(s)
    AC157986, BC017135, BF020198
    Consensus CDS
    CCDS37956.1
    UniProtKB/Swiss-Prot
    Q91W43
    Related
    ENSMUSP00000025778.8, ENSMUST00000025778.9
    Conserved Domains (3) summary
    COG1003
    Location:509982
    GcvP2; Glycine cleavage system protein P (pyridoxal-binding), C-terminal domain [Amino acid transport and metabolism]
    PRK05367
    Location:621014
    PRK05367; glycine dehydrogenase; Provisional
    pfam02347
    Location:70493
    GDC-P; Glycine cleavage system P-protein

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000085.7 Reference GRCm39 C57BL/6J

    Range
    30075841..30152841 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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